玻玛西林
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- CAS号:
- 1093403-33-8
- 英文名:
- SRT2104 (GSK2245840)
- 英文别名:
- CS-2293;GSK2245840;SRT-2104;SRT 2104;sirtuin Modulator;SRT2104 (GSK2245840);SRT2104 (GSK2245840) USP/EP/BP;SRT 2104,Sirtuin,Inhibitor,SRT-2104,inhibit;(E)-3-(3-HYDROXY-4-METHOXYPHENYL)PROP-2-ENOIC ACID;4-methyl-N-(2-(3-(morpholinomethyl)imidazo[2,1-b]thiazol-6-yl)phenyl)-2-(yridine-3-yl)thiazole-5-carboxamide;4-Methyl-N-[2-[3-(morpholinomethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-(pyridin-3-yl)thiazole-5-carboxamide
- 中文名:
- 玻玛西林
- 中文别名:
- 玻玛西林;化合物SRT2104;SRT 2104 选择性SIRT1活化剂;4-甲基-N-[2-[3-(吗啉基甲基)咪唑并[2,1-B]噻唑-6-基]苯基]-2-(吡啶-3-基)噻唑-5-酰胺;4-甲基-N-[2-[3-(吗啉基甲基)咪唑并[2,1-B]噻唑-6-基]苯基]-2-(吡啶-3-基)噻唑-5-甲酰胺;4-甲基-N-[2-[3-(4-吗啉基甲基)咪唑基[2,1-B]噻唑-6-基]苯基]-2-(3-吡啶基)-5-噻唑甲酰胺
- CBNumber:
- CB32624034
- 分子式:
- C26H24N6O2S2
- 分子量:
- 516.64
- MOL File:
- 1093403-33-8.mol
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玻玛西林化学性质
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密度:
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1.46±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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insoluble in H2O; insoluble in EtOH; ≥6.46 mg/mL in DMSO with gentle warming
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形态:
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Powder
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酸度系数(pKa):
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11.40±0.70(Predicted)
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玻玛西林性质、用途与生产工艺
SRT2104 (GSK2245840)是一种选择性 SIRT1 活化剂,参与能量平衡的调节。Phase 2。
SRT2104 reduces p65/RelA acetylation levels in C2C12 cells.
In male C57BL/6J mice, SRT2104 (100 mg/kg, p.o.) extends both mean and maximal lifespan of mice fed a standard diet, and enhances motor coordination, bone mineral density, and insulin sensitivity and decreased inflammation. Short-term SRT2104 treatment preserves bone and muscle mass in an experimental model of atrophy. In Male N171-82Q HD mice, SRT2104 (diet containing 0.5% SRT2104) effectively penetrates the blood-brain barrier, attenuates brain atrophy, improves motor function, and extends survival.
SRT2104 (GSK2245840)是一种选择性 SIRT1 活化剂,参与能量平衡的调节。Phase 2。
SRT2104降低C2C12细胞中p65/RelA乙酰化水平。
在雄性C57BL/6J小鼠体内,SRT2104 (100 mg/kg, p.o.)延长标准饮食喂养大鼠的平均和最大寿命,增强运动协调性,骨密度,和胰岛素敏感性,并减少炎症。在萎缩的实验模型中,短期SRT2104治疗保存骨头和肌肉质量。在雄性N171-82Q HD小鼠体内,SRT2104 (包含0.5% SRT2104的饮食)有效穿透血脑屏障,减弱脑萎缩,改善运动功能,并延长存活时间。
玻玛西林
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/01/16 | S7792 | 玻玛西林 SRT2104 (GSK2245840) | 1093403-33-8 | 5mg | 1193.94元 |
2024/01/16 | S7792 | 玻玛西林 SRT2104 (GSK2245840) | 1093403-33-8 | 25mg | 3904.54元 |
1093403-33-8, 玻玛西林 相关搜索:
- Inhibitors
- 合成有机化合物配体
- 小分子抑制剂,天然产物
- 4-甲基-N-[2-[3-(吗啉基甲基)咪唑并[2,1-B]噻唑-6-基]苯基]-2-(吡啶-3-基)噻唑-5-酰胺
- 化合物SRT2104
- 4-甲基-N-[2-[3-(4-吗啉基甲基)咪唑基[2,1-B]噻唑-6-基]苯基]-2-(3-吡啶基)-5-噻唑甲酰胺
- 玻玛西林
- SRT 2104 选择性SIRT1活化剂
- 4-甲基-N-[2-[3-(吗啉基甲基)咪唑并[2,1-B]噻唑-6-基]苯基]-2-(吡啶-3-基)噻唑-5-甲酰胺
- 1093403-33-8
- SRT 2104,Sirtuin,Inhibitor,SRT-2104,inhibit
- SRT2104 (GSK2245840) USP/EP/BP
- 4-methyl-N-[2-[3-(morpholin-4-ylmethyl)imidazo[2,1-b][1,3]thiazol-6-yl]phenyl]-2-pyridin-3-yl-1,3-thiazole-5-carboxamide
- 4-methyl-N-(2-(3-(morpholinomethyl)imidazo[2,1-b]thiazol-6-yl)phenyl)-2-(yridine-3-yl)thiazole-5-carboxamide
- SRT-2104;SRT 2104
- CS-2293
- GSK2245840
- 4-Methyl-N-[2-[3-(morpholinomethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-(pyridin-3-yl)thiazole-5-carboxamide
- sirtuin Modulator
- 5-ThiazolecarboxaMide, 4-Methyl-N-[2-[3-(4-MorpholinylMethyl)iMidazo[2,1-b]thiazol-6-yl]phenyl]-2-(3-pyridinyl)-
- (E)-3-(3-HYDROXY-4-METHOXYPHENYL)PROP-2-ENOIC ACID
- SRT2104 (GSK2245840)