2173232-79-4
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- CAS号:
- 2173232-79-4
- 英文名:
- LOM612
- 英文别名:
- LOM612;LOM-612,LOM612;Naphth[2,3-d]isothiazole-4,9-dione, 3-(dimethylamino)-
- 中文名:
- 2173232-79-4
- 中文别名:
- 化合物 T19405
- CBNumber:
- CB34797080
- 分子式:
- C13H10N2O2S
- 分子量:
- 258.3
- MOL File:
- 2173232-79-4.mol
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2173232-79-4化学性质
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沸点:
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386.2±42.0 °C(Predicted)
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密度:
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1.436±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO : 6 mg/mL (23.23 mM);Water : < 0.1 mg/mL (insoluble)
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酸度系数(pKa):
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3.04±0.20(Predicted)
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2173232-79-4性质、用途与生产工艺
LOM612 有效对 FOXO 胞质-胞核穿梭进行定位，在 U2fox RELOC 细胞中 EC50 值为 1.5 μM。
EC50: 1.5 μM (FOXO, in U2fox RELOC cells)
LOM612 potently activates nuclear translocation of FOXO with an EC
50
value of 1.5 μM, and this effect is independent of CRM-1. LOM612 effectively induces translocation of endogenous FOXO3a and FOXO1, and increases the expression of the FOXO target genes p27 and FasL. LOM612 shows no effect on the nuclear export of endogenous NFKB2 transcription factor in U2OS cells. LOM612 is cytotoxic to HepG2 cells, with an IC
50
value of 0.64 μM, and does not sensitize non-cancer THLE2 cells (IC
50
, 2.76 μM).
2173232-79-4
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-101035 | LOM612 | | 1 mg | 1590元 |
| 2024/01/25 | HY-101035 | 2173232-79-4
LOM612 | 2173232-79-4 | 5mg | 3500元 |
2173232-79-4, 2173232-79-4 相关搜索:
- 化合物 T19405
- 2173232-79-4
- LOM-612,LOM612
- Naphth[2,3-d]isothiazole-4,9-dione, 3-(dimethylamino)-
- LOM612