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(E)-2'-DEOXY-2'-(FLUOROMETHYLENE) CYTIDINE
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- CAS号:
- 130306-02-4
- 英文名:
- (E)-2'-DEOXY-2'-(FLUOROMETHYLENE) CYTIDINE
- 英文别名:
- tezaciabine;(E)-2'-DEOXY-2'-(FLUOROMETHYLENE) CYTIDINE;2'-deoxy-2'-(fluoromethylene)-(2E)Cytidine;Cytidine, 2'-deoxy-2'-(fluoromethylene)-, (2'E)-
- 中文名:
- (E)-2'-DEOXY-2'-(FLUOROMETHYLENE) CYTIDINE
- 中文别名:
- 替扎西他滨;化合物 TEZACITABINE
- CBNumber:
- CB3221204
- 分子式:
- C10H12FN3O4
- 分子量:
- 257.22
- MOL File:
- 130306-02-4.mol
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(E)-2'-DEOXY-2'-(FLUOROMETHYLENE) CYTIDINE化学性质
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沸点:
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512.5±60.0 °C(Predicted)
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密度:
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1.71±0.1 g/cm3(Predicted)
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储存条件:
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-80°C
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溶解度:
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DMSO : 200 mg/mL (777.54 mM; Need ultrasonic)
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酸度系数(pKa):
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12.50±0.60(Predicted)
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(E)-2'-DEOXY-2'-(FLUOROMETHYLENE) CYTIDINE性质、用途与生产工艺
Tezacitabine 是一种具有细胞生长抑制和细胞毒性的抗代谢药，是一种核苷类似物。Tezacitabine 不可逆地抑制核糖核苷酸还原酶 (ribonucleotide reductase) 并干扰 DNA 复制和修复。Tezacitabine 有效诱导细胞凋亡 (apoptotic)，可用于白血病和实体瘤的研究。
Tezacitabine (0.01-10 µM; 24 hours; CCRF-SB, KG-1, Jurkat, COLO-205, MCF-7 and PC-3 cells) treatment induces the G1 and S-phase leaky block of the cell cycle.
Tezacitabine (0.01-10 µM; 24 hours; CCRF-SB, KG-1, Jurkat, COLO-205, MCF-7 and PC-3 cells) treatment apoptotic death of cells by the caspase 3/7 pathway in a concentration-dependent manner.
Tezacitabine has strong cytostatic and cytotoxic properties. Cytotoxic effect of Tezacitabine reveals not only as apoptosis, but also as a change in protein metabolism.
Cell Cycle Analysis
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Cell Line:
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CCRF-SB, KG-1, Jurkat, COLO-205, MCF-7 and PC-3 cells
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Concentration:
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0.01 µM, 0.1 µM, 1.0 µM, and 10 µM
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Incubation Time:
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24 hours
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Result:
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Induced the G1 (at concentrations higher than 10 nM) and S-phase (at low concentration) leaky block of the cell cycle.
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Apoptosis Analysis
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Cell Line:
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CCRF-SB, KG-1, Jurkat, COLO-205, MCF-7 and PC-3 cells
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Concentration:
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0.01 µM, 0.1 µM, 1.0 µM, and 10 µM
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Incubation Time:
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24 hours
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Result:
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Induced apoptotic death of cells by the caspase 3/7 pathway in a concentration-dependent manner.
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Tezacitabine (100 mg/kg; intraperitoneal injection; daily; female nude mice) treatment inhibits tumor growth in HCT 116 tumor xenografts.
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Animal Model:
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Female nude mice (7-9-week-old) injected with HCT 116 cells
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Dosage:
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100 mg/kg
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Administration:
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Intraperitoneal injection; daily; 14 days
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Result:
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Inhibited tumor growth in HCT 116 tumor xenografts.
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(E)-2'-DEOXY-2'-(FLUOROMETHYLENE) CYTIDINE
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130306-02-4, (E)-2'-DEOXY-2'-(FLUOROMETHYLENE) CYTIDINE 相关搜索:
- C10H12FN3O4
- 化合物 TEZACITABINE
- 替扎西他滨
- 130306-02-4
- 2'-deoxy-2'-(fluoromethylene)-(2E)Cytidine
- Cytidine, 2'-deoxy-2'-(fluoromethylene)-, (2'E)-
- tezaciabine
- (E)-2'-DEOXY-2'-(FLUOROMETHYLENE) CYTIDINE