TP0463518
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- CAS号:
- 1558021-37-6
- 英文名:
- TP0463518
- 英文别名:
- BGE-117;TP0463518;HIF-PH,TP 0463518,TP0463518,TP-0463518,HIFs,inhibit,Inhibitor,HIF/HIF Prolyl-Hydroxylase,Hypoxia-inducible factors;Glycine, N-[[1-[[6-(4-chlorophenoxy)-3-pyridinyl]methyl]-1,2,5,6-tetrahydro-4-hydroxy-2-oxo-3-pyridinyl]carbonyl]-;2-(1-((6-(4-Chlorophenoxy)pyridin-3-yl)methyl)-4-hydroxy-2-oxo-1,2,5,6-tetrahydropyridine-3-carboxamido)acetic acid
- 中文名:
- TP0463518
- 中文别名:
- 化合物TP0463518
- CBNumber:
- CB34656567
- 分子式:
- C20H18ClN3O6
- 分子量:
- 431.83
- MOL File:
- 1558021-37-6.mol
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TP0463518化学性质
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沸点:
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775.8±60.0 °C(Predicted)
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密度:
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1.512±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO:40.0(Max Conc. mg/mL);92.63(Max Conc. mM)
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形态:
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A solid
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酸度系数(pKa):
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3.63±0.10(Predicted)
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TP0463518性质、用途与生产工艺
TP0463518 是一种有效的 hypoxia-inducible factor prolyl hydroxylases (PHDs) 的抑制剂,对人PHD2的Ki值为5.3 nM。TP0463518 还可抑制人PHD1、人PHD3和猴PHD2,对应的IC50值分别为18 nM,63 nM和22 nM。
Target | Value |
hPHD2
(Cell-free assay)
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5.3 nM(Ki)
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hPHD1
(Cell-free assay)
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18 nM
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monkey PHD2
(Cell-free assay)
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22 nM
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hPHD3
(Cell-free assay)
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63 nM
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TP0463518
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/04/30 | HY-112144 | TP0463518 TP0463518 | 1558021-37-6 | 5mg | 1800元 |
2024/04/30 | HY-112144 | TP0463518 TP0463518 | 1558021-37-6 | 10mM * 1mLin DMSO | 1980元 |
1558021-37-6, TP0463518 相关搜索:
- 药靶配体
- 对照品
- 1558021-37-0
- 化合物TP0463518
- 1558021-37-6
- 2-(1-((6-(4-Chlorophenoxy)pyridin-3-yl)methyl)-4-hydroxy-2-oxo-1,2,5,6-tetrahydropyridine-3-carboxamido)acetic acid
- HIF-PH,TP 0463518,TP0463518,TP-0463518,HIFs,inhibit,Inhibitor,HIF/HIF Prolyl-Hydroxylase,Hypoxia-inducible factors
- BGE-117
- Glycine, N-[[1-[[6-(4-chlorophenoxy)-3-pyridinyl]methyl]-1,2,5,6-tetrahydro-4-hydroxy-2-oxo-3-pyridinyl]carbonyl]-
- TP0463518