AC-5216
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- CAS号:
- 226954-04-7
- 英文名:
- AC-5216
- 英文别名:
- CS-2606;AC-5216;XBD-173;Mapunil;EMapunil;AC-5216,XBD-173;Emapunil(AC-5216);AC 5216 (Emapunil);XBD173 >=98% (HPLC);AC-5216;XBD-173;EMAPUNIL;AC5216;AC 5216
- 中文名:
- AC-5216
- 中文别名:
- 依马普尼;EMAPUNIL游离;EMAPUNIL游离态;AC 5216,TSPO配体;N-乙基-7,8-二氢-7-甲基-8-氧代-2-苯基-N-(苯基甲基)-9H-嘌呤-9-乙酰胺;N-苄基-N-乙基-2-(7-甲基-8-氧代-2-苯基-7,8-二氢-9H-嘌呤-9-基)乙酰胺
- CBNumber:
- CB32448636
- 分子式:
- C23H23N5O2
- 分子量:
- 401.46
- MOL File:
- 226954-04-7.mol
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AC-5216化学性质
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储存条件:
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2-8°C
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溶解度:
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DMF: 30 mg/mL; DMF:PBS (pH 7.2) (1:20): 0.05 mg/mL; DMSO: 5 mg/mL
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形态:
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powder
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颜色:
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white to beige
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AC-5216性质、用途与生产工艺
Emapunil (AC-5216, 18 kiloDalton Translocator Protein, XBD173)是一种新型的 mitochondrial benzodiazepine receptor/translocator protein (MBR/TSPO) 配体。Emapunil(AC-5216) 对大鼠全脑制备的 MBRs 具有高亲和力，Ki值为0.297 nM，在大鼠神经胶质瘤细胞和人神经胶质瘤细胞上的IC50值分别为 3.04 nM和 2.73 nM。
| Target | Value |
mMBR(Brain)
(Cell-free assay)
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0.297 nM(Ki)
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MBR
(human glioma cells-based assay)
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2.73 nM
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MBR
(rat glioma cells-based assay)
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3.04 nM
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Emapunil (AC-5216, 0.1-3, 0.003-0.01 and 0.01-0.3 mg/kg, p.o.) produces anti-anxiety effects in the Vogel-type conflict test in rats, and in the light/dark box and social interaction tests in mice.
Emapunil (AC-5216, 3-30 mg/kg, p.o.) reduces the immobility time, and this effect was blocked by PK11195.
Emapunil (AC-5216, 1-100 mg/kg, p.o.) produces no distinct change in the rat electroencephalogram.
Emapunil (AC-5216, 0.3 and 1 mg/kg, i.g.) causes significant suppression of the enhanced anxiety and contextual fear induced in post-TDS rats.
Emapunil (AC-5216, 0.3 and 1 mg/kg, i.g.) alleviates the enhanced anxiety and fear response in a time-dependent sensitization (TDS) procedure, a rat PTSD animal model.
Emapunil (AC-5216, 0.3 and 1 mg/kg, i.g.) reverses the increased plasma glucose (PG) and decreased insulin (INS) in HFD-STZ rats.
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Animal Model:
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Rats.
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Dosage:
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0.1-3 mg/kg.
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Administration:
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P.O..
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Result:
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Significantly increased the number of shocks that rats received.
Significantly increased the time spent in the light compartment but only slightly increased that time at 0.03 mg/kg, p.o. (P<0.1).
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AC-5216
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-15527 | Emapunil | | 1 mg | 500元 |
| 2024/01/25 | HY-15527 | Emapunil | 226954-04-7 | 5mg | 1100元 |
226954-04-7, AC-5216 相关搜索:
- Inhibitors
- 合成有机化合物配体
- 生物试剂
- 活性分子
- 小分子抑制剂，天然产物
- 小分子抑制剂
- AC 5216,TSPO配体
- 依马普尼
- N-乙基-7,8-二氢-7-甲基-8-氧代-2-苯基-N-(苯基甲基)-9H-嘌呤-9-乙酰胺
- N-苄基-N-乙基-2-(7-甲基-8-氧代-2-苯基-7,8-二氢-9H-嘌呤-9-基)乙酰胺
- EMAPUNIL游离
- EMAPUNIL游离态
- 226954-04-7
- AC-5216,XBD-173
- PTSD,depression,T2DM,AC 5216,antianxiety,Emapunil,XBD 173,disorder,traumatic,MBR,neuroprotective,inhibit,post,XBD173,Antidepressant,AC5216,Inhibitor,stress,anti-inflammatory
- N-benzyl-N-ethyl-2-(7-methyl-8-oxo-2-phenyl-7H-purin-9(8H)-yl)acetamide
- Mapunil
- 9H-Purine-9-acetaMide,N-ethyl-7,8-dihydro-7-Methyl-8-oxoChemicalbook-2-phenyl-N-(phenylMethyl)-
- XBD173 >=98% (HPLC)
- AC-5216;XBD-173;EMAPUNIL;AC5216;AC 5216
- CS-2606
- AC-5216
- Emapunil(AC-5216)
- N-Ethyl-7,8-dihydro-7-methyl-8-oxo-2-phenyl-N-(phenylmethyl)-9H-purine-9-acetamide
- AC 5216 (Emapunil)
- 9H-Purine-9-acetaMide,N-ethyl-7,8-dihydro-7-Methyl-8-oxo-2-phenyl-N-(phenylMethyl)-
- N-Benzyl-N-ethyl-2-(7-Methyl-8-oxo-2-phenyl-7,8-dihydro-9H-purin-9-yl)acetaMide
- XBD-173
- EMapunil