G15;G-15;G 15;1161002-05-6
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- CAS号:
- 1161002-05-6
- 英文名:
- (3aS*,4R*,9bR*)-4-(6-Bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta[c]quinoline
- 英文别名:
- H37;G-15;RMB5;LUCA15;AGPAT1;1-AGPAT1;LPAAT-alpha;G15;G-15;G 15;1161002-05-6;RNA binding motif protein 5;Compound G15 - GPR30 antagonist
- 中文名:
- G15;G-15;G 15;1161002-05-6
- 中文别名:
- 15国集团;化合物G15;G-15,GPER拮抗剂;ANTI-AGPAT1 ANTIBODY-溶血磷脂酰基转移酶抗体;(3AS,4R,9BR)-4-(6-溴苯并[D][1,3]二恶英-5-基)-3A,4,5,9B-四氢-3H-环戊烷[C]喹啉
- CBNumber:
- CB32518797
- 分子式:
- C19H16BrNO2
- 分子量:
- 370.24
- MOL File:
- 1161002-05-6.mol
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G15;G-15;G 15;1161002-05-6化学性质
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熔点:
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178-180 °C
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沸点:
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462.7±45.0 °C(Predicted)
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密度:
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1.472±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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insoluble in H2O; insoluble in EtOH; ≥37 mg/mL in DMSO
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形态:
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solid
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酸度系数(pKa):
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3.98±0.40(Predicted)
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G15;G-15;G 15;1161002-05-6性质、用途与生产工艺
G15是一种高亲和力、选择性的G-protein coupled estrogen receptor 1 (GPER, GPR30) 拮抗剂，约20 nM的结合亲和力，在浓度高达10 μM时，对ERα和ERβ没有亲和力。
G15 (0.1-10 μM; 2 days) inhibits GPER-mediated proliferation stimulated by 17β-estradiol (E2) in A549 and H1793 cell lines.
G15 (1 μM; 48 hours) inhibits the response of GPER stimulated by E2 and G1 in A549 and H1793 cell lines.
Cell Proliferation Assay
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Cell Line:
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A549, H1793 cell lines
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Concentration:
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0.1, 1, 10 μM (combination with 10 nM E2)
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Incubation Time:
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2 days
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Result:
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Inhibited GPER-mediated proliferation stimulated by E2.
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Western Blot Analysis
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Cell Line:
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A549, H1793 cell lines
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Concentration:
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1 μM (combination with 10 nM E2 and 10 nM G1)
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Incubation Time:
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48 hours
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Result:
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Inhibited the response of GPER stimulated by E2 and G1.
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G15 (1.46 mg/kg; i.h.; twice a week for 14 weeks) decreases the number of tumor nodules and tumor index increased by the E2 or G1 group in urethane-induced adenocarcinoma mice.
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Animal Model:
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Four-week-old female Kunming mice (Urethane-induced adenocarcinoma)
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Dosage:
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1.46 mg/kg (combination with E2, 0.09 mg/kg and fulvestrant (Ful), 2.4 mg/kg)
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Administration:
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Subcutaneous injection; twice a week for 14 weeks
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Result:
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The number of tumor nodules decreased in the E2+Ful+G15 group.
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G15;G-15;G 15;1161002-05-6
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-103449 | G15 | | 1 mg | 323元 |
| 2024/01/25 | HY-103449 | G15;G-15;G 15;1161002-05-6
G15 | 1161002-05-6 | 5mg | 712元 |
G15;G-15;G 15;1161002-05-6
生产厂家
1161002-05-6, G15;G-15;G 15;1161002-05-6 相关搜索:
- 合成有机化合物配体
- 小分子
- 试剂盒-细胞分析试剂盒
- G-15,GPER拮抗剂
- ANTI-AGPAT1 ANTIBODY-溶血磷脂酰基转移酶抗体
- 15国集团
- 化合物G15
- (3AS,4R,9BR)-4-(6-溴苯并[D][1,3]二恶英-5-基)-3A,4,5,9B-四氢-3H-环戊烷[C]喹啉
- 1161002-05-6
- Inhibitor,inhibit,G-15,G15,Estrogen Receptor/ERR,G 15
- (3aS,4R,9bR)-4-(6-bromobenzo[d][1,3]dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline
- Compound G15 - GPR30 antagonist
- 3H-Cyclopenta[c]quinoline, 4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-tetrahydro-, (3aS,4R,9bR)-
- (3aS,4R,9bR)-4-(6-Bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline (G-15)
- (3aR,4R,9bS)-4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline
- G15;G-15;G 15;1161002-05-6
- (3aS*,4R*,9bR*)-4-(6-Bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta[c]quinoline
- LPAAT-alpha
- Anti-AGPAT1 antibody produced in rabbit
- AGPAT1
- 1-AGPAT1
- RNA binding motif protein 5
- RMB5
- LUCA15
- H37
- (3aS,4R,9bR)-4-(6-BroMo-1,3-benzodioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline
- G-15