哌卡嗪盐酸盐
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- CAS号:
- 2975-36-2
- 英文名:
- 10-[(1-methyl-3-piperidyl)methyl]-10H-phenothiazine monohydrochloride
- 英文别名:
- Mepazine hydrochloride;10-((1-methylpiperidin-3-yl)methyl)-10H-phenothiazine hydrochloride;10-[(1-methyl-3-piperidyl)methyl]-10H-phenothiazine monohydrochloride;10H-Phenothiazine, 10-[(1-methyl-3-piperidinyl)methyl]-,monohydrochloride
- 中文名:
- 哌卡嗪盐酸盐
- 中文别名:
- 哌卡嗪盐酸盐;甲哌啶嗪盐酸盐;化合物 MEPAZINE HYDROCHLORIDE
- CBNumber:
- CB3921722
- 分子式:
- C19H23ClN2S
- 分子量:
- 346.91732
- MOL File:
- 2975-36-2.mol
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哌卡嗪盐酸盐化学性质
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熔点:
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180-181 °C
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沸点:
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180-183 °C(Press: 0.5 Torr)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO: 50 mg/mL (144.13 mM)
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哌卡嗪盐酸盐性质、用途与生产工艺
Mepazine hydrochloride (Pecazine hydrochloride) 是一种有效的选择性 MALT1 蛋白酶抑制剂。Mepazine hydrochloride 抑制全长 GSTMALT1 和 GSTMALT1 325-760 段的IC50 分别为 0.83 和 0.42 μM。Mepazine hydrochloride 通过增强细胞凋亡 (apoptosis) 来影响 ABC-DLBCL 细胞的生存能力。
Mepazine (5-20 μM; 4 days) causes a decrease of cell viability in the activated B cell subtype of diffuse large B cell lymphoma (ABCDLBCL) cells, without significantly affecting GCB-DLBCL cells.
Cell Viability Assay
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Cell Line:
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ABC-DLBCL cell lines (HBL1, OCI-Ly3, U2932, TMD8, OCI-Ly10) and GCB-DLBCL cell lines (BJAB, Su-DHL-6, Su-DHL-4)
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Concentration:
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5, 10, and 20 μM
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Incubation Time:
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4 days
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Result:
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Caused a decrease of cell viability in the ABC-DLBCL cells HBL1, OCI-Ly3, U2932, and TMD8, without significantly affecting GCB-DLBCL cells.
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Mepazine (16 mg/kg; intraperitoneal administration) interferes with growth and induces apoptosis of ABC-DLBCL cell line OCI-Ly10 in NOD/scid IL-2Rg
null
(NSG) mice with a murine DLBCL xenogeneic tumor model. Daily administration of Mepazine strongly impairs the expansion of the ABC-DLBCL cell line OCI-Ly10.
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Animal Model:
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6- to 8-week-old female NOD.Cg-
Prkdc
scid
Il2rg
tm1Wjl
/SzJ (NSG) mice with a murine DLBCL xenogeneic tumor model
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Dosage:
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400 μg per animal (25 g), corresponding to approximately 16 mg/kg
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Administration:
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Intraperitoneal administration; started 1 or 12 days after transplantation and given continuously every 24 hr; daily application
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Result:
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Daily administration strongly impaired the expansion of the ABC-DLBCL cell line OCI-Ly10.
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哌卡嗪盐酸盐
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-121282A | 哌卡嗪盐酸盐
Mepazine hydrochloride | 2975-36-2 | 25 mg | 1150元 |
| 2024/01/25 | HY-121282A | 哌卡嗪盐酸盐
Mepazine hydrochloride | 2975-36-2 | 10mM * 1mLin DMSO | 1270元 |
2975-36-2, 哌卡嗪盐酸盐 相关搜索:
- 抑制剂
- 有机化工原料
- 化合物 MEPAZINE HYDROCHLORIDE
- 甲哌啶嗪盐酸盐
- 哌卡嗪盐酸盐
- 2975-36-2
- Mepazine hydrochloride
- 10H-Phenothiazine, 10-[(1-methyl-3-piperidinyl)methyl]-,monohydrochloride
- 10-((1-methylpiperidin-3-yl)methyl)-10H-phenothiazine hydrochloride
- 10-[(1-methyl-3-piperidyl)methyl]-10H-phenothiazine monohydrochloride