175212-04-1
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- CAS号:
- 175212-04-1
- 英文名:
- CMI977
- 英文别名:
- LDP977;CMI977;CMI977 (LDP977);1-[4-[(2S,5S)-5-[(4-fluorophenoxy)methyl]oxolan-2-yl]but-3-ynyl]-1-hydroxyurea;Urea, N-[4-[(2S,5S)-5-[(4-fluorophenoxy)methyl]tetrahydro-2-furanyl]-3-butyn-1-yl]-N-hydroxy-
- 中文名:
- 175212-04-1
- 中文别名:
- 化合物 T14986;CMI977 (LDP977)
- CBNumber:
- CB33339641
- 分子式:
- C16H19FN2O4
- 分子量:
- 322.33
- MOL File:
- 175212-04-1.mol
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175212-04-1化学性质
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熔点:
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106-107 °C
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沸点:
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524.8±60.0 °C(Predicted)
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密度:
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1.33±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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酸度系数(pKa):
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10.12±0.50(Predicted)
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175212-04-1性质、用途与生产工艺
CMI977 是一种有效的 5-Lipoxygenase (5-LO) 抑制剂。
CMI977 is a potent 5-lipoxygenase (5-LO) inhibitor that intervenes in the production of leukotrienes and is presently being developed for the treatment of chronic asthma. It is a single enantiomer with an all-trans (2S,5S) configuration. Of the four isomers of CMI977, the S,S isomer is found to have the best biological activity and is selected for further development.
175212-04-1
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175212-04-1, 175212-04-1 相关搜索:
- 抑制剂
- CMI977 (LDP977)
- 化合物 T14986
- 175212-04-1
- CMI977 (LDP977)
- 1-[4-[(2S,5S)-5-[(4-fluorophenoxy)methyl]oxolan-2-yl]but-3-ynyl]-1-hydroxyurea
- Urea, N-[4-[(2S,5S)-5-[(4-fluorophenoxy)methyl]tetrahydro-2-furanyl]-3-butyn-1-yl]-N-hydroxy-
- LDP977
- CMI977