1,2:5,6-二脱水半乳糖醇
|
|
- CAS号:
- 23261-20-3
- 英文名:
- Dianhydrogalactitol
- 英文别名:
- 1,2:5,6-Dianhydrogalactitol;VAL-083;VAL083;VAL 083;NSC-132313;Dulcitol diepoxide;Dianhydrodulcitolum;Dianhydrogalactitol;5,6-Diepoxydulcitol;1,2:5,6-Diepoxydulcitol
- 中文名:
- 1,2:5,6-二脱水半乳糖醇
- 中文别名:
- 去水卫矛醇;卫矛醇二环氧化物;VAL-083,烷化剂;1,2:5,6-二脱水半乳糖醇
- CBNumber:
- CB41016710
- 分子式:
- C6H10O4
- 分子量:
- 146.14
- MOL File:
- 23261-20-3.mol
|
|
|
1,2:5,6-二脱水半乳糖醇化学性质
-
熔点:
-
96.5-98.5 °C
-
|
-
沸点:
-
185.74°C (rough estimate)
-
|
-
密度:
-
1.567
-
|
-
折射率:
-
1.4310 (estimate)
-
|
-
储存条件:
-
Store at -20°C
-
|
-
溶解度:
-
Soluble in DMSO
-
|
-
形态:
-
Powder
-
|
-
酸度系数(pKa):
-
13.53±0.20(Predicted)
-
|
-
颜色:
-
White to off-white
-
|
1,2:5,6-二脱水半乳糖醇性质、用途与生产工艺
VAL-083 是一种烷化剂 (alkylator),能够在 DNA 上产生 N7 甲基化,具有抗肿瘤活性。
VAL-083 is an alkylating agent that creates N7 methylation on DNA. VAL-083 suppresses U251 and SF188 cell growth and induces apoptosis after 72 h. VAL-083 (5 μM) inhibits the growth of SF188 by ∼95%. VAL-083 inhibits T98G cells growth in a dose-dependent manner (IC
50
<5 μM). VAL-083 (Dianhydrogalactitol) inhibits the proliferation of HUVEC and U251 cells at doses of more than 12.5 μg/mL. VAL-083 (3.125, 6.25, 12.5 μg/mL) also suppresses the migration and invasion, and reduces MMP2, VEGF, VEGFR2, and FGF2 expression in HUVEC and U251 cells. VAL-083 (1,2:5,6-dianhydrogalactitol, 1, 2, 5 μM) dose-dependently induces cell cycle arrest at G2/M phase in the 3 glioma cell lines. VAL-083 activates two parallel signaling cascades, the p53-p21 and the CDC25C-CDK1 cascade. In addition, VAL-083 significantly enhances the radiosensitivity of LN229 cells.
VAL-083 (Dianhydrogalactitol; 25, 50, 100 μg/mL) dose-dependently inhibits angiogenesis in zebrafish model. VAL-083 considerably reduces VEGF, VEGFR2, and FGF2 expression at 25 μg/mL, and further causes reduction in FGFR2 expression at 50 μg/mL. VAL-083 (1,2:5,6-dianhydrogalactitol; 5 mg/kg, iv, twice per week for 6 weeks) significantly blocks the growth of LN229 cells in mice with the relative tumor growth rate (T/C) of 22.38%, and the tumor growth inhibitory rate (TGI) of 83.58%. Moreover, VAL-083 dramatically activates the CDC25C-CDK1 cascade in the xenografted tumor moedl.
1,2:5,6-二脱水半乳糖醇
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
---|
2024/08/19 | HY-16513 | VAL-083 | | 1 mg | 800元 |
2024/08/19 | HY-16513 | 1,2:5,6-二脱水半乳糖醇 VAL-083 | 23261-20-3 | 5mg | 1600元 |
23261-20-3, 1,2:5,6-二脱水半乳糖醇 相关搜索:
- APIS
- 药靶配体
- 中药对照品
- 标准品
- 细胞周期
- VAL-083,烷化剂
- 去水卫矛醇
- 卫矛醇二环氧化物
- 1,2:5,6-二脱水半乳糖醇
- 23261-20-3
- VAL-083,Inhibitor,DNA Alkylator/Crosslinker,VAL 083,inhibit,VAL083
- VAL-083,Dianhydrodulcitol
- 1,2:5,6-Dianhydrogalactitol
- VAL083
- VAL-083
- Dianhydrodulcitol USP/EP/BP
- Galactitol, 1,2:5,6-dianhydro-
- VAL083; VAL083; VAL083; DIANHYDRODULCITOL; DIANHYDROGALACTITOL; DULCITOL DIEPOXIDE;
- VAL 083
- 5,6-Diepoxydulcitol
- 1,2:5,6-Diepoxydulcitol
- NSC-132313
- Dulcitol diepoxide
- 1,2-Di(oxiranyl)ethylene glycol
- 1,2:5,6-Diepoxyhexane-3,4-diol
- 1,2,5,6-DIANHYDRODULCITOL
- Dianhydrodulcitolum
- Dianhydrogalactitol