607736-84-5
|
|
|
- CAS号:
- 607736-84-5
- 英文名:
- SUN 1334H
- 英文别名:
- SUN 1334H;2-?[[(2E)?-?4-?[4-?[bis(4-?Fluorophenyl)?methyl]?-?1-?piperazinyl]?-?2-?buten-?1-?yl]?oxy]?-acetic acid hydrochloride
- 中文名:
- 607736-84-5
- 中文别名:
- 化合物 T13040;化合物 SUN 1334H
- CBNumber:
- CB33175591
- 分子式:
- C23H27ClF2N2O3
- 分子量:
- 452.93
- MOL File:
- 607736-84-5.mol
|
|
|
607736-84-5化学性质
-
储存条件:
-
Store at -20°C
-
|
-
溶解度:
-
Soluble in DMSO
-
|
-
形态:
-
Solid
-
|
-
颜色:
-
Light yellow to yellow
-
|
607736-84-5性质、用途与生产工艺
SUN 1334H 是一种有效的，可口服的，选择性的 H1 receptor 拮抗剂，Ki 值为 9.7 nM。
SUN-1334H causes potent inhibition of histamine induced contractions of isolated guinea-pig ileum with an IC
50
(half the maximal inhibitory concentration) of 0.198 μM. In CHO-K1/hERG cells, SUN-1334H does not modulate hERG K
+
-currents at concentrations as high as 100 μM. SUN-1334H, cetirizine and hydroxyzine cause comparable inhibition of NLF leukocytes, IL-4 and total protein concentrations.
SUN-1334H potently inhibits histamine-induced bronchospasm over 24 hours following oral administration and completely suppresses histamine-induced skin wheal in beagle dogs and ovalbumin-induced rhinitis in guinea pigs. In skin allergy models, SUN-1334H shows potent reduction of passive and active cutaneous anaphylactic reactions. In central nervous system side effects models, SUN-1334H, desloratadine and fexofenadine are devoid of any significant effects.
607736-84-5
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2025/05/22 | HY-U00084 | 607736-84-5
SUN 1334H | 607736-84-5 | 1mg | 1000元 |
607736-84-5, 607736-84-5 相关搜索:
- 抑制剂
- 化合物 SUN 1334H
- 化合物 T13040
- 607736-84-5
- 2-?[[(2E)?-?4-?[4-?[bis(4-?Fluorophenyl)?methyl]?-?1-?piperazinyl]?-?2-?buten-?1-?yl]?oxy]?-acetic acid hydrochloride
- SUN 1334H