化合物ST1936 OXALATE

ST1936 appears to be relatively selective for 5-HT ₆ receptors, although it has shown affinity also for 5-HT _2B , 5-HT _1A , 5-HT ₇ receptor and α-adrenergic receptors when tested in a broad crossreactivity panel that comprised G-protein-coupled receptors, ion channel binding sites, enzymes, and transporters.

In-vivo electrophysiological studies are performed to investigate the physiological role of 5-HT ₆ receptors in the control of the function of the substantia nigra pars compacta (SNc) and ventral tegmental area (VTA). Extracellular single-unit recordings are performed from putative dopamine-containing neurons in the SNc and VTA of anesthetised rats (Male Sprague-Dawley rats). In the SNc, acute systemic administration of ST1936 (Intravenous injection; 50–1600 µg/kg for the SNc; 50–400 µg/kg for the VTA) has no effects on basal firing activity of these dopamine neurons; however, in the VTA, ST1936 induces either dose-related increases (45% of cells) or decreases in basal activity of these dopaminergic neurons.