氯塞酮
|
|
|
- CAS号:
- 77-36-1
- 英文名:
- Chlortalidone
- 英文别名:
- renon;g33182;isoren;oradil;igroton;hygroton;hydroton;oxodolin;zambesil;NSC 6920
- 中文名:
- 氯塞酮
- 中文别名:
- 氯塞酮;氯噻酮;氯赛酮;氯泰酮;氯吡酮杂质;氯赛酮 标准品;氯噻酮-氯塞酮;氯塞酮(氯噻酮);氯塞酮 EP标准品;氯噻酮 USP标准品
- CBNumber:
- CB3233539
- 分子式:
- C14H11ClN2O4S
- 分子量:
- 338.77
- MOL File:
- 77-36-1.mol
|
|
|
氯塞酮性质、用途与生产工艺
Chlortalidone (Chlortalidone)是一种利尿剂，用于治疗高血压。
Chlorthalidone通过抑制钠离子通过肾小管上皮细胞的转运，增加钠，氯，和水排泄到肾内腔。它作用的主要位点是髓袢上升支的皮质稀释段。通过增加钠到远端肾小管的转运，chlorthalidone通过钠钾交换机制间接增加钾分泌(即顶端ROMK/Na 通道耦合基底侧NKATPases)。
Chlorthalidone is a thiazide-like diuretic. After oral intake, peak serum concentrations are achieved in 2-6 hours. The half-life of Chlorthalidone is approximately 42 (range 29-55) hours, reaching 45-60 hours after long-term dosing. However, interindividual variability in the half-life of Chlorthalidone is wide. Chlorthalidone is excreted unchanged by the kidneys. The natriuretic effect of Chlorthalidone is maximal at 18 hours and lasts more than 48 hours. Comparing different doses of Chlorthalidone, it has been observed that 25 mg daily is nearly as effective as higher doses, but with less risk of hypokalemia. Chlorthalidone reduces calcium oxalate calculous recurrence but magnesium hydroxide does not. The effectiveness of Chlorthalidone or magnesium hydroxide is examined in the prevention of recurrent calcium oxalate kidney calculi. In a double-blind random allocation design daily dosages of 25 or 50 mg. Chlorthalidone, 650 or 1,300 mg. magnesium hydroxide, or an identical placebo are administered. All groups showed significantly decreased calculous events compared to the pretreatment rates. During the trial 56.1 per cent fewer calculi than predicted developed in the placebo group (p less than 0.01), whereas the groups receiving low and high dosage magnesium hydroxide showed 73.9 and 62.3 per cent fewer calculi, respectively (p less than 0.001 and less than 0.01, respectively). Chlorthalidone treatment results in a 90.1 per cent decrease from predicted rates and both dosages yielded similar results. When the treatments are compared Chlorthalidone is significantly better than the placebo or magnesium hydroxide (p less than 0.01). The large decreases in calculous events seen when placebo or ineffective therapy is given underscore the positive treatment bias that occurs when historical controls are used and they demonstrate the need for proper experimental design.
化学性质
白色结晶性粉末。熔点224-226℃（分解）。微溶于水、乙醇、氯仿，溶于热乙醇。无臭，无味。
用途
利尿药，用于心脏性，肾性及其他水肿病。
生产方法
由2-（3-氨基-4-氯苯甲酰）苯甲酸[118-04-7]经重氮化、置换、氯磺化、环合、胺化而得。
氯塞酮
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-15833 | 氯塞酮
Chlorthalidone | 77-36-1 | 50mg | 200元 |
| 2024/01/25 | HY-15833 | 氯塞酮
Chlorthalidone | 77-36-1 | 10mM * 1mLin DMSO | 220元 |
氯塞酮
生产厂家
全球有 247家供应商
氯塞酮国内生产厂家
77-36-1, 氯塞酮 相关搜索:
- Neat Compounds
- Drugs&Metabolites
- C
- Alphabetic
- CHForensic and Veterinary Standards
- Sulfur & Selenium Compounds
- Pharmaceuticals
- Intermediates & Fine Chemicals
- Heterocycles
- Amines
- THALITONE
- FDA批准的配体
- 标准品
- 化学试剂
- 试剂盒-Elisa试剂盒
- 医用原料
- 原料
- 农药原料
- 医药原料药-科研原料
- 有机中间体
- 有机化学
- 无机化合物和盐
- 小分子抑制剂
- 原料药
- Alphabetic
- Analytical Chromatography Product Catalog
- Analytical Standards
- CH
- 338766
- C14H11ClN2O4S
- PERFEMIKER]氯塞酮,98%
- 氯泰酮
- 氯噻酮-氯塞酮
- 氯赛酮
- 氯塞酮 EP标准品
- 氯塞酮峰鉴别 EP标准品
- 氯赛酮CHLORTALIDONE
- 氯赛酮 标准品
- 氯噻酮 USP标准品
- 氯吡酮杂质
- 氯噻酮溶液,1000PPM
- 氯噻酮溶液,100PPM
- 氯噻酮
- 氯塞酮(氯噻酮)
- 氯塞酮/2-氯-5-(2,3-二氢-1-羟基-3-氧代-1H-异吲哚-1-基)苯磺酰胺
- 氯塞酮
- 2-氯-5-(2,3-二氢-1-羟基-3-氧代-1H-异吲哚-1-基)苯磺酰胺
- 77-36-1
- Clorthalidone Reference Standard
- Chlorthalidone API
- Chlortalidone
2-Chloro-5-(1-hydroxy-3-oxo-1-
isoindolinyl)benzenesulfonamide
- 2-chloro-5-(1-hydroxy-3-oxo-2H-isoindol-1-yl)benzenesulfonamide (chlorotalidone)
- 2-c h loro-5-[(1RS)-1-h yd roxy-3-oxo-2,3-d i h yd ro-1h -i soi nd ol-1-yl]b e nze ne sulf ona mi d e
- Chlorthalidone (1130006)
- TIANFUCHEM--77-36-1,Chlortalidone
- ChlorthalidoneQ: What is
Chlorthalidone Q: What is the CAS Number of
Chlorthalidone Q: What is the storage condition of
Chlorthalidone Q: What are the applications of
Chlorthalidone
- Chlortalidoner
- Chlortalidone USP/EP/BP