达尔卓潘
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- CAS号:
- 79094-20-5
- 英文名:
- Daltroban
- 英文别名:
- BM-13505;DALTROBAN;SKF-96148;Daltroban USP/EP/BP;DatelliptiumChloride;Daltroban >98% (HPLC);4-[2-(4-Chlorobenzene-sulfonamido)ethyl]benzeneacetic acid;4-[2-[(4-CHLOROPHENYLSULFONYL)AMINO]ETHYL]BENZENEACETIC ACID;2-[4-[2-(4-chlorophenyl)sulfonylaminoethyl]phenyl]acetic acid;4-[2-[(4-Chlorophenylsulfonyl)amino]ethyl]benzeneacetic acid, BM-13505, SKF-96148
- 中文名:
- 达尔卓潘
- 中文别名:
- 达曲班;达替氯铵;达尔卓潘;化合物 T15049;达曲班 (达尔卓潘);4-[2-(4-氯苯磺酰氨基)乙基]苯乙酸;2-[4-[2-(4-氯苯基)磺酰胺基乙基]苯基]乙酸;2-[2-(二乙氨基)乙基]-9-羟基-5,11-二甲基-6H-吡啶并[4,3-B]咔唑
- CBNumber:
- CB3384707
- 分子式:
- C16H16ClNO4S
- 分子量:
- 353.82
- MOL File:
- 79094-20-5.mol
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达尔卓潘化学性质
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熔点:
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132.5-137.4 °C(lit.)
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沸点:
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555.3±60.0 °C(Predicted)
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密度:
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1.378±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO: 22 mg/mL, soluble
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形态:
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A solid
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酸度系数(pKa):
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4.33±0.10(Predicted)
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颜色:
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white
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InChI:
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InChI=1S/C16H16ClNO4S/c17-14-5-7-15(8-6-14)23(21,22)18-10-9-12-1-3-13(4-2-12)11-16(19)20/h1-8,18H,9-11H2,(H,19,20)
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InChIKey:
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IULOBWFWYDMECP-UHFFFAOYSA-N
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SMILES:
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C1(CC(O)=O)=CC=C(CCNS(C2=CC=C(Cl)C=C2)(=O)=O)C=C1
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CAS 数据库:
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79094-20-5(CAS DataBase Reference)
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达尔卓潘性质、用途与生产工艺
Daltroban (BM-13505) 是一种选择性和特异性血栓素 A2 (TXA2) 受体拮抗剂。Daltroban 增加血管平滑肌细胞内钙。Daltroban 对再灌注损伤有保护作用。
Daltroban (BM-13505) (1 mg/kg; i.v.; per hour) exerts protective effect in reperfusion injury following acute myocardial ischemia in cats.
In comparison with vehicle (physiological saline)-treated cats, Daltroban (20 mg/kg per hour i.v.) reduces the ischaemia-induced rise in the ST segment and prevented the development of a Q-wave in the ECG during reperfusion. Daltroban protects the myocardium from ischaemic injury and that this effect involves prevention of ischaemia-induced leukocytosis.
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Animal Model:
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Adult male cats (2.8 to 4.6 kg; anesthetized cat model)
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Dosage:
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1 mg/kg
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Administration:
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i.v.; 30 minutes before reperfusion at a rate of 1 mg/kg followed by 1 mg/kg/hour
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Result:
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Significantly reduced the area of ischemic tissue as a percent of total left ventricular mass and total area at risk, without altering basic hemodynamics and thereby not influencing myocardial oxygen demand.
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化学性质
从含水乙醇得白色结晶，熔点138～140℃。
用途
为血栓素A2受体的特异性强效拮抗剂，有抑制血小板聚集，影响血栓形成，防止猝死等作用。用于治疗心肌缺血、出血性休克、内毒性休克、心肺性猝死、急性肾衰竭、动脉粥样硬化等。
生产方法
4-氰甲基苯乙酸溶于无水乙醇，加入氯化钯和浓盐酸，在室温和0.5MPa通氢。滤除催化剂，滤液减压蒸出溶剂。加入水，充分溶解，过滤，滤液为化合物(I)的溶液。往该溶液中，加入碳酸钾，再在80℃加入对氯苯磺酰氯。加毕，在80℃搅拌。冷却，用2mol/L盐酸酸化至Ph值2。滤集固体，水洗，干燥。再用66%乙醇重结晶，得达曲班，熔点138～140℃。
达尔卓潘
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-121018 | 达尔卓潘
Daltroban | 79094-20-5 | 1mg | 2000元 |
| 2024/01/25 | HY-U00337 | 达尔卓潘
Datelliptium chloride | 79094-20-5 | 1mg | 6800元 |
达尔卓潘
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达尔卓潘国内生产厂家
79094-20-5, 达尔卓潘 相关搜索:
- 药物
- 血液系统用药
- Chromatography
- Drug Standards
- Forensic and Veterinary Standards
- Analytical Standards
- Analytical Chromatography Product Catalog
- C16H16ClNO4S
- 2-[2-(二乙氨基)乙基]-9-羟基-5,11-二甲基-6H-吡啶并[4,3-B]咔唑
- 化合物 T15049
- 达尔卓潘
- 达曲班 (达尔卓潘)
- 2-[4-[2-(4-氯苯基)磺酰胺基乙基]苯基]乙酸
- 达替氯铵
- 4-[2-(4-氯苯磺酰氨基)乙基]苯乙酸
- 达曲班
- 79094-20-5
- Daltroban USP/EP/BP
- Daltroban >98% (HPLC)
- 4-[2-(4-Chlorobenzene-sulfonamido)ethyl]benzeneacetic acid
- 4-[2-[(4-Chlorophenylsulfonyl)amino]ethyl]benzeneacetic acid, BM-13505, SKF-96148
- DatelliptiumChloride
- DALTROBAN
- BM-13505
- 4-[2-[(4-CHLOROPHENYLSULFONYL)AMINO]ETHYL]BENZENEACETIC ACID
- 2-[4-[2-(4-chlorophenyl)sulfonylaminoethyl]phenyl]acetic acid
- SKF-96148