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8-(4-CHLOROPHENYLTHIO)ADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT

生物活性 靶点 体外研究

, 129735-01-9, 结构式
CAS号:
129735-01-9
英文名:
8-(4-CHLOROPHENYLTHIO)ADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT
英文别名:
RP-8-CPT-CAMPS;RP-8-CPT-CAMPS SODIUM SALT;8-(4-CHLOROPHENYLTHIO)ADENOSINE-*3',5-CYCLIC MONOPH;8-(4-CHLOROPHENYLTHIO)ADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER;Adenosine, 8-[(4-chlorophenyl)thio]-, cyclic 3',5'-[hydrogen [P(R)]-phosphorothioate];8-(4-CHLOROPHENYLTHIO)ADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT;8-(4-chlorophenylthio)adenosine-3’,5’-cyclicmonophosphorothioate,spisomer(sp-8-cpt-camps),sodi
中文名:
中文别名:
CBNumber:
CB3431184
分子式:
C16H15ClN5O5PS2
分子量:
487.88
MOL File:
129735-01-9.mol

8-(4-CHLOROPHENYLTHIO)ADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT化学性质

储存条件:
−20°C
形态:
solid
安全信息
WGK Germany: 3

8-(4-CHLOROPHENYLTHIO)ADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT性质、用途与生产工艺

生物活性

Rp-8-CPT-cAMPS，一种 cAMP 类似物，是 cAMP 诱导的依赖 cAMP 的 PKA I 和 PKA II 活化的有效和竞争性的拮抗剂。Rp-8-CPT-cAMPS 优先选择 RI 的位点 A 与 RII 的位点 B。

靶点

PKA

体外研究

Rp-8-CPT-cAMPS (100 μM; 15 min) blocks phosphorylation of VASP by 6-Bnz-cAMP and largely reduces VASP phosphorylation by forskolin and fenoterol.
Rp-8-CPT-cAMPS (100 μM; 30 min) reduces GTP-loading of Rap1 by both 8-pCPT-2'-O-Me-cAMP and 6-Bnz-cAMP.
Rp-8-CPT-cAMPS (100 μM; 30 min) largely diminishes the augmentation of bradykinin-induced IL-8 release by the PKA activator 6-Bnz-cAMP and the Epac activator 8-pCPT-2'-O-Me-cAMP.
Rp-8-CPT-cAMPS (10 μM) inhibits the endothelium-dependent and -independent relaxation which induced by Venom in pre-contracted rat mesenteric artery rings.

8-(4-CHLOROPHENYLTHIO)ADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT 上下游产品信息

上游原料

下游产品

8-(4-CHLOROPHENYLTHIO)ADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT 生产厂家

全球有 9家供应商   8-(4-CHLOROPHENYLTHIO)ADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT国内生产厂家
供应商联系电话电子邮件国家产品数优势度
BOC Sciences +16314854226 inquiry@bocsci.com 美国 19743 58
BOC Sciences 16314854226 inquiry@bocsci.com 美国 9713 58
天津普西唐生物医药科技有限公司 010-60605840 15801484223 psaitong@jm-bio.com 中国 29834 58
Aladdin Scientific Corporation +1-833-552-7181 sales@aladdinsci.com 美国 52927 58
 

129735-01-9, 8-(4-CHLOROPHENYLTHIO)ADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT 相关搜索:

  • BioChemical
  • Cell Biology
  • Cell Signaling and Neuroscience
  • Cyclic Nucleotide Metabolism
  • Cyclic Nucleotides and Analogs
  • G Proteins and Cyclic Nucleotides
  • C16H15ClN5O5PS2
  • C16H14ClN5O5PS2Na
  • 129735-01-9
  • Adenosine, 8-[(4-chlorophenyl)thio]-, cyclic 3',5'-[hydrogen [P(R)]-phosphorothioate]
  • 8-(4-CHLOROPHENYLTHIO)ADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT
  • 8-(4-CHLOROPHENYLTHIO)ADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER
  • 8-(4-chlorophenylthio)adenosine-3’,5’-cyclicmonophosphorothioate,spisomer(sp-8-cpt-camps),sodi
  • RP-8-CPT-CAMPS SODIUM SALT
  • RP-8-CPT-CAMPS
  • 8-(4-CHLOROPHENYLTHIO)ADENOSINE-*3',5-CYCLIC MONOPH
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