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7,10-DIMETHYL-2,4-DIOXOBENZO[G]PTERIDINE-8-CARBALDEHYDE

7,10-DIMETHYL-2,4-DIOXOBENZO[G]PTERIDINE-8-CARBALDEHYDE, 37854-59-4, 结构式
7,10-DIMETHYL-2,4-DIOXOBENZO[G]PTERIDINE-8-CARBALDEHYDE
CAS号:
37854-59-4
英文名:
RO 08-2750
英文别名:
RO 08-2750;7,10-DIMETHYL-2,4-DIOXOBENZO[G]PTERIDINE-8-CARBALDEHYDE;7,10-dimethyl-2,4-dioxo-2,3,4,10-tetrahydrobenzo[g]pteridine-8-carbaldehyde;2,3,4,10-Tetrahydro-7,10-dimethyl-2,4-dioxobenzo[g]pteridine-8-carboxaldehyde;Benzo[g]pteridine-8-carboxaldehyde, 2,3,4,10-tetrahydro-7,10-dimethyl-2,4-dioxo-;growth,MSI,Ro 082750,p75NTR,TRKA,RNA-binding,Nerve,NGF,Inhibitor,leukemia,Apoptosis,AML,Ro 08-2750,inhibit,Ro 08 2750,factor,MUSASHI
中文名:
7,10-DIMETHYL-2,4-DIOXOBENZO[G]PTERIDINE-8-CARBALDEHYDE
中文别名:
化合物 T16766;化合物RO 08-2750
CBNumber:
CB3844689
分子式:
C13H10N4O3
分子量:
270.24
MOL File:
37854-59-4.mol

7,10-DIMETHYL-2,4-DIOXOBENZO[G]PTERIDINE-8-CARBALDEHYDE化学性质

储存条件:
Store at -20°C
溶解度:
≤2.7mg/ml in DMSO
形态:
solid
颜色:
Orange
安全信息

7,10-DIMETHYL-2,4-DIOXOBENZO[G]PTERIDINE-8-CARBALDEHYDE性质、用途与生产工艺

生物活性

Ro 08-2750 是一种非肽、可逆的 NGF 抑制剂,能直接结合 NGF,IC50 值为 ~ 1 µM。Ro 08-2750 能抑制 NGF 结合 p75NTR 的优于 TRKA。Ro 08-2750 是选择性的 MSI RNA 结合抑制剂,其作用的 IC50 值为 2.7 μM。

靶点

IC50: ~1 µM (NGF), 2.7 μM (MSI RNA-binding)

体外研究

Ro 08-2750 binds to the NGF dimer thereby probably inducing a change in its conformation such that NGF cannot bind to p75 NTR anymore.
Ro 08-2750 (10 nM) completely rescues cells from undergoing NGF-induced SK-N-MC 103 cells death.
Ro 08-2750 (5-10 μM; 8 hours) increases differentiation and apoptosis in myeloid leukemia cells.
Ro 08-2750 inhibits survival of human AML lines and patient cells.
Ro 08-2750 inhibits MSI2 RNA-binding and alters MSI2 gene signature.

Apoptosis Analysis

Cell Line: MLL-AF9 + BM cells
Concentration: 5 μM, 10 μM
Incubation Time: 8 hours
Result: Increased apoptosis.

体内研究

Ro 08-2750 (13.75 mg/kg; i.p.) inhibits leukemogenesis in a myeloid leukemia model in vivo.

Animal Model: C57BL/6 wild type mice (10-12-weeks-old), MLL-AF9 murine leukemia model
Dosage: 13.75 mg/kg
Administration: Intraperitoneal injection, at days 1, 4, 7, 10, and 13 (one day on, two days off drug)
Result: Inhibited c-MYC levels and reduced disease burden.

