102271-49-8
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- CAS号:
- 102271-49-8
- 英文名:
- 2(3H)-Furanone, 3-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]dihydro-, (E)-
- 英文别名:
- PGS-IN-1;α-(3,5-di-tert-butyl-4-hydroxybenzylidene)-γ-butyrolactone;2(3H)-Furanone, 3-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]dihydro-, (E)-;2(3H)-Furanone, 3-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]dihydro-, (E)- (9CI);KME 4,inhibit,PGSIN1,KME4,Lipoxygenase,Inhibitor,Prostaglandin E synthase,PGE synthase,LOX,PGS IN 1
- 中文名:
- 102271-49-8
- 中文别名:
- 化合物PGS-IN-1
- CBNumber:
- CB33339560
- 分子式:
- C19H26O3
- 分子量:
- 302.41
- MOL File:
- 102271-49-8.mol
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102271-49-8化学性质
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沸点:
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429.1±45.0 °C(Predicted)
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密度:
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1.096±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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酸度系数(pKa):
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11.51±0.50(Predicted)
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102271-49-8性质、用途与生产工艺
PGS-IN-1是有效的前列腺素合成酶 (prostaglandin synthetase) 抑制剂，IC50 值为0.28 μM；也可抑制5-脂肪氧合酶 (5-lipoxygenase) 的活性，IC50 值为 1.05 μM。
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5-Lipoxygenase
1.05 μM (IC
50
)
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The synthesized α-benzulidene-γ-butyrolactones are pure isomers (either
cis
or
trans
). PGS-IN-1 is the
trans
isomer. PGS-IN-1 exhibits potent antiinflammatrory and PGS inhibitory activity (IC
50
=0.28 μM). PGS-IN-1 also shows potent inhibitory activity against 5-lipoxygenase (IC
50
=1.05 μM).
102271-49-8
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-101587 | 102271-49-8
PGS-IN-1 | 102271-49-8 | 1mg | 2000元 |
| 2024/01/25 | HY-101587 | 102271-49-8
PGS-IN-1 | 102271-49-8 | 5mg | 4000元 |
102271-49-8, 102271-49-8 相关搜索:
- 化合物PGS-IN-1
- 102271-49-8
- KME 4,inhibit,PGSIN1,KME4,Lipoxygenase,Inhibitor,Prostaglandin E synthase,PGE synthase,LOX,PGS IN 1
- 2(3H)-Furanone, 3-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]dihydro-, (E)- (9CI)
- α-(3,5-di-tert-butyl-4-hydroxybenzylidene)-γ-butyrolactone
- PGS-IN-1
- 2(3H)-Furanone, 3-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]dihydro-, (E)-