CS-1226
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- CAS号:
- 431979-47-4
- 英文名:
- 2-[2-Chloro-4-[(1,5-dihydro-3-methyl-5-oxo-1-phenyl-4H-pyrazol-4-ylidene)methyl]-6-ethoxyphenoxy]aceticacidmethylester
- 英文别名:
- CS-1226;SJ 172550;MDMX Antagonist, SJ-172550;MDMX Antagonist, SJ-172550 - CAS 431979-47-4 - Calbiochem;Methyl 2-(2-chloro-6-ethoxy-4-((3-methyl-5-oxo-1-phenyl-1H-pyrazol-4(5H)-ylidene)methyl)phenoxy)acetate;2-[2-Chloro-4-[(1,5-dihydro-3-methyl-5-oxo-1-phenyl-4H-pyrazol-4-ylidene)methyl]-6-ethoxyphenoxy]aceticacidmethylester;Acetic acid, 2-[2-chloro-4-[(1,5-dihydro-3-methyl-5-oxo-1-phenyl-4H-pyrazol-4-ylidene)methyl]-6-ethoxyphenoxy]-, methyl ester;E3 ligating enzyme,Ubiquitin activating enzyme,E2 conjugating enzyme,E1/E2/E3 Enzyme,MDM-2/p53,Ubiquitin ligase,SJ172550,E1 activating enzyme,SJ 172550,SJ-172550,inhibit,Ubiquitin conjugating enzyme,Inhibitor
- 中文名:
- CS-1226
- 中文别名:
- 化合物SJ-172550;MDMX小分子抑制剂(SJ-172550);2-(2-氯-6-乙氧基-4-((3-甲基-5-氧代-1-苯基-1H-吡唑-4(5H)-亚基)甲基)苯氧基)乙酸甲酯
- CBNumber:
- CB32518904
- 分子式:
- C22H21ClN2O5
- 分子量:
- 428.87
- MOL File:
- 431979-47-4.mol
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CS-1226化学性质
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沸点:
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560.8±60.0 °C(Predicted)
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密度:
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1.27±0.1 g/cm3(Predicted)
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储存条件:
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Sealed in dry,2-8°C
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溶解度:
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DMSO: ≥30mg/mL
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酸度系数(pKa):
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-0.30±0.40(Predicted)
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形态:
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powder
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颜色:
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orange
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CS-1226性质、用途与生产工艺
SJ-172550是MDMX的小分子抑制剂; 与野生型p53肽竞争性结合于MDMX的EC50值为5 μM。
The p53 pathway is disrupted in virtually every human tumor. SJ-172550 binds the p53-binding pocket of MDMX, thereby displacing p53. SJ-172550 binds reversibly to MDMX and effectively kills retinoblastoma cells in which the expression of MDMX is amplified. The effect of SJ-172550 is additive when combined with an MDM2 inhibitor nutlin-3a. SJ-172550 acts through a complicated mechanism in which the compound forms a covalent but reversible complex with MDMX and locks MDMX into a conformation that is unable to bind p53. The relative stability of this complex is influenced by many factors including the reducing potential of the media, the presence of aggregates.
CS-1226
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/01/25 | HY-16664 | SJ-172550 | | 1 mg | 360元 |
2024/01/25 | HY-16664 | CS-1226 SJ-172550 | 431979-47-4 | 5mg | 675元 |
431979-47-4, CS-1226 相关搜索:
- 细胞生物学试剂
- 2-(2-氯-6-乙氧基-4-((3-甲基-5-氧代-1-苯基-1H-吡唑-4(5H)-亚基)甲基)苯氧基)乙酸甲酯
- 化合物SJ-172550
- MDMX小分子抑制剂(SJ-172550)
- 431979-47-4
- E3 ligating enzyme,Ubiquitin activating enzyme,E2 conjugating enzyme,E1/E2/E3 Enzyme,MDM-2/p53,Ubiquitin ligase,SJ172550,E1 activating enzyme,SJ 172550,SJ-172550,inhibit,Ubiquitin conjugating enzyme,Inhibitor
- Methyl 2-(2-chloro-6-ethoxy-4-((3-methyl-5-oxo-1-phenyl-1H-pyrazol-4(5H)-ylidene)methyl)phenoxy)acetate
- Acetic acid, 2-[2-chloro-4-[(1,5-dihydro-3-methyl-5-oxo-1-phenyl-4H-pyrazol-4-ylidene)methyl]-6-ethoxyphenoxy]-, methyl ester
- MDMX Antagonist, SJ-172550 - CAS 431979-47-4 - Calbiochem
- CS-1226
- MDMX Antagonist, SJ-172550
- SJ 172550
- 2-[2-Chloro-4-[(1,5-dihydro-3-methyl-5-oxo-1-phenyl-4H-pyrazol-4-ylidene)methyl]-6-ethoxyphenoxy]aceticacidmethylester