T5601640
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- CAS号:
- 924473-59-6
- 英文名:
- T5601640
- 英文别名:
- T5601640;T56-LIMKi;T56-LIMKi - T5601640;T-5601640(T56-LIMKi);T5601640;T 5601640;T56-LIMKI;3-Methyl-N-(3-((3-(trifluoromethyl)phenyl)carbamoyl)phenyl)isoxazole-5-carboxamide;3-methyl-N-[3-[[3-(trifluoromethyl)phenyl]carbamoyl]phenyl]-1,2-oxazole-5-carboxamide;3-Methyl-N-[3-[[[3-(trifluoromethyl)phenyl]amino]carbonyl]phenyl]-5-isoxazolecarboxamide;5-Isoxazolecarboxamide, 3-methyl-N-[3-[[[3-(trifluoromethyl)phenyl]amino]carbonyl]phenyl]-;T-56-LIMKi,T56LIMKi,inhibit,T56-LIMKi,T 5601640,LIM Kinase (LIMK),LIMKs,T-5601640,Inhibitor,T56 LIMKi
- 中文名:
- T5601640
- 中文别名:
- T5601640游离态;化合物T56-LIMKI;T 5601640,LIMK2抑制剂;LIMK2抑制剂(T56-LIMKI);3-甲基-N-(3-((3-(三氟甲基)苯基)氨基甲酰基)苯基)异恶唑-5-甲酰胺
- CBNumber:
- CB33163675
- 分子式:
- C19H14F3N3O3
- 分子量:
- 389.33
- MOL File:
- 924473-59-6.mol
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T5601640化学性质
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沸点:
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403.4±45.0 °C(Predicted)
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密度:
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1.426±0.06 g/cm3(Predicted)
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储存条件:
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2-8°C
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溶解度:
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DMF: 30 mg/ml; DMF:PBS(pH7.2) (1:2): 0.33 mg/ml; DMSO: 20 mg/ml
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酸度系数(pKa):
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11.41±0.70(Predicted)
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形态:
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powder
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颜色:
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white to beige
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T5601640性质、用途与生产工艺
T56-LIMKi是LIM kinase 2 (LIMK2)抑制剂，抑制LIMK2介导的丝切蛋白磷酸化。
T56-LIMKi efficiently inhibits the growth of ST88-14, U87, Panc-1 cells, A549 lung cancer cells with IC
50
values of 18.3, 7.4, 35.2 and 90 μM, respectively. T56-LIMKi decreases phosphorylated cofilin (p-cofilin) levels and thus inhibits growth of several cancerous cell lines, including those of pancreatic cancer, glioma and schwannoma. It blocks the phosphorylation of cofilin which leads to actin severance and inhibition of tumor cell migration, tumor cell growth, and anchorage-independent colony formation in soft agar. T56-LIMKi (10-50 μM) reduces p-cofilin in a dose-dependent manner in NF1
−/−
MEFs with an IC
50
of 30 μM. Notably, the inhibitor does not affect the amounts of total cofil. 50μM T56-LIMKi causes a statistically significant reduction in the number of cells exhibiting stress fibers.
T56-LIMKi can induce inhibition of cofilin phosphorylation and Panc-1 tumor shrinkage
in vivo
. Mice treated with T56-LIMKi (60 mg/kg) shows a significant decrease in tumor volume compared to control.
T5601640
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上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-19352 | T5601640
T56-LIMKi | 924473-59-6 | 5mg | 650元 |
| 2024/01/25 | HY-19352 | T5601640
T56-LIMKi | 924473-59-6 | 10mM * 1mLin DMSO | 715元 |
924473-59-6, T5601640 相关搜索:
- 药靶配体
- 化工试剂
- 细胞生物学试剂
- T 5601640,LIMK2抑制剂
- 3-甲基-N-(3-((3-(三氟甲基)苯基)氨基甲酰基)苯基)异恶唑-5-甲酰胺
- LIMK2抑制剂(T56-LIMKI)
- 化合物T56-LIMKI
- T5601640游离态
- 924473-59-6
- T-56-LIMKi,T56LIMKi,inhibit,T56-LIMKi,T 5601640,LIM Kinase (LIMK),LIMKs,T-5601640,Inhibitor,T56 LIMKi
- 3-Methyl-N-(3-((3-(trifluoromethyl)phenyl)carbamoyl)phenyl)isoxazole-5-carboxamide
- 3-methyl-N-[3-[[3-(trifluoromethyl)phenyl]carbamoyl]phenyl]-1,2-oxazole-5-carboxamide
- T-5601640(T56-LIMKi)
- 3-Methyl-N-[3-[[[3-(trifluoromethyl)phenyl]amino]carbonyl]phenyl]-5-isoxazolecarboxamide
- T5601640;T 5601640;T56-LIMKI
- T56-LIMKi - T5601640
- 5-Isoxazolecarboxamide, 3-methyl-N-[3-[[[3-(trifluoromethyl)phenyl]amino]carbonyl]phenyl]-
- T56-LIMKi
- T5601640