INH14
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- CAS号:
- 200134-22-1
- 英文名:
- 1-(4-ethylphenyl)-3-phenylurea
- 英文别名:
- INH14;1-(4-ethylphenyl)-3-phenylurea;N-(4-Ethylphenyl)-N'-phenylurea;Urea, N-(4-ethylphenyl)-N'-phenyl-;INH14,inhibit,IKK,INH 14,IκB kinase,I kappa B kinase,INH-14,Inhibitor
- 中文名:
- INH14
- 中文别名:
- 化合物INH14;1-(4-乙基苯基)-3-苯基脲
- CBNumber:
- CB34812646
- 分子式:
- C15H16N2O
- 分子量:
- 240.3
- MOL File:
- 200134-22-1.mol
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INH14化学性质
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沸点:
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296.4±19.0 °C(Predicted)
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密度:
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1.185±0.06 g/cm3(Predicted)
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储存条件:
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Sealed in dry,Room Temperature
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溶解度:
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DMSO:86.5(Max Conc. mg/mL);359.96(Max Conc. mM)
Ethanol:18.0(Max Conc. mg/mL);74.9(Max Conc. mM)-
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酸度系数(pKa):
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14.46±0.70(Predicted)
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INH14性质、用途与生产工艺
INH14是TLR2介导的NF-kB激活抑制剂，对IKKα和IKKβ的IC50值分别为8.975 μM和3.598 μM。
| Target | Value |
NF-κB
()
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IKKβ
()
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3.598 μM
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IKKα
()
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8.975 μM
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INH14 (5 µg/g, i.p. for 2 hours) reduces lipopeptide-induced inflammation in mice.
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Animal Model:
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8-week old, male, pathogen-free C57BL/6J mice
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Dosage:
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5 µg/g, one hour before Pam2CSK4 injection
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Administration:
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I.P. for 2 hours
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Result:
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Decreased TNFα production in mice.
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INH14
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-114454 | INH14 | | 1 mg | 454元 |
| 2024/01/25 | HY-114454 | INH14
INH14 | 200134-22-1 | 5mg | 1000元 |
200134-22-1, INH14 相关搜索:
- 药靶配体
- 1-(4-乙基苯基)-3-苯基脲
- 化合物INH14
- 200134-22-1
- INH14,inhibit,IKK,INH 14,IκB kinase,I kappa B kinase,INH-14,Inhibitor
- N-(4-Ethylphenyl)-N'-phenylurea
- Urea, N-(4-ethylphenyl)-N'-phenyl-
- INH14
- 1-(4-ethylphenyl)-3-phenylurea