ZK 159222
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- CAS号:
- 156965-15-0
- 英文名:
- ZK 159222
- 英文别名:
- ZK-15922;ZK 159222;ZK159222,ZK-159222;SPARTCPUGRJFRS-PBDCIXLPSA-N;Cholecalciferol Impurity 21;Vitamin D3 Impurity 21(Cholecalciferol Impurity 21);Cholecalciferol Impurity 21(Vitamin D3 Impurity 21);Cyclopropanecarboxylic acid, 1-[(1R,2E,4R)-4-[(1R,3aS,4E,7aR)-4-[(2Z)-2-[(3S,5R)-3,5-dihydroxy-2-methylenecyclohexylidene]ethylidene]octahydro-7a-methyl-1H-inden-1-yl]-1-hydroxy-2-penten-1-yl]-, butyl ester
- 中文名:
- ZK 159222
- 中文别名:
- 化合物 T17292;维生素D3杂质21(胆钙化醇杂质21);胆钙化醇杂质21(维生素D3杂质21)
- CBNumber:
- CB32709683
- 分子式:
- C32H48O5
- 分子量:
- 512.72
- MOL File:
- 156965-15-0.mol
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ZK 159222化学性质
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熔点:
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>62°C (dec.)
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沸点:
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646.3±55.0 °C(Predicted)
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密度:
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1.13±0.1 g/cm3(Predicted)
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储存条件:
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Amber Vial, -86°C Freezer, Under inert atmosphere
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溶解度:
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Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
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酸度系数(pKa):
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14.29±0.20(Predicted)
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形态:
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Solid
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颜色:
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Off-White to Pale Grey
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稳定性:
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Light Sensitive, Temperature Sensitive
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ZK 159222性质、用途与生产工艺
ZK159222 是 1α,25-(OH)2D3 的类似物，是有效的 1α,25-(OH)2D3 受体 (VDR) 拮抗剂。ZK159222 拮抗作用的机制是由配体诱导的维生素 D 受体与辅助激活剂的相互作用缺乏所介导的。ZK159222 具有部分激动性。
ZK159222, displayed the profile of a weak VDR agonists that requires an approximate 7-fold higher concentration than of the natural hormone 1α,25-(OH)2D3 to stabilize VDR-RXR heterodimer complex formation on a DR3-type VDRE. ZK159222 was found to belong to the category of 1α,25-(OH)2D3 analogues that stabilize an additional third functional VDR conformation, which has also been described for some agonistic 20-epi analogues. The remaining reporter gene activity that was obtained by a combined treatment of 10 nM 1α,25-(OH)2D3 with 1 μM ZK159222 is close to the partial agonistic activity of 1 μM ZK159222.
ZK 159222
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下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-12397 | ZK159222 | | 500 μg | 5900元 |
| 2024/01/25 | HY-12397 | ZK 159222
ZK159222 | 156965-15-0 | 1mg | 9800元 |
156965-15-0, ZK 159222 相关搜索:
- 维生素D3杂质21(胆钙化醇杂质21)
- 化合物 T17292
- 胆钙化醇杂质21(维生素D3杂质21)
- 156965-15-0
- Vitamin D3 Impurity 21(Cholecalciferol Impurity 21)
- Cholecalciferol Impurity 21(Vitamin D3 Impurity 21)
- ZK159222,ZK-159222
- Cholecalciferol Impurity 21
- Cyclopropanecarboxylic acid, 1-[(1R,2E,4R)-4-[(1R,3aS,4E,7aR)-4-[(2Z)-2-[(3S,5R)-3,5-dihydroxy-2-methylenecyclohexylidene]ethylidene]octahydro-7a-methyl-1H-inden-1-yl]-1-hydroxy-2-penten-1-yl]-, butyl ester
- ZK-15922
- SPARTCPUGRJFRS-PBDCIXLPSA-N
- ZK 159222