NKH477
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- CAS号:
- 138605-00-2
- 英文名:
- N,N-DIMETHYL-(3R,4AR,5S,6AS,10S,10AR,10BS)-5-(ACETYLOXY)-3-ETHENYLDODECAHYDRO-10,10B-DIHYDROXY-3,4A,7,7,10A-PENTAMETHYL-1-OXO-1H-NAPHTHO[2,1-B]PYRAN-6-YL ESTER B-ALANINE HYDROCHLORIDE
- 英文别名:
- Adehl;NKH 477;MKH 477;Adehl (TN);Forskolin, NKH477;Colforsin dapropate;NKH477 (hydrochloride);VIRRLEDAYYYTOD-YHEOSNBFSA-N;colforsindapropatehydrochloride;colforsin daropate hydrochloride
- 中文名:
- NKH477
- 中文别名:
- CBNumber:
- CB3477436
- 分子式:
- C27H44ClNO8
- 分子量:
- 546.1
- MOL File:
- 138605-00-2.mol
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NKH477化学性质
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储存条件:
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2-8°C
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溶解度:
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H2O: soluble3mg/mL, clear to slightly hazy (warmed)
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形态:
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White solid
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颜色:
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white to beige
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水溶解性:
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Soluble to 40 mM in water
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NKH477性质、用途与生产工艺
NKH477 (Colforsin dapropate hydrochloride) 是一种新型水溶性毛喉素衍生物，主要通过对舒张性心脏功能的有益作用来改善心力衰竭。 NKH477 直接激活腺苷酸环化酶 (adenylate cyclase) 的催化单元并增加细胞内 cAMP。 NKH477 在体内抗增殖作用，可以抑制大鼠原位肺同种异体移植物的急性排斥。
NKH477 (Colforsin dapropate hydrochloride) (orally; 1-3 mg/kg/day; days 3 and 5) prolonged lung allograft survival in a dose dependent manner.
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Animal Model:
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Specific-pathogen-free inbred male Lewis rats (LEW) weighing 250 to 280 g
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Dosage:
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1, 2 or 3 mg/kg/day
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Administration:
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Orally; daily; Days 3 and 5
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Result:
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Prolonged lung allograft survival in a dose dependent manner.
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NKH477
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下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/08/19 | HY-103193 | NKH477
NKH477 | 138605-00-2 | 5mg | 1000元 |
| 2024/08/19 | HY-103193 | NKH477
NKH477 | 138605-00-2 | 10mg | 1800元 |
138605-00-2, NKH477 相关搜索:
- Cyclic Nucleotide related
- Signalling
- C27H44ClNO8
- C27H43NO8HCl
- 138605-00-2
- VIRRLEDAYYYTOD-YHEOSNBFSA-N
- Colforsin dapropate
- Forskolin, NKH477 - CAS 138605-00-2 - Calbiochem
- N,N-DIMETHYL-(3R,4AR,5S,6AS,10S,10AR,10BS)-5-(ACETYLOXY)-3-ETHENYLDODECAHYDRO-10,10B-DIHYDROXY-3,4A,7,7,10A-PENTAMETHYL-1-OXO-1H-NAPHTHO[2,1-B]PYRAN-6-YL ESTER B-ALANINE HYDROCHLORIDE
- MKH 477
- β-Alanine, N,N-dimethyl-, 5-(acetyloxy)-3-ethenyldodecahydro-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-1H-naphtho[2,1-b]pyran-6-yl ester, hydrochloride, [3R-(3α,4aβ,5β,6β,6aα,10α,10aβ,10bα)]-
- β-Alanine, N,N-dimethyl-, (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-(acetyloxy)-3-ethenyldodecahydro-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-1H-naphtho[2,1-b]pyran-6-yl ester, hydrochloride
- colforsin daropate hydrochloride
- Adehl
- 6-(3-Dimethylaminopropionyl)forskolin hydrochloride
- 1H-Naphtho[2,1-b]pyran, β-alanine deriv.
- Adehl (TN)
- N,N-Dimethyl-(3R,4aR,5S,6aS,10S,10aR,10bS)-5-(acetyloxy)-3-ethenyldodecahydro-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-
- y-3,4a,7,7,10a-pentamethyl-1-oxo-1h-naphtho(2,1-b)pyran-6-ylester,hydrochlor
- 6-[3-(dimethylamino)propionyl]-forskolin
- NKH477 (hydrochloride)
- N,N-Dimethyl-(3R,4aR,5S,6aS,10S,10aR,10bS)-5-(acetyloxy)-3-ethenyldodecahydro-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-1H-naphtho[2,1-b]pyran-6-ylesterβ-alaninehydrochloride
- N,N-Dimethyl-(3R,4aR,5S,6aS,10S,10aR,10bS)-5-(acetyloxy)-3-ethenyldodecahydro-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-1H-naphtho[2,1-b]pyran-6-yl ester beta-alanine hydrochloride
- colforsindapropatehydrochloride
- beta-alanine,n,n-dimethyl-,5-(acetyloxy)-3-ethenyldodecahydro-10,10b-dihydrox
- Forskolin, NKH477
- N,N-dimethyl-, (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-(acetyloxy)-3-ethenyldodecahydro-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-1H-naphtho[2,1-b]pyran-6-yl ester b-Alanine hydrochloride
- (3r-(3-alpha,4a-beta,5-beta,6-beta,6a-alpha,10-alpha,10a-beta,10b-alpha))-id
- NKH 477
- N,N-DIMETHYL-(3R,4AR,5S,6AS,10S,10AR,10BS)-5-(ACETYLOXY)-3-ETHENYLDODECAHYDRO-10,10B-DIHYDROXY-3,4A,7,7,10A-PENTAMETHYL-1-OXO-1H-NAPHTHO[2,1-B]PYRAN-6-YL ESTER B-ALANINE HYDROCHLORIDE