396073-89-5
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- CAS号:
- 396073-89-5
- 英文名:
- BN82002 HYDROCHLORIDE SALT
- 英文别名:
- BN 82002;BN-82002;BN82002 hydrochloride;CDC25 Phosphatase Inhibitor I;CDC25 Phosphatase Inhibitor I, BN82002;CDC25 Phosphatase Inhibitor I, BN82002 - CAS 396073-89-5 - Calbiochem;Phenol, 4-(dimethylamino)-2-methoxy-6-[[methyl[2-(4-nitrophenyl)ethyl]amino]methyl]-;CDC25C,BN82002,CDC25A,BN-82002,inhibit,CDC25B3,MIA PaCa-2,Inhibitor,CDC25B2,BN 82002,Phosphatase
- 中文名:
- 396073-89-5
- 中文别名:
- 化合物CDC25 PHOSPHATASE INHIBITOR I;4-(二甲基氨基)-2-甲氧基-6-[[甲基[2-(4-硝基苯基)乙基]氨基]甲基]苯酚
- CBNumber:
- CB3503173
- 分子式:
- C19H25N3O4
- 分子量:
- 359.42
- MOL File:
- 396073-89-5.mol
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396073-89-5化学性质
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熔点:
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92-93 °C
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沸点:
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532.6±50.0 °C(Predicted)
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密度:
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1.216±0.06 g/cm3(Predicted)
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储存条件:
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2-8°C
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溶解度:
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DMSO: 10 mg/mL
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形态:
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solid
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酸度系数(pKa):
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10.07±0.48(Predicted)
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颜色:
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tan
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396073-89-5性质、用途与生产工艺
BN82002 是 CDC25 phosphatase 家族的有效，选择性和不可逆的泛抑制剂。 BN82002 抑制 CDC25A，CDC25B2，CDC25B3，CDC25C CDC25A 和 25C-cat 的 IC50 值分别为 2.4、3.9、6.3、5.4 和 4.6 µM。 BN82002 显示出比 CD45 酪氨酸磷酸酶高约 20 倍的选择性。
IC50: 2.4 μM (CDC25A), 3.9 μM (CDC25B2), 6.3 μM (CDC25B3), 5.4 μM (CDC25C), 4.6 μM (CDC25C-cat).
The effect of BN82002 on cell proliferation is evaluated in vitro on several human tumor cell lines. Menadione, which has been reported to inhibit cell proliferation, is used as a control. All of the examined cell lines are sensitive to BN82002 and Menadione in a concentration-dependent manner in the low micromolar range. The most sensitive is the pancreatic cancer cell line MIA PaCa-2 with an IC
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of 7.2 μM, and the less sensitive cell line is the colon cancer HT-29 with an IC
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of 32.6 μM. The range of activity is very similar to the one observed with menadione (5-15 μM). It is also showed that 50 μM BN82002 is a concentration that fully inhibits cell proliferation, the cell cycle distribution is only modestly affected with a slight decrease in S phase and an increase in cells containing both a G1 and a G2 DNA content, suggesting that the cells treated with BN82002 are arrested at various stages of the cell cycle.
396073-89-5
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-112776A | BN82002 hydrochloride | | 1 mg | 500元 |
| 2024/01/25 | HY-112776A | 396073-89-5
BN82002 hydrochloride | 396073-89-5 | 5 mg | 1100元 |
396073-89-5, 396073-89-5 相关搜索:
- 化合物CDC25 PHOSPHATASE INHIBITOR I
- 4-(二甲基氨基)-2-甲氧基-6-[[甲基[2-(4-硝基苯基)乙基]氨基]甲基]苯酚
- 396073-89-5
- CDC25C,BN82002,CDC25A,BN-82002,inhibit,CDC25B3,MIA PaCa-2,Inhibitor,CDC25B2,BN 82002,Phosphatase
- Phenol, 4-(dimethylamino)-2-methoxy-6-[[methyl[2-(4-nitrophenyl)ethyl]amino]methyl]-
- CDC25 Phosphatase Inhibitor I
- CDC25 Phosphatase Inhibitor I, BN82002 - CAS 396073-89-5 - Calbiochem
- BN 82002;BN-82002
- CDC25 Phosphatase Inhibitor I, BN82002
- BN82002 hydrochloride