化合物 T10469
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- CAS号:
- 2471978-97-7
- 英文名:
- 1,6-Naphthyridine-6(5H)-carboxamide, 5-(4-chlorophenyl)-N-[4-(4-fluorophenoxy)phenyl]-7,8-dihydro-, (5S)-
- 英文别名:
- BAY-298;PF-06873600 (free base);1,6-Naphthyridine-6(5H)-carboxamide, 5-(4-chlorophenyl)-N-[4-(4-fluorophenoxy)phenyl]-7,8-dihydro-, (5S)-
- 中文名:
- 化合物 T10469
- 中文别名:
- 化合物 T10469
- CBNumber:
- CB38189744
- 分子式:
- C27H21ClFN3O2
- 分子量:
- 473.93
- MOL File:
- 2471978-97-7.mol
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化合物 T10469化学性质
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沸点:
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653.6±55.0 °C(Predicted)
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密度:
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1.353±0.06 g/cm3(Predicted)
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酸度系数(pKa):
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12.36±0.70(Predicted)
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形态:
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Solid
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颜色:
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Off-white to light yellow
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化合物 T10469性质、用途与生产工艺
BAY-298 是一种口服有效和选择性的促黄体生成激素受体 (LH-R) 拮抗剂,对 hLH (人 LH),rLH (大鼠 LH)和 cLH (食蟹猴LH) 的 IC50 分别为 96 nM,23 nM 和 78 nM。BAY-298 可以降低性激素水平。
IC50: 185 nM (hLH), 46nM (rLH) and 78 nM (cLH)
BAY-298 (oral; 4.5-72 mg/kg/day; for 8 days) dosedependently loweres serum estradiol levels in proestrus.
BAY-298 (iv of 0.5 mg/kg or po of 2 mg/kg) has t
1/2
s of 31 hours and 33 hours for iv and po. And the C
max
s are 0.28 kg/L and 0.066 kg/L for iv and po.
Animal Model:
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Intact female rats
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Dosage:
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4.5, 9, 18, 36, 72 mg/kg
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Administration:
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Oral; for 8 days
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Result:
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Dosedependently lowered serum estradiol levels in proestrus.
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Animal Model:
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Female and male Wistar rats
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Dosage:
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0.5 mg/kg of iv or 2 mg/kg of po
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Administration:
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Iv or po
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Result:
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Has t
1/2
s of 31 hours and 33 hours for iv and po. And the C
max
s are 0.28 kg/L and 0.066 kg/L for iv and po.
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化合物 T10469
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/08/19 | HY-130249 | BAY-298 | | 1 mg | 2227元 |
2024/08/19 | HY-130249 | BAY-298 | 2471978-97-7 | 5mg | 4900元 |
2471978-97-7, 化合物 T10469 相关搜索:
- 化合物 T10469
- 2471978-97-7
- PF-06873600 (free base)
- BAY-298
- 1,6-Naphthyridine-6(5H)-carboxamide, 5-(4-chlorophenyl)-N-[4-(4-fluorophenoxy)phenyl]-7,8-dihydro-, (5S)-