7,10-DIMETHYL-2,4-DIOXOBENZO[G]PTERIDINE-8-CARBALDEHYDE 上下游产品信息

上游原料

下游产品

7,10-DIMETHYL-2,4-DIOXOBENZO[G]PTERIDINE-8-CARBALDEHYDE 试剂级价格

更新日期产品编号产品名称CAS编号包装价格
2024/01/25HY-1084667,10-DIMETHYL-2,4-DIOXOBENZO[G]PTERIDINE-8-CARBALDEHYDE
Ro 08-2750
37854-59-41mg288元
2024/01/25HY-1084667,10-DIMETHYL-2,4-DIOXOBENZO[G]PTERIDINE-8-CARBALDEHYDE
Ro 08-2750
37854-59-45mg720元

7,10-DIMETHYL-2,4-DIOXOBENZO[G]PTERIDINE-8-CARBALDEHYDE 生产厂家

全球有 37家供应商   7,10-DIMETHYL-2,4-DIOXOBENZO[G]PTERIDINE-8-CARBALDEHYDE国内生产厂家
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武汉易泰科技有限公司上海分公司 821-50328103-801 18930552037 3bsc@sina.com 中国 15848 69
上海喀露蓝科技有限公司 18149758185 sales-cpd@caerulumpharma.com 中国 3404 58
EMMX Biotechnology LLC 888-539-0666 info@emmx.com 美国 8449 60
上海缮远医药科技有限公司 021-31761238 13167072949 3146446224@qq.com 中国 1607 55
常州平博医药研发有限公司 0519-83990708 lxy2046@yeah.net 中国 481 55
北京索莱宝科技有限公司 010-50973185 4009686088 3193328036@qq.com 中国 29797 68
北京普西唐生物科技有限公司 010-60605840 18892239720 psaitong@jm-bio.com 中国 12308 58
济南药研药物化学有限公司 jnyaoyan@163.com 中国 3069 58
南京美韬医药科技有限公司 meitaochem@126.com meitaochem@126.com 中国 19105 58
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 marketing@targetmol.com 美国 19892 58
InvivoChem +1-708-310-1919 +1-13798911105 sales@invivochem.cn 美国 6393 58
Changzhou PBpharmaceutical R&D Co.,Ltd 0519-83990708 info@pbpharm.com 中国 498 58
ChemeGen 中国 18818260767 sales@chemegen.com 中国 11289 58
MedBio脉铂医药 021-69568360 18916172912 order@med-bio.cn 中国 8141 58
天津普西唐生物医药科技有限公司 010-60605840 15801484223 psaitong@jm-bio.com 中国 29834 58
金瓯生物医药(南京)有限公司 13000000000 jinoupharma@163.com 中国 11732 58
上海优宁维生物科技股份有限公司 18768175414 gaojun@univ-bio.com 中国 24998 58
开封明仁药业有限公司 0371-65741762 sales@hasunny.com 中国 2380 58
InvivoChem中国 13549236410 sales@invivochem.cn 中国 6712 58
TargetMol中国(陶术生物) 4008200310 marketing@tsbiochem.com 中国 24131 58
河南阿尔法化工有限公司 0371-55013243 15324716602 2853979810@qq.com 中国 9295 58
上海一飞生物科技有限公司 021-65675885 18964387627 customer_service@efebio.com 中国 8740 58
上海瀚鸿科技股份有限公司 021-54306202 18917919676 info@hanhongsci.com 中国 29988 58
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 ivan@atkchemical.com 中国 32480 60
ApexBio技术 sales@apexbt.com 美国 6254 58
 

37854-59-4, 7,10-DIMETHYL-2,4-DIOXOBENZO[G]PTERIDINE-8-CARBALDEHYDE 相关搜索:

  • 化合物RO 08-2750
  • 化合物 T16766
  • 37854-59-4
  • 7,10-dimethyl-2,4-dioxo-2,3,4,10-tetrahydrobenzo[g]pteridine-8-carbaldehyde
  • growth,MSI,Ro 082750,p75NTR,TRKA,RNA-binding,Nerve,NGF,Inhibitor,leukemia,Apoptosis,AML,Ro 08-2750,inhibit,Ro 08 2750,factor,MUSASHI
  • Benzo[g]pteridine-8-carboxaldehyde, 2,3,4,10-tetrahydro-7,10-dimethyl-2,4-dioxo-
  • 7,10-DIMETHYL-2,4-DIOXOBENZO[G]PTERIDINE-8-CARBALDEHYDE
  • RO 08-2750
  • 2,3,4,10-Tetrahydro-7,10-dimethyl-2,4-dioxobenzo[g]pteridine-8-carboxaldehyde
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