阿佐昔芬盐酸盐
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- CAS号:
- 182133-27-3
- 英文名:
- ARZOXIFENE HCL
- 英文别名:
- Serm 3;Ly 353381;Ly 353381 HCl;ARZOXIFENE HCL;Arzoxifene hydrochloride;NHSNLUIMAQQXGR-UHFFFAOYSA-N;Arzoxifene (hydrochloride salt);2-(p-Methoxyphenyl)-3-(p-(2-(1-piperidinyl)ethoxy)phenoxy)benzo(B)thiophene-6-ol hydrochloride;2-(4-Methoxyphenyl)-3-(4-(2-(1-piperidinyl)ethoxy)phenoxy)benzo(B)thiophene-6-ol hydrochloride;Benzo(B)thiophene-6-ol, 2-(4-methoxyphenyl)-3-(4-(2-(1-piperidinyl)ethoxy)phenoxy)-, hydrochloride
- 中文名:
- 阿佐昔芬盐酸盐
- 中文别名:
- 阿佐昔芬盐酸盐;化合物 T10379
- CBNumber:
- CB31515928
- 分子式:
- C28H29NO4S.ClH
- 分子量:
- 512.067
- MOL File:
- 182133-27-3.mol
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阿佐昔芬盐酸盐性质、用途与生产工艺
Arzoxifene hydrocloride是一种选择性的雌激素受体 (estrogen receptor) 调节剂，它是乳腺和子宫组织中有效的雌激素拮抗剂，同时作为维持骨密度和降低血清胆固醇的雌激素激动剂。
Arzoxifene inhibits cell growth as effectively as the antiestrogen tamoxifen. Northern analysis reveals that arzoxifene exerts a statistically significant inhibition of pS2 and progesterone receptor B mRNA expression. Significant agonistic effect is observed on the antitrypsin mRNA expression. In contrast to estradiol and tamoxifen, arzoxifene does not upregulate cathepsin D mRNA and protein expression.
Arzoxifene prevents the ovariectomy-induced increase in body weight and serum cholesterol levels of treated rats and lowers them to below sham levels in a dose dependent manner, with maximum efficacy similar to estrogen or raloxifene. Arzoxifene (LY353381.HCl) prevents loss of bone due to ovariectomy with an ED
50
of about 0.01 mg/kg with maximal efficacy observed at 0.1-1 mg/kg/day. Arzoxifene (LY353381.HCl) antagonizes the estrogen-induced elevation in uterine weight down to vehicle-dosed control levels with ED
50
of 0.03 mg/kg/day.
阿佐昔芬盐酸盐
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| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/01/25 | HY-13556A | Arzoxifene hydrochloride | | 1 mg | 3600元 |
| 2024/01/25 | HY-13556A | 阿佐昔芬盐酸盐
Arzoxifene hydrochloride | 182133-27-3 | 5 mg | 9000元 |
182133-27-3, 阿佐昔芬盐酸盐 相关搜索:
- C28H29NO4SHCl
- 化合物 T10379
- 阿佐昔芬盐酸盐
- 182133-27-3
- Arzoxifene (hydrochloride salt)
- NHSNLUIMAQQXGR-UHFFFAOYSA-N
- Serm 3
- Ly 353381 HCl
- Ly 353381
- Benzo(B)thiophene-6-ol, 2-(4-methoxyphenyl)-3-(4-(2-(1-piperidinyl)ethoxy)phenoxy)-, hydrochloride
- Arzoxifene hydrochloride
- 2-(p-Methoxyphenyl)-3-(p-(2-(1-piperidinyl)ethoxy)phenoxy)benzo(B)thiophene-6-ol hydrochloride
- 2-(4-Methoxyphenyl)-3-(4-(2-(1-piperidinyl)ethoxy)phenoxy)benzo(B)thiophene-6-ol hydrochloride
- ARZOXIFENE HCL