GET-73
|
|
|
- CAS号:
- 202402-01-5
- 英文名:
- GET-73
- 英文别名:
- GET-73;GET 73;GET-73;GET73;Gamma hydroxybutyric acid analogue;4-Methoxy-N-(4-(trifluoromethyl)benzyl)butanamide;Butanamide, 4-methoxy-N-[[4-(trifluoromethyl)phenyl]methyl]-;neuroprotective,anti-alcohol,inhibit,γ-hydroxybutyric acid,mGluR5,GHB,Inhibitor,GET73,GET-73,anxiolytic,glutamate
- 中文名:
- GET-73
- 中文别名:
- 化合物GET73;4-甲氧基-N-(4-(三氟甲基)苄基)丁酰胺
- CBNumber:
- CB33162603
- 分子式:
- C13H16F3NO2
- 分子量:
- 275.27
- MOL File:
- 202402-01-5.mol
|
|
|
GET-73化学性质
-
沸点:
-
394.7±42.0 °C(Predicted)
-
|
-
密度:
-
1.175±0.06 g/cm3(Predicted)
-
|
-
储存条件:
-
Sealed in dry,Room Temperature
-
|
-
溶解度:
-
DMSO : 100 mg/mL (363.28 mM; Need ultrasonic)
-
|
-
酸度系数(pKa):
-
15.11±0.46(Predicted)
-
|
GET-73性质、用途与生产工艺
GET73 是一种天然神经递质 γ-羟基丁酸 (GHB) 的类似物。GET73 具有抗酒精和抗焦虑的特性。GET73 对谷氨酸在海马的传递有显著的影响。
GET73 (1 µM, 10 µM; 1 hour) 1 hour before and during chronic ethanol exposure prevents ethanol-induced a reduction of cell viability, an alteration of cytoskeleton, a decrease in extracellular glutamate levels and an increase of reactive oxygen species production.
Cell Viability Assay
|
Cell Line:
|
Rat hippocampal neurons
|
|
Concentration:
|
0.1 µM, 1 µM, 10 µM
|
|
Incubation Time:
|
1 hour
|
|
Result:
|
Prevented the ethanol (75 mM, 4 days) -induced MTT reduction.
|
GET73 (5–50 mg/kg; i.g.) exerts an anxiolytic effect in Sprague-Dawley rats exposed to the elevated plus maze (EPM) test.
|
Animal Model:
|
Male SD rats (200-300 g and 300–350 g)
|
|
Dosage:
|
5 mg/kg, 10 mg/kg, 25 mg/kg, 50 mg/kg
|
|
Administration:
|
Oral gavage
|
|
Result:
|
Exerted an anxiolytic effect in rats exposed to the elevated plus maze (EPM) test.
|
GET-73
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-108034 | GET73 | | 1 mg | 1257元 |
| 2024/04/30 | HY-108034 | GET 73;GET-73;GET73
GET73 | 202402-01-5 | 5mg | 3300元 |
202402-01-5, GET-73 相关搜索:
- 药靶配体
- 化合物GET73
- 4-甲氧基-N-(4-(三氟甲基)苄基)丁酰胺
- 202402-01-5
- Butanamide, 4-methoxy-N-[[4-(trifluoromethyl)phenyl]methyl]-
- neuroprotective,anti-alcohol,inhibit,γ-hydroxybutyric acid,mGluR5,GHB,Inhibitor,GET73,GET-73,anxiolytic,glutamate
- 4-Methoxy-N-(4-(trifluoromethyl)benzyl)butanamide
- Gamma hydroxybutyric acid analogue
- GET 73;GET-73;GET73
- GET-73