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6-CYANO-7-NITROQUINOXALINE-2;3-DIONE DISODIUM
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- CAS号:
- 479347-85-8
- 英文名:
- CNQX disodium salt
- 英文别名:
- 3-dione disodium;6-Cyano-7-nitroquinoxaline-2;7-Nitro-2,3-dioxo-1,2,3,4-tetrahydroquinoxaline-6-carbonitrile, disodium salt
- 中文名:
- 6-CYANO-7-NITROQUINOXALINE-2;3-DIONE DISODIUM
- 中文别名:
- CNQX二钠;CNQX二钠盐;7-硝基-2,3-二氧代-1,2,3,4-四氢喹喔啉-6-甲腈二钠盐
- CBNumber:
- CB33037190
- 分子式:
- C9H5N4NaO4
- 分子量:
- 256.15
- MOL File:
- 479347-85-8.mol
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6-CYANO-7-NITROQUINOXALINE-2;3-DIONE DISODIUM化学性质
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储存条件:
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Desiccate at RT
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溶解度:
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≥27.6 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
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形态:
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solid
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颜色:
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Brown or yellow
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水溶解性:
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Soluble to 20 mM in water
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6-CYANO-7-NITROQUINOXALINE-2;3-DIONE DISODIUM性质、用途与生产工艺
CNQX disodium (FG9065 disodium) 是一种有效的竞争性 AMPA /海藻酸酯受体 (AMPA/kainate receptor) 拮抗剂，IC50 分别为 0.3 μM 和 1.5 μM。CNQX disodium 是一种竞争性的非 NMDA 受体拮抗剂。CNQX disodium 会阻止大鼠恐惧增强的表达。
IC50: 0.3 μM (AMPA) and 1.5 μM (kainate receptor)
CNQX disodium (FG9065 disodium; 2-5 μM) reversibly blocks the Schaffer collateral and mossy fibre excitatory postsynaptic potential (EPSP), while sparing the fast and slow GABA-mediated inhibition in superfusion of hippocampal slices.
CNQX disodium (1-5 μM) produces a selective and dose-dependent reduction in the amplitude of the monosynaptic component of the DR-VRR recorded from lumbar spinal segments.
CNQX disodium (FG9065 disodium; 0.75-3 mg/kg; IP; 20 min before testing) decreased the number of cocaine responses in a dose-dependent manner during the first 15-min cocaine-free interval.
The bilateral infusion of CNQX disodium (0.5 or 1.25 μg) into the amygdala or dorsal hippocampus 10 min prior to a retention test partially blocks the expression of stepdown inhibitory avoidance in rats 24 h after training. CNQX disodium causes a complete blockade at a dose of 0.5 μg.
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Animal Model:
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Male Wistar rats weighing 180-200 g
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Dosage:
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0.75, 1.5, and 3 mg/kg
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Administration:
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IP; 20 min before testing
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Result:
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Decreased the number of cocaine (IV; 0.25 mg/infusion) responses in a dose-dependent manner during the first 15-min cocaine-free interval.
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6-CYANO-7-NITROQUINOXALINE-2;3-DIONE DISODIUM
上下游产品信息
上游原料
下游产品
6-CYANO-7-NITROQUINOXALINE-2;3-DIONE DISODIUM
生产厂家
479347-85-8, 6-CYANO-7-NITROQUINOXALINE-2;3-DIONE DISODIUM 相关搜索:
- 药靶配体
- CNQX二钠
- 7-硝基-2,3-二氧代-1,2,3,4-四氢喹喔啉-6-甲腈二钠盐
- CNQX二钠盐
- 479347-85-8
- 7-Nitro-2,3-dioxo-1,2,3,4-tetrahydroquinoxaline-6-carbonitrile, disodium salt
- 6-Cyano-7-nitroquinoxaline-2
- 3-dione disodium