盐酸克林沙星
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- CAS号:
- 105956-99-8
- 英文名:
- Clinafloxacin hydrochloride
- 英文别名:
- M 1091;KR 11095;ClinafoxacinHCl;CLINAFLOXACIN HCL;Clinafloxacinhydrochloride;CLINANFLOXACIN HYDROCHLORIDE;HYDROGEN CLINAFLOXACIN CHLORIDE;Clinafloxacin hydrochloride USP/EP/BP;Clinafloxacin hydrochloride (PD127391);7-(3-aminopyrrolidin-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-4-oxoquinoline-3-carboxylic acid hydrochloride
- 中文名:
- 盐酸克林沙星
- 中文别名:
- 盐酸克林沙星;克林沙星盐酸盐;包被盐酸可林沙星;7-(3-氨基-1-吡咯烷基)-8-氯-1-环丙基-6-氟-1,4-二氢-4-氧代-3-喹啉羧酸盐酸盐
- CBNumber:
- CB3148235
- 分子式:
- C17H18Cl2FN3O3
- 分子量:
- 402.25
- MOL File:
- 105956-99-8.mol
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盐酸克林沙星化学性质
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熔点:
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162-168°C
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储存条件:
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Refrigerator
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溶解度:
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DMSO (Slightly), Methanol (Slightly), Water (Slightly, Heated)
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形态:
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Solid
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颜色:
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Pale Yellow to Light Yellow
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稳定性:
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Hygroscopic
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盐酸克林沙星性质、用途与生产工艺
Clinafloxacin hydrochloride (AM 1091 hydrochloride) 是一种高效广谱氟喹诺酮类抗生素 (antibiotic),对革兰氏阳性、革兰氏阴性和厌氧病原体均有抑制活性。Clinafloxacin hydrochloride 对金黄色葡萄球菌的DNA促旋酶 (DNA gyrase) 和拓扑异构酶 IV (topoisomerase IV) 有抑制作用,IC50 值分别为 0.92 µg/ml 和 1.62 µg/ml。
MIC: 1 μg/ml (parC-gyrA mutants,
S. pneumonia
)
Clinafloxacin exhibits activity against
S. pneumonia
with an
MIC
of 1μg/ml for the parC-gyrA mutants.Clinafloxacin hydrochloride has antibacterial activities against target-altered mutant strains of
S. aureus
. It against Wild type
S. aureus
,
gyr
A mutant
S. aureus
and
gyr
A mutant
S. aureus
with MIC values of 0.016 µg/ml, 0.063 µg/ml and 0.915 µg/ml, respectively.
Clinafloxacin is very effective for the therapy of penicillin-resistant, ciprofloxacin-susceptible pneumococcal meningitis in the rabbit model.
With the CS strain (2349)(Clinafloxacin MIC=0.12 μg/ml), at a dose of 10 mg/kg and 20 mg/kg per day Clinafloxacin achieves an initial reduction at 6 hr. Both are bactericidal at this point but presents regrowth at 24 hr, and the final reduction at 24 hr in mean log cfu/ml is 22.30 and 23.83, respectively. However, With the CR strain (4371)(Clinafloxacin MIC=0.5 μg/ml), Clinafloxacin even at 20 mg/kg per day does not decrease bacterial titers at any time point in this rabbit model of meningitis.
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105956-99-8, 盐酸克林沙星 相关搜索:
- API
- Pharmaceuticals
- Intermediates & Fine Chemicals
- Heterocycles
- Aromatics
- Amines
- 生化试剂
- 医用原料
- 医用原料
- C17H17ClFN3O3HCl
- 克林沙星盐酸盐
- 包被盐酸可林沙星
- 盐酸克林沙星
- 7-(3-氨基-1-吡咯烷基)-8-氯-1-环丙基-6-氟-1,4-二氢-4-氧代-3-喹啉羧酸盐酸盐
- 105956-99-8
- 7-(3-amino-1-pyrrolidinyl)-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-Quinolinecarboxylic acid hydrochloride (1:1)
- 3-Quinolinecarboxylic acid, 7-(3-amino-1-pyrrolidinyl)-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-, hydrochloride (1:1)
- 7-(3-aminopyrrolidin-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid hydrochloride
- ClinafoxacinHCl
- HYDROGEN CLINAFLOXACIN CHLORIDE
- Clinafloxacin hydrochloride USP/EP/BP
- Clinafloxacin hydrochloride (PD127391)
- M 1091
- KR 11095
- 3-Quinolinecarboxylic acid, 7-(3-aMino-1-pyrrolidinyl)-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-, Monohydrochloride (9CI)
- 7-(3-azanylpyrrolidin-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-4-oxo-quinoline-3-carboxylic acid hydrochloride
- 7-(3-aminopyrrolidin-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-4-oxoquinoline-3-carboxylic acid hydrochloride
- 7-(3-aminopyrrolidin-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-4-keto-quinoline-3-carboxylic acid hydrochloride
- 7-(3-Amino-1-pyrrolidinyl)-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid hydrochloride
- Clinafloxacinhydrochloride
- CLINANFLOXACIN HYDROCHLORIDE
- CLINAFLOXACIN HCL