盐酸艾替伏辛
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- CAS号:
- 56776-32-0
- 英文名:
- 6-chloro-N-ethyl-4-methyl-4-phenyl-4H-3,1-benzoxazin-2-amine monohydrochloride
- 英文别名:
- StresaM;Etifoxine HCl;HOE-36801 hydrochloride;Etifoxine·hydrochloride;Etifoxine HCl (HOE-36801);NSC 163501;ANTIBIOTIC AT-125;U 42126;2-EthylaMino-6-chloro-4-Methyl-4-phenyl-4H-3,1-benzoxazine Hydrochloride;6-Chloro-2-(ethylamino)-4-methyl-4-phenyl-4H-3,1-benzoxazine hydrochloride;6-Chloro-N-ethyl-4-Methyl-4-phenyl-4H-3,1-benzoxazin-2-aMine Hydrochloride;6-Chloro-2-N-ethyl-4-methyl-4-phenyl-4H-3,1-benzoxazin-2-aminehydrochloride
- 中文名:
- 盐酸艾替伏辛
- 中文别名:
- 盐酸艾替伏辛;盐酸依替福辛;艾替伏辛盐酸盐
- CBNumber:
- CB3883790
- 分子式:
- C17H18Cl2N2O
- 分子量:
- 337.24362
- MOL File:
- 56776-32-0.mol
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盐酸艾替伏辛化学性质
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熔点:
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ND
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储存条件:
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-20°C
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溶解度:
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DMSO: ≥5mg/mL
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形态:
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powder
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颜色:
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white to beige
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稳定性:
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Hygroscopic
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盐酸艾替伏辛性质、用途与生产工艺
Etifoxine hydrochloride是一个非苯二氮卓类的、具有 GABA 能的化合物，是 GABAA 受体亚基 α1β2γ2 和 α1β3γ2 的阳性变构调节剂。Etifoxine hydrochloride 在啮齿类动物中显示出抗焦虑和抗惊厥活性。
Etifoxine (EFX), at concentrations ranging from 10 to 300 μM (higher concentrations limited its solubility), produces a dose-dependent increase in the [3H]muscimol binding at equilibrium, to 155±2% of its control value at 300 μM EFX.
Etifoxine competitively inhibits [
35
S]TBPS binding with micromolar potency in rat brain.
Etifoxine (3.125-50 mg/kg) exhibits more pronounced anxiolytic and anticonvulsant effects in the BALB/cByJ mice compared to the C57BL/6J mice.
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Animal Model:
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Six-week old BALB/cByJ and C57BL/6J mice (20-25 g).
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Dosage:
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3.125-50 mg/kg.
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Administration:
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Intraperitoneal inhection.
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Result:
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Significantly increased the amount of time spent on the open arms at the 12.5 mg/kg dose when compared to vehicle (p = 0.009) in BALB/cByJ mice but produced no effect in C57B/6J mice.
BALB/cByJ mice compared with C57BL/6J mice exhibited significantly (p < 0.012) lower
plasma levels of the compound at 15 and 30 min.
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盐酸艾替伏辛
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/01/25 | HY-16579 | 盐酸艾替伏辛
Etifoxine hydrochloride | 56776-32-0 | 5mg | 700元 |
| 2024/01/25 | HY-16579 | 盐酸艾替伏辛
Etifoxine hydrochloride | 56776-32-0 | 10mM * 1mLin DMSO | 770元 |
56776-32-0, 盐酸艾替伏辛 相关搜索:
- API
- Pharmaceuticals
- Intermediates & Fine Chemicals
- Heterocycles
- Amines
- C17H17ClN2OHCl
- 盐酸依替福辛
- 艾替伏辛盐酸盐
- 盐酸艾替伏辛
- 56776-32-0
- Etifoxine HCl (HOE-36801)
- TBPS,Anxiolytic,Etifoxine hydrochloride,γ-Aminobutyric acid Receptor,disorder,HOE 36-801,inhibit,adjustment,Etifoxine,Inhibitor,Gamma-aminobutyric acid Receptor,GABA Receptor
- NSC 163501;ANTIBIOTIC AT-125;U 42126
- Etifoxine HCl
- HOE-36801 hydrochloride
- 6-Chloro-2-(ethylamino)-4-methyl-4-phenyl-4H-3,1-benzoxazine hydrochloride
- StresaM
- 6-Chloro-N-ethyl-4-Methyl-4-phenyl-4H-3,1-benzoxazin-2-aMine Hydrochloride
- 2-EthylaMino-6-chloro-4-Methyl-4-phenyl-4H-3,1-benzoxazine Hydrochloride
- 6-Chloro-2-N-ethyl-4-methyl-4-phenyl-4H-3,1-benzoxazin-2-aminehydrochloride
- Etifoxine·hydrochloride
- 6-chloro-N-ethyl-4-methyl-4-phenyl-4H-3,1-benzoxazin-2-amine monohydrochloride