奴文西平
|
|
- CAS号:
- 96487-37-5
- 英文名:
- Nuvenzepine
- 英文别名:
- K-545;Nuvenzepine;11-(1-methylpiperidine-4-carbonyl)-6H-pyrido[3,2-c][1,5]benzodiazepin-5-one;6,11-Dihydro-11-[(1-methyl-4-piperidinyl)carbonyl]-5H-pyrido[2,3-b][1,5]benzodiazepin-5-one;5H-Pyrido[2,3-b][1,5]benzodiazepin-5-one, 6,11-dihydro-11-[(1-methyl-4-piperidinyl)carbonyl]-
- 中文名:
- 奴文西平
- 中文别名:
- 奴文西平;化合物 T16362
- CBNumber:
- CB41118339
- 分子式:
- C19H20N4O2
- 分子量:
- 336.39
- MOL File:
- 96487-37-5.mol
|
|
|
奴文西平化学性质
-
沸点:
-
522.3±50.0 °C(Predicted)
-
|
-
密度:
-
1.267±0.06 g/cm3(Predicted)
-
|
-
储存条件:
-
Store at -20°C
-
|
-
溶解度:
-
Soluble in DMSO
-
|
-
酸度系数(pKa):
-
10.99±0.20(Predicted)
-
|
奴文西平性质、用途与生产工艺
Nuvenzepine是 mAChR 的拮抗剂,有潜力用于胃痉挛的研究。
Nuvenzepine shows a four-fold higher affinity than pirenzepine in competitively antagonizing acetylcholine-induced contractions on isolated ileal musculature and on longitudinal ileum dispersed cells. Nuvenzepine is almost equipotent to pirenzepine in competitively preventing bethanechol-induced gall-bladder contractions and it displays a four-fold higher potency than pirenzepine in blocking vagal-stimulated tracheal constrictions.
Intraduodenally administration of Nuvenzepine displays a long-lasting and dose-dependent inhibition of neostigmine-induced intestinal motility in anaesthetized cats. On ileal motor activity, Nuvenzepine shows a potency 10 times greater than that of pirenzepine. Nuvenzepine is also active, unlike pirenzepine, on colonic stimulated motility. Furthermore, in conscious cats, Nuvenzepine inhibits pentagastrin-stimulated gastric acid secretion resulting 25-30 times more potent than pirenzepine. Nuvenzepine has been found to be very active in inhibiting gastric acid secretion and intestinal hypermotility in rats, with very slight atropine-like side effects. The oral absorption rate is relatively slow, that the absolute bioavailability is 30 to 40%, that the elimination rate is slow and there is no accumulation in the body, and that there is very little metabolism.
奴文西平
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
---|
2024/01/25 | HY-U00119 | 奴文西平 Nuvenzepine | 96487-37-5 | 1mg | 2000元 |
2024/01/25 | HY-U00119 | 奴文西平 Nuvenzepine | 96487-37-5 | 5mg | 4000元 |
96487-37-5, 奴文西平 相关搜索:
- 化合物 T16362
- 奴文西平
- 96487-37-5
- 11-(1-methylpiperidine-4-carbonyl)-6H-pyrido[3,2-c][1,5]benzodiazepin-5-one
- 5H-Pyrido[2,3-b][1,5]benzodiazepin-5-one, 6,11-dihydro-11-[(1-methyl-4-piperidinyl)carbonyl]-
- K-545
- 6,11-Dihydro-11-[(1-methyl-4-piperidinyl)carbonyl]-5H-pyrido[2,3-b][1,5]benzodiazepin-5-one
- Nuvenzepine