GSK591 (EPZ-015866)
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- CAS号:
- 1616391-87-7
- 英文名:
- GSK591
- 英文别名:
- GSK591;GSK592;CS-2179;EPZ015866;GSK3203591;GSK-3203591;GSK 3203591;EPZ015866(GSK591);GSK-591(EPZ-15866);GSK591 (EPZ-015866)
- 中文名:
- GSK591 (EPZ-015866)
- 中文别名:
- 化合物GSK591;PRMT5抑制剂(GSK591);GSK591 (EPZ-015866)(新批次将出货);EPZ015866(GSK591),精氨酸甲基转移酶PRMT5 / MEP50复合物抑制剂;(S)-2-(环丁基氨基)-N-(3-(3,4-二氢异喹啉-2(1H)-基)-2-羟丙基)异烟酰胺
- CBNumber:
- CB33122823
- 分子式:
- C22H28N4O2
- 分子量:
- 380.48
- MOL File:
- 1616391-87-7.mol
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GSK591 (EPZ-015866)化学性质
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沸点:
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648.4±55.0 °C(Predicted)
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密度:
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1.252±0.06 g/cm3(Predicted)
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储存条件:
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2-8°C
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溶解度:
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≥38 mg/mL in DMSO; insoluble in H2O; ≥15.4 mg/mL in EtOH
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形态:
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powder
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酸度系数(pKa):
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13.54±0.46(Predicted)
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颜色:
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white to beige
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GSK591 (EPZ-015866)性质、用途与生产工艺
GSK591 (EPZ015866, GSK3203591)是一种有效的、选择性PRMT5抑制剂。
Target | Value |
PRMT5
(Cell-free assay)
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4 nM
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在体外生化实验中,GSK591通过甲基化H4,有效地抑制PRMT5/MEP50复合体,IC50为11 nM。 在Z-138细胞中,GSK591抑制SmD3的精氨酸对称甲基化,EC50为56 nM。
GSK591 (EPZ-015866)
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/08/19 | HY-100235 | GSK591 | | 1 mg | 502元 |
2024/08/19 | HY-100235 | GSK591 (EPZ-015866) GSK591 | 1616391-87-7 | 5mg | 1100元 |
1616391-87-7, GSK591 (EPZ-015866) 相关搜索:
- 生物试剂
- 合成有机化合物配体
- 原料药中间体
- 细胞生物学试剂
- 抑制剂
- EPZ015866(GSK591),精氨酸甲基转移酶PRMT5 / MEP50复合物抑制剂
- GSK591 (EPZ-015866)(新批次将出货)
- (S)-2-(环丁基氨基)-N-(3-(3,4-二氢异喹啉-2(1H)-基)-2-羟丙基)异烟酰胺
- 化合物GSK591
- PRMT5抑制剂(GSK591)
- 1616391-87-7
- GSK 591,EPZ-015866,GSK591,Inhibitor,GSK 3203591,EPZ 015866,inhibit,GSK-3203591,GSK-591,Histone Methyltransferase
- GSK-591(EPZ-15866)
- GSK592
- GSK591 >=97% (HPLC)
- 4-Pyridinecarboxamide, 2-(cyclobutylamino)-N-[(2S)-3-(3,4-dihydro-2(1H)-isoquinolinyl)-2-hydroxypropyl]-
- (S)-2-(cyclobutylamino)-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)isonicotinamide
- CS-2179
- EPZ-015866;EPZ 015866
- 2-(cyclobutylamino)-N-[(2S)-2-hydroxy-3-(1,2,3,4-tetrahydroisoquinolin-2-yl)propyl]pyridine-4-carboxamide
- 2-(Cyclobutylamino)-N-[(2S)-3-(3,4-dihydro-2(1H)-isoquinolinyl)-2-hydropropyl]-4-pyridinecarboxamide dihydrochloride
- GSK-3203591
- GSK3203591
- GSK 3203591
- EPZ-015866;EPZ 015866;GSK-591;GSK 591;GSK3203591;GSK-3203591;GSK 3203591
- GSK3203591(EPZ015866)
- GSK591
- EPZ015866,GSK3203591
- EPZ015866(GSK591)
- GSK591(EPZ015866,GSK3203591)
- EPZ015866
- GSK591 (EPZ-015866)