4-[1-环己基-4-(4-氟苯基)-1H-咪唑-5-基]-2-嘧啶胺盐酸盐
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- CAS号:
- 950912-80-8
- 英文名:
- 4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinaminedihydrochloride
- 英文别名:
- CS-318;PF 67046;PF 670462;PF-670462 HCL;PF-670462 2HCl;PF 670462, >=98%;PF670462/ PF-670462;PF670462 dihydrochloride;PF-670462 (hydrochloride);Casein Kinase I Inhibitor II, PF-670462
- 中文名:
- 4-[1-环己基-4-(4-氟苯基)-1H-咪唑-5-基]-2-嘧啶胺盐酸盐
- 中文别名:
- 化合物PF670462;PF-670462盐酸盐;CK1Ε抑制剂(PF-670462);PF-670462,酪蛋白激酶1Ε(CK1Ε)和CK1Δ抑制剂;4-[1-环己基-4-(4-氟苯基)-1H-咪唑-5-基]-2-嘧啶胺盐酸盐;4-[1-环己基-4-(4-氟苯基)-1H-咪唑-5-基]-2-嘧啶胺二盐酸盐
- CBNumber:
- CB32518984
- 分子式:
- C19H20FN5.2HCl
- 分子量:
- 410
- MOL File:
- 950912-80-8.mol
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4-[1-环己基-4-(4-氟苯基)-1H-咪唑-5-基]-2-嘧啶胺盐酸盐化学性质
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熔点:
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>178°C (dec.)
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储存条件:
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2-8°C
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溶解度:
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H2O: soluble2mg/mL, clear (warmed)
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形态:
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powder
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颜色:
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white to beige
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InChIKey:
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PSNKGVAXBSAHCH-UHFFFAOYSA-N
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4-[1-环己基-4-(4-氟苯基)-1H-咪唑-5-基]-2-嘧啶胺盐酸盐性质、用途与生产工艺
PF-670462是有效的、选择性CK1ε和CK1δ抑制剂，IC50分别为90 nM和13 nM。
| Target | Value |
CK1δ
(Cell-free assay)
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13 nM
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CK1ε
(Cell-free assay)
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90 nM
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PF-670462 is a potent and selective inhibitor of CKIε and CKIδ, with IC
50
s of 7.7 nM and 14 nM, respectively. PF-670462 shows less than 30-fold selevtivity for EGFR and SAPK2A/p38, with IC
50
s of 150 nM and 190 nM, respectively. PF-670462 also causes a redistribution of the GFP signal to the cytoplasm in a concentration-dependent manner, with an EC
50
of 290 ± 39 nM in CKIε-transfected COS7 cells. PF-670462 is a potent inhibitor of Wnt/β-catenin signaling, with an IC
50
of ∼17 nM. PF-670462 (1 μM) is a weak inhibitor of proliferation, and only modestly suppresses the growth of HEK293 and HT1080 cells. PF-670462 (100 nM) strongly inhibits CK1ε and CK1δ, consistent with its effect on Wnt/β-catenin signaling.
PF-670462 (50 mg/kg, s.c.) produces robust phase delays, and the activity remains persistent, with no discernible correction in the absence of exogenous zeitgebers in rats. PF-670462 (25, 50, and 100 mg/kg, s.c.) induces dose-dependent phase shift. PF-670462 (50 mg/kg; s.c.) significantly phase delays the rhythmic transcription of Bmal1, Per1, Per2 and Nr1d1 in both liver and pancreas by 4.5 ± 1.3 h and 4.5 ± 1.2 h, respectively, 1 day after administration. In the suprachiasmatic nucleus (SCN), the rhythm of Nr1d1 and Dbp mRNA expression is also delayed by 4.2 and 4 h, respectively.
用途
PF 670462 is a potent and selective casein kinase(CK1ε) and CK1δ inhibitor. PF 670462 has been shown to inhibit PER protein nuclear translocation causing phase shifts in circadian rhythms. PF 6704
62 attenuates methamphetamine-stimulated locomotion in vivo.
4-[1-环己基-4-(4-氟苯基)-1H-咪唑-5-基]-2-嘧啶胺盐酸盐
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-15490 | PF-670462 dihydrochloride | | 1 mg | 348元 |
| 2024/01/25 | HY-15490 | PF-670462 dihydrochloride | | 5 mg | 767元 |
4-[1-环己基-4-(4-氟苯基)-1H-咪唑-5-基]-2-嘧啶胺盐酸盐
生产厂家
950912-80-8, 4-[1-环己基-4-(4-氟苯基)-1H-咪唑-5-基]-2-嘧啶胺盐酸盐 相关搜索:
- Protein Kinase Inhibitors and Activators
- Pharmaceuticals
- Intermediates & Fine Chemicals
- Heterocycles
- Aromatics
- Inhibitors
- 药靶配体
- 细胞生物学试剂
- 小分子抑制剂
- 抑制剂
- 信号转导通路激酶抑制剂
- 小分子抑制剂，天然产物
- C19H20FN52ClH
- C19H22Cl2FN5
- C19H20FN52HCl
- PF-670462,酪蛋白激酶1Ε(CK1Ε)和CK1Δ抑制剂
- 4-[1-环己基-4-(4-氟苯基)-1H-咪唑-5-基]-2-嘧啶胺二盐酸盐
- PF-670462盐酸盐
- 化合物PF670462
- CK1Ε抑制剂(PF-670462)
- 4-[1-环己基-4-(4-氟苯基)-1H-咪唑-5-基]-2-嘧啶胺盐酸盐
- 950912-80-8
- PF-670462 HCL
- PF670462 dihydrochloride
- CS-318
- 4-[1-cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]pyrimidin-2-amine dihydrochloride
- Casein Kinase I Inhibitor II, PF-670462 - CAS 950912-80-8 - Calbiochem
- 4-[3-cyclohexyl-5-(4-fluorophenyl)imidazol-4-yl]pyrimidin-2-amine:dihydrochloride
- 4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinaminedihydrochloride
- Casein Kinase I Inhibitor II, PF-670462
- PF-670462 (hydrochloride)
- PF-670462 2HCl
- PF 670462
- PF 670462, >=98%
- 4-[3-Cyclohexyl-5-(4-fluoro-phenyl)-3H-imidazol-4-yl]-pyrimidin-2-ylamine dihydrochloride
- 4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinamine hydrochloride PF670462
- PF 67046
- 2-PyriMidinaMine, 4-[1-cyclohexyl-4-(4-fluorophenyl)-1H-iMidazol-5-yl]-, hydrochloride (1:2)
- 4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinamine hydrochloride
- PF670462/ PF-670462