依利曲坦中间体
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- CAS号:
- 143322-56-9
- 英文名:
- (R)-5-BROMO-3-[(1-METHYL-2-PYRROLIDINYL)METHYL]-1H-INDOLE
- 英文别名:
- InterMediate of Eletriptan;3-(N- benzyloxycarbonyl-D-prolyl)-5-bromoindole;(5R)3-(N-benzyloxycarbonyl-D-prolyl)-5-bromoindole;(R)-5-bromo-3-[(1-methyl-2-pyrrolidinyl)methyl]-1H-indole;(R)-Benzyl 2-(5-bromo-1H-indole-3-carbonyl)-pyrrolidine-1-carboxylate;(R)-(5-bromo-1H-indol-3-yl)[N-[(phenylmethoxy)carbonyl]-2-pyrrolidinyl]methanone;(R)-2-[(5-Bromo-1H-indol-3-yl)carbonyl]-1-pyrrolidinecarboxylic acid benzyl ester;(2R)-2-[(5-BroMo-1H-indol-3-yl)carbonyl]-1-pyrrolidinecarboxylic Acid PhenylMethyl Ester;1-Pyrrolidinecarboxylic acid, 2-[(5-bromo-1H-indol-3-yl)carbonyl]-, phenylmethyl ester, (R)-;1-Pyrrolidinecarboxylic acid, 2-[(5-bromo-1H-indol-3-yl)carbonyl]-, phenylmethyl ester, (2R)-
- 中文名:
- 依利曲坦中间体
- 中文别名:
- 依利曲坦中间体;(R)-2-(5-溴-1H-吲哚-3-羰基)吡咯烷-1-羧酸苄酯;(R)-2-[(5-溴-1H-吲哚-3-基)羰基]-1-吡咯烷甲酸苄酯
- CBNumber:
- CB32129544
- 分子式:
- C21H19BrN2O3
- 分子量:
- 427.29
- MOL File:
- 143322-56-9.mol
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依利曲坦中间体化学性质
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沸点:
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605.0±55.0 °C(Predicted)
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密度:
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1.505
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储存条件:
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2-8°C
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溶解度:
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soluble in Dichloromethanol, Ethyl Acetate, Methanol
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形态:
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Solid
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酸度系数(pKa):
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14.40±0.30(Predicted)
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颜色:
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White
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CAS 数据库:
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143322-56-9(CAS DataBase Reference)
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依利曲坦中间体性质、用途与生产工艺
国内外公开的依立曲坦中间体(R)-3-(N-苄氧羰基吡咯烷-2-基羰基)-5-溴-1H-吲哚的制备方法仅有上述报道，此方法使用格氏试剂-乙基溴化镁作为缩合剂，存在诸多缺点：格氏试剂性质不稳定；制备操作条件要求高，存在安全隐患；市场所售成品的含量不稳定，质量差且成本较贵，反应区域选择性差，生成较多1位取代的副产物，导致收率及纯度偏低，所以不适合大规模工业化生产制备。
依利曲坦中间体
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143322-56-9, 依利曲坦中间体 相关搜索:
- Pharmaceuticals
- Intermediates & Fine Chemicals
- Indole Derivatives
- Chiral Reagents
- 163322-57-0
- (R)-2-(5-溴-1H-吲哚-3-羰基)吡咯烷-1-羧酸苄酯
- (R)-2-[(5-溴-1H-吲哚-3-基)羰基]-1-吡咯烷甲酸苄酯
- 依利曲坦中间体
- 143322-56-9
- (5R)3-(N-benzyloxycarbonyl-D-prolyl)-5-bromoindole
- 3-(N- benzyloxycarbonyl-D-prolyl)-5-bromoindole
- (R)-(5-bromo-1H-indol-3-yl)[N-[(phenylmethoxy)carbonyl]-2-pyrrolidinyl]methanone
- 1-Pyrrolidinecarboxylic acid, 2-[(5-bromo-1H-indol-3-yl)carbonyl]-, phenylmethyl ester, (2R)-
- 1-Pyrrolidinecarboxylic acid, 2-[(5-bromo-1H-indol-3-yl)carbonyl]-, phenylmethyl ester, (R)-
- (R)-Benzyl 2-(5-bromo-1H-indole-3-carbonyl)-pyrrolidine-1-carboxylate
- InterMediate of Eletriptan
- (2R)-2-[(5-BroMo-1H-indol-3-yl)carbonyl]-1-pyrrolidinecarboxylic Acid PhenylMethyl Ester
- (R)-2-[(5-Bromo-1H-indol-3-yl)carbonyl]-1-pyrrolidinecarboxylic acid benzyl ester
- (R)-5-bromo-3-[(1-methyl-2-pyrrolidinyl)methyl]-1H-indole