ADU-S100铵盐
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- CAS号:
- 1638750-96-5
- 英文名:
- ADU-S100 ammonium salt
- 英文别名:
- MIW815 ammonium salt;ADU-S100 ammonium salt;ML RR-S2 CDA (ammonium salt);STING-INDUCER-1 AMMONIUM SALT;ML RR-S2 CDA ammonium salt(ADU-S100);Adenosine, [P(R)]-5'-O-[(R)-hydroxymercaptophosphinyl]-P-thioadenylyl-(2'→5')-, cyclic nucleotide, ammonium salt (1:2);inhibit,ADU S100 ammonium salt,TMEM173,STING,MIW815,Inhibitor,MIW-815,Stimulator of Interferon Genes,MITA,MPYS,ERIS,ADU-S100,ML RR-S2 CDA,MIW 815,ADUS100 ammonium salt
- 中文名:
- ADU-S100铵盐
- 中文别名:
- ADU-S100铵盐;化合物 T10252L2;化合物ADU-S100 AMMONIUM SALT
- CBNumber:
- CB33155065
- 分子式:
- C20H27N11O10P2S2
- 分子量:
- 707.57
- MOL File:
- 1638750-96-5.mol
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ADU-S100铵盐化学性质
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储存条件:
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Store at -20°C
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溶解度:
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DMSO: 15 mg/ml; Water: 12.5 mg/ml
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形态:
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A solid
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ADU-S100铵盐性质、用途与生产工艺
ADU-S100 ammonium salt (MIW815 ammonium salt) 是干扰素基因刺激物的激活剂 (STING)，具有有效的抗肿瘤和免疫活性。
ADU-S100 shows enhanced type I IFN production over CDA in THP-1 human monocytes. In contrast, the dithio, mixed-linkage cyclic dinucleotide (CDN) derivatives (ML RR-CDA, ML RR-S2 CDG, and ML RR-S2 cGAMP) potently activate all five hSTING alleles, including the refractory hSTING
REF
and hSTING
Q
alleles. ADU-S100 induces the highest expression of IFN-β and the pro-inflammatory cytokines TNF-α, IL-6, and MCP-1 on a molar equivalent basis, as compared to endogenous ML cGAMP and the TLR3 agonist poly I:C. ADU-S100 is also found to induce aggregation of STING and induce phosphorylation of TBK1 and IRF3 in mouse bone marrow macrophage (BMM). ADU-S100 induces significantly higher levels of IFN-α when compared to ML cGAMP.
ADU-S100 shows higher anti-tumor control than the endogenous ML cGAMP. A dose response of the ADU-S100 compound is performed in B16 tumor-bearing mice, which identifies an optimal antitumor dose level that also elicites maximum tumor antigen-specific CD8
+
T cell responses, and improves long-term survival to 50%.
ADU-S100铵盐
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| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-12885B | ADU-S100铵盐
ADU-S100 ammonium salt | 1638750-96-5 | 1mg | 3300元 |
| 2023/03/20 | HY-12885B | ADU-S100铵盐
ADU-S100 ammonium salt | 1638750-96-5 | 5 mg | 12000元 |
1638750-96-5, ADU-S100铵盐 相关搜索:
- 活性分子
- 化合物ADU-S100 AMMONIUM SALT
- 化合物 T10252L2
- ADU-S100铵盐
- 1638750-96-5
- inhibit,ADU S100 ammonium salt,TMEM173,STING,MIW815,Inhibitor,MIW-815,Stimulator of Interferon Genes,MITA,MPYS,ERIS,ADU-S100,ML RR-S2 CDA,MIW 815,ADUS100 ammonium salt
- ADU-S100 ammonium salt
- STING-INDUCER-1 AMMONIUM SALT
- MIW815 ammonium salt
- ML RR-S2 CDA ammonium salt(ADU-S100)
- Adenosine, [P(R)]-5'-O-[(R)-hydroxymercaptophosphinyl]-P-thioadenylyl-(2'→5')-, cyclic nucleotide, ammonium salt (1:2)
- ML RR-S2 CDA (ammonium salt)