诺次黄嘌呤外消旋体
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- CAS号:
- 75166-67-5
- 英文名:
- 1,9-dihydro-9-[1-(1-hydroxyethyl)heptyl]-6H-purin-6-one
- 英文别名:
- Erimunol;NPT-15392 racemate;Nosantine (racemate);9-[1-(1-Hydroxyethyl)heptyl]hypoxanthine;1,9-dihydro-9-[1-(1-hydroxyethyl)heptyl]-6H-purin-6-one;6H-Purin-6-one, 1,9-dihydro-9-[1-(1-hydroxyethyl)heptyl]-
- 中文名:
- 诺次黄嘌呤外消旋体
- 中文别名:
- 诺次黄嘌呤外消旋体;化合物 T12245
- CBNumber:
- CB3917695
- 分子式:
- C14H22N4O2
- 分子量:
- 278.35
- MOL File:
- 75166-67-5.mol
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诺次黄嘌呤外消旋体化学性质
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沸点:
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539.1±30.0 °C(Predicted)
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密度:
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1.27±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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酸度系数(pKa):
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8.84±0.70(Predicted)
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诺次黄嘌呤外消旋体性质、用途与生产工艺
Nosantine racemate 是 Nosantine 的外消旋体。Nosantine是一种 IL-2 诱导剂或诱导 IL-2 的增强剂。
The purine immunoenhancing drug Nosantine (NPT 15392) is evaluated as an inducer of IL-2 or enhancer of IL-2 induction by phytohemagglutinin (PHA). Nosantine is found to has significant enhancing activity on PHA induction of IL-2 by human lymphocytes over a wide range of concentrations.
Multiple concomitant immune responses are assessed in individual rats following treatment with the immunoenhancing drugs, Isoprinosine (5 or 50 mg/kg), Nosantine (0.1 or 1.0 mg/kg) and Avridine (1 or 25 mg/kg), or the immunosuppressant, Cyclophosphamide (75 mg/kg). Rats treated with Nosantine (NPT 15392) have significantly enhanced DTH reactions at the 0.1 mg/kg dose. It can be concluded that NPT 15392 act as general immunostimulants in the rat, with avridine having the greatest effect under these experimental conditions.
诺次黄嘌呤外消旋体
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75166-67-5, 诺次黄嘌呤外消旋体 相关搜索:
- 化合物 T12245
- 诺次黄嘌呤外消旋体
- 75166-67-5
- NPT-15392 racemate
- 6H-Purin-6-one, 1,9-dihydro-9-[1-(1-hydroxyethyl)heptyl]-
- Nosantine (racemate)
- Erimunol
- 9-[1-(1-Hydroxyethyl)heptyl]hypoxanthine
- 1,9-dihydro-9-[1-(1-hydroxyethyl)heptyl]-6H-purin-6-one