9-左氧氟沙星哌嗪杂质
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- CAS号:
- 178912-62-4
- 英文名:
- 9-Piperazino Levofloxacin
- 英文别名:
- Levofloxacin-16;Levofloxacin-004-S;PubChem ID: 71516447;Levofloacin Impurity 5;Levofloxacin Impurity M;Levofloxacin Impurity G01;9-Piperazino Levofloxacin;9-Piperazine Levofloxacin;Levofloxacin?EP Impurity I;Levofloxacin 9-Piperazinyl Isomer
- 中文名:
- 9-左氧氟沙星哌嗪杂质
- 中文别名:
- 左氧氟沙星杂质G;9-左氧氟沙星哌嗪;左氧氟沙星杂质G01;左氧氟沙星EP杂质I;9-哌嗪基左氧氟沙星;左氧氟沙星氯化钠杂质I;左氧氟沙星标准品4-S;9-哌嗪左氧氟沙星杂质;9-左氧氟沙星哌嗪杂质;左氧氟沙星9哌嗪基异构体
- CBNumber:
- CB32544985
- 分子式:
- C18H20FN3O4
- 分子量:
- 361.37
- MOL File:
- 178912-62-4.mol
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9-左氧氟沙星哌嗪杂质化学性质
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沸点:
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588.1±50.0 °C(Predicted)
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密度:
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1.48±0.1 g/cm3(Predicted)
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溶解度:
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Chloroform (Sparingly), DMSO (Slightly)
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形态:
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Solid
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酸度系数(pKa):
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5.28±0.40(Predicted)
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颜色:
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Light Yellow to Yellow
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9-左氧氟沙星哌嗪杂质性质、用途与生产工艺
氟喹诺酮类药物以其广谱、高效、低毒的抗菌特性，在临床抗感染治疗上取得了巨大的成功。其中以氧氟沙星、左氧氟沙星、盐酸左氧氟沙星为其中优秀的代表。日本第一三共制药有限公司开发的左氧氟沙星为市场占有率较广的优秀品种，化学名为：(-)-(S)-3-甲基-9-氟-2,3-二氢-10-(4-甲基-1-哌嗪基)-7-氧-7H-吡啶并[1,2,3-de]-[1,4]苯并噁嗪-6-羧酸)，为半水合物。左氧氟沙星的合成工艺已很成熟，报道文献很多，其中最后一步以缩哌反应合成左氧氟沙星。上述制备工艺中可能会产生位置异构的杂质(1)，化学名：(S)-(-)-10-氟-2,3-二氢-3-甲基-9-(4-甲基-1-哌嗪基)-7-氧代-7H-吡啶并[1,2,3-de]-[1,4]苯并噁嗪-6-羧酸，简称9-左氧氟沙星哌嗪杂质。
9-左氧氟沙星哌嗪杂质
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178912-62-4, 9-左氧氟沙星哌嗪杂质 相关搜索:
- Pharmaceuticals
- Intermediates & Fine Chemicals
- Impurities
- Heterocycles
- 化工试剂
- 016-左氧氟沙星
- 杂质对照品
- 杂质世界-左氧氟沙星
- 左氧氟沙星
- 对照品-杂质对照品
- 左氧氟沙星杂质4 (左氧氟沙星EP杂质I)
- 氧氟沙星EP杂质D(S-异构体)(9-哌嗪-左氧氟沙星杂质)
- (S)-10-氟-3-甲基-9-(4-甲基哌嗪-1-基)-7-氧-3,7-二氢-2H-[1,4]恶嗪[2,3,4-IJ]喹啉-6-羧酸 (氧氟沙星杂质)
- 氧氟沙星 EP 杂质 D(S-异构体)
- 杂质D(9-(4-甲基-1-哌嗪)左氧氟沙星) 178912-62-4
- 9-哌嗪基左氧氟沙星
- 左氧氟沙星氯化钠杂质I
- (S)-10-氟-2,3-二氢-3-甲基-9-(4-甲基-1-哌嗪基)-7-氧代-7H-吡啶基[1,2,3-DE]-1,4-苯并恶嗪-6-羧酸
- 9-哌嗪左氧氟沙星杂质
- 9-左氧氟沙星哌嗪
- 左氧氟沙星9哌嗪基异构体
- 左氧氟沙星EP杂质I
- 左氧氟沙星标准品4-S
- 左氧氟沙星杂质I(EP)
- 9-左氧氟沙星哌嗪杂质
- 左氧氟沙星杂质G
- 左氧氟沙星杂质G01
- 178912-62-4
- (S)-10-Fluoro-3-methyl-9-(4-methylpiperazin-1-yl)-7-oxo-3,7-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid (Ofloxacin Impurity)
- Levofloxacin Impurity 4 (Levofloxacin EP Impurity I)
- Levofloxacin EP Impurity I(9-Piperazine Levofloxacin Impurity)
- Ofloxacin EP Impurity D (S-Isomer)
- Levofloxacin EP Impurity I (Levofloxacin 9-Piperazinyl Isomer)
- 9-Piperazine Levofloxacin
- Ofloxacin EP Impurity D (S-Isomer) (9-Piperazine Levofloxacin Impurity)
- 7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, 10-fluoro-2,3-dihydro-3-methyl-9-(4-methyl-1-piperazinyl)-7-oxo-, (S)- (9CI)
- PubChem ID: 71516447
- Levofloxacin-004-S
- Levofloxacin?EP Impurity I
- Levofloxacin-16
- (S)-10-fluoro-3-methyl-9-(4-methylpiperazin-1-yl)
- Levofloacin Impurity 5
- Levofloxacin impurity 17/9-Piperazino Levofloxacin Impurity/Ofloxacin EP Impurity D /(S)-10-fluoro-3-methyl-9-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid
- Levofloxacin Impurity G01
- Levofloxacin Impurity M
- Levofloxacin 9-Piperazinyl Isomer
- (S)-10-fluoro-3-methyl-9-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid
- 9-Piperazino Levofloxacin
- 9-Piperazine Levofloxacin IMpurity
- 9-Piperazino Levofloxacin IMpurity