STAT5 Inhibitor
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- CAS号:
- 285986-31-4
- 英文名:
- STAT5 Inhibitor
- 英文别名:
- MDK6314;CS-2509;STAT5-IN-1;STAT5 Inhibitor;STAT5 Inhibitor 1;Stat5 Inhibitor(STAT5-IN-1);N'-[(4-oxo-4H-chromen-3-yl)methylene]nicotinohydrazide;STAT-5-IN-1,STAT5IN1,inhibit,STAT5 IN 1,Inhibitor,STAT;N'-((4-Oxo-4H-chromen-3-yl)methylene)nicotinohydrazide;(E)-N'-((4-oxo-4H-chromen-3-yl)methylene)nicotinohydrazide
- 中文名:
- STAT5 Inhibitor
- 中文别名:
- STAT5抑制剂;化合物STAT5 INHIBITOR;优选]STAT5 INHIBITOR;STAT5抑制剂(STAT5-IN-1);N'-((4-氧代-4H-苯并吡喃-3-基)亚甲基)烟肼;N'-((4-氧代-4H-苯并吡喃-3-基)亚甲基)烟肼
- CBNumber:
- CB32515923
- 分子式:
- C16H11N3O3
- 分子量:
- 293.28
- MOL File:
- 285986-31-4.mol
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STAT5 Inhibitor化学性质
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熔点:
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214-216 °C
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密度:
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1.33±0.1 g/cm3(Predicted)
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储存条件:
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2-8°C(protect from light)
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溶解度:
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≥9.58 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
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形态:
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crystalline solid
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酸度系数(pKa):
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10.44±0.46(Predicted)
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STAT5 Inhibitor性质、用途与生产工艺
STAT5-IN-1 是一种有效的选择性 STAT5 抑制剂，其对于STAT5β亚型的IC50值为47 μM。
| Target | Value |
STAT5β
(Cell-free assay)
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47 μM
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The signal transducer and activator of transcription 5 (STAT5) is a member of the STAT family of proteins, implicated in cell growth and differentiation. STAT5-IN-1 inhibits STAT5 by binding to the SH2 domain. The functions of the SH2 domains of STAT3, STAT1, and of the tyrosine kinase Lck are inhibited to a lesser extent (IC50>500 µM). STAT5-IN-1 block STAT5/STAT5 DNA binding in K562 nuclear extracts. Substitution of the hydrogen at C6 of the chromone ring by an ethyl group does not affect activity of STAT5-IN-1 against STAT5β, but leads to complete loss of selectivity against other STAT family members.
STAT5 Inhibitor
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-101853 | STAT5 Inhibitor
STAT5-IN-1 | 285986-31-4 | 5mg | 550元 |
| 2024/01/25 | HY-101853 | STAT5 Inhibitor
STAT5-IN-1 | 285986-31-4 | 10mM * 1mLin DMSO | 605元 |
285986-31-4, STAT5 Inhibitor 相关搜索:
- 药靶配体
- 细胞生物学试剂
- N'-((4-氧代-4H-苯并吡喃-3-基)亚甲基)烟肼
- 优选]STAT5 INHIBITOR
- N'-((4-氧代-4H-苯并吡喃-3-基)亚甲基)烟肼
- 化合物STAT5 INHIBITOR
- STAT5抑制剂
- STAT5抑制剂(STAT5-IN-1)
- 285986-31-4
- N'-((4-Oxo-4H-chromen-3-yl)methylene)nicotinohydrazide
- N'3-[(4-oxo-4H-chromen-3-yl)methylidene]pyridine-3-carbohydrazide
- Stat5 Inhibitor(STAT5-IN-1)
- STAT-5-IN-1,STAT5IN1,inhibit,STAT5 IN 1,Inhibitor,STAT
- 3-Pyridinecarboxylic acid, 2-[(4-oxo-4H-1-benzopyran-3-yl)methylene]hydrazide
- MDK6314
- (E)-N'-((4-oxo-4H-chromen-3-yl)methylene)nicotinohydrazide
- STAT5 Inhibitor 1
- CS-2509
- STAT5 Inhibitor
- N'-[(4-oxo-4H-chromen-3-yl)methylene]nicotinohydrazide
- STAT5-IN-1