LJI308
|
|
- CAS号:
- 1627709-94-7
- 英文名:
- LJI308
- 英文别名:
- LJI308;CS-2181;LJI 308;LJI308;LJI308 >=98% (HPLC);LJI-308;LJI 308;LJI308;2,6-Difluoro-4-[4-[4-(4-morpholinyl)phenyl]-3-pyridinyl]phenol;Phenol, 2,6-difluoro-4-[4-[4-(4-morpholinyl)phenyl]-3-pyridinyl]-;viability,Ribosomal S6 Kinase (RSK),LJI-308,stimulation,phosphorylation,LJI308,inhibit,mutation,Inhibitor,LJI 308,breaks,double-strand,cancer,S6K
- 中文名:
- LJI308
- 中文别名:
- 化合物LJI308;LJI308,RSK抑制剂;RSK抑制剂(LJI308);2,6-二氟-4-(4-吗啉苯基)吡啶-3-基)苯酚
- CBNumber:
- CB33060938
- 分子式:
- C21H18F2N2O2
- 分子量:
- 368.38
- MOL File:
- 1627709-94-7.mol
|
|
|
LJI308化学性质
-
储存条件:
-
Inert atmosphere,Store in freezer, under -20°C
-
|
-
溶解度:
-
Soluble in DMSO
-
|
-
形态:
-
crystalline solid
-
|
LJI308性质、用途与生产工艺
LJI308 是一种有效的泛 RSK 抑制剂,对 RSK1、RSK2 和 RSK3 的 IC50 分别为 6 nM、4 nM 和 13 nM。LJI308 抑制辐照、EGF 处理和 表达 KRAS 突变的细胞中 RSK (T359/S363) 和 YB-1 (S102) 的磷酸化。
LJI308 inhibits S6K1 with an IC
50
of 0.8 μM.
LJI308 inhibits YB-1 phosphorylation in CRC cells at concentrations of 5 to 25 μM. In a dose kinetics experiment, LJI308, starting at 2.5 μM, inhibits YB-1 phosphorylation in the KRAS mutated TNBC cell line MDA-MB-231 by approximately 86%. LJI308 effectively blocks RSK and YB-1 phosphorylation after EGF stimulation and after irradiation in KRAS wild-type HBL-100 cells.
LJI308 (1-10 μM; 96 hours) decreases cell viability by up to 90%.
Cell Viability Assay
Cell Line:
|
HTRY-LT cell lines
|
Concentration:
|
1-10 μM
|
Incubation Time:
|
96 hours
|
Result:
|
Decreased cell viability by up to 90%.
|
LJI308
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
---|
2024/01/25 | HY-19713 | LJI308 | | 1 mg | 409元 |
2024/01/25 | HY-19713 | LJI308 LJI308 | 1627709-94-7 | 5mg | 900元 |
1627709-94-7, LJI308 相关搜索:
- 细胞生物学试剂
- 抑制剂
- LJI308,RSK抑制剂
- 化合物LJI308
- 2,6-二氟-4-(4-吗啉苯基)吡啶-3-基)苯酚
- RSK抑制剂(LJI308)
- 1627709-94-7
- viability,Ribosomal S6 Kinase (RSK),LJI-308,stimulation,phosphorylation,LJI308,inhibit,mutation,Inhibitor,LJI 308,breaks,double-strand,cancer,S6K
- LJI308 >=98% (HPLC)
- Phenol, 2,6-difluoro-4-[4-[4-(4-morpholinyl)phenyl]-3-pyridinyl]-
- 2,6-Difluoro-4-[4-[4-(4-morpholinyl)phenyl]-3-pyridinyl]phenol
- CS-2181
- LJI-308;LJI 308;LJI308
- LJI 308;LJI308
- LJI308