伏立康唑N-氧化物
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- CAS号:
- 618109-05-0
- 英文名:
- Voriconazole N-Oxide
- 英文别名:
- UK 12126;UK 121265;VORICOZOLE N-OXIDE;Voriconazole N-Oxide;Voriconazole oxynitride;Voriconazole N-Oxide HCl;Voriconazole oxide 13C2D3;Voriconazole N-oxide formate salt;(2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoro-1-oxidopyrimidin-1-ium-4-yl)-1-(1,2,4-triazol-1-yl)butan-2-ol;(aR,S)-a-(2,4-Difluorophenyl)-5-fluoro--methyl-a-(1H-1,2,4-triazol-1-ylmethyl)-1-oxide-4-pyrimidineethanol
- 中文名:
- 伏立康唑N-氧化物
- 中文别名:
- 伏立康唑杂质08;伏立康唑氮氧化物;伏立康唑N-氧化物;伏立康唑氮氧化合物;伏立康唑N-氧化物盐酸盐;伏立康唑氮氧化物(盐酸盐);(2R,3S)-2-(2,4-二氟苯基)-3-(5-氟-1-氧代-4-嘧啶基)-1-(1H-1,2,4-三唑-1-基)-2-丁醇
- CBNumber:
- CB41176858
- 分子式:
- C16H14F3N5O2
- 分子量:
- 365.32
- MOL File:
- 618109-05-0.mol
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伏立康唑N-氧化物化学性质
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熔点:
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75-77°C
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沸点:
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569.5±60.0 °C(Predicted)
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密度:
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1.47±0.1 g/cm3(Predicted)
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储存条件:
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-20°C Freezer, Under Inert Atmosphere
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溶解度:
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Chloroform: slightly soluble; Methanol: slightly soluble
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形态:
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A solid
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酸度系数(pKa):
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11.22±0.29(Predicted)
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伏立康唑N-氧化物性质、用途与生产工艺
伏立康唑的主要代谢物为伏立康唑N-氧化物(voriconazoleN-oxide，VNO)，主要通过细胞色素CYP450氧化酶包括CYP3A4、CYP2C19和CYP2C9代谢，其中CYP2C19是主要的代谢酶。伏立康唑N-氧化物抗真菌活性弱，研究表明伏立康唑N-氧化物可以抑制CYP3A4或CYP2C19的体外代谢活性。
伏立康唑N-氧化物
上下游产品信息
上游原料
下游产品
618109-05-0, 伏立康唑N-氧化物 相关搜索:
VoriconazoleImpurity15 伏立康唑杂质7 Α-(2,4-二氟苯基)-5-氟-Β-甲基-Α-(1,2,4-三唑-1-甲基)-4-嘧啶乙醇 2,4-二氯-6-乙基-5-氟嘧啶 伏立康唑杂质7 伏立康唑杂质11 rel-(R,R)-伏立康唑 伏立康唑杂质8 2-CHLORO-1-(2,6-DIFLUOROPHENYL)ETHAN-1-ONE 2-氯-6-乙基-5-氟-4-羟基嘧啶胺盐 (2R,3S/2S,3R)-3-(6-氯-5-氟嘧啶-4-基)-2-(2,4-二氟苯基)-1-(1H-1,2,4-三唑-1-基)-2-丁醇盐酸盐 Pyrimidine,4-chloro-6-(1,1-dibromoethyl)-5-fluoro- 消旋5-伏立康唑 4-(1-溴代乙基)-5-氟-6-氯嘧啶 Voriconazole-13C3,d3 rel-(R,S)-Voriconazole-d3 伏立康唑中间体 4-乙基-5-氟嘧啶
- Pharmaceuticals
- Metabolites & Impurities
- Intermediates & Fine Chemicals
- 标准品
- 杂质对照品
- 伏立康唑
- C16H14F3N5O2
- 伏立康唑氮氧化物(盐酸盐)
- 伏立康唑氮氧化合物
- 伏立康唑N-氧化物盐酸盐
- (2R,3S)-2-(2,4-二氟苯基)-3-(5-氟-1-氧代-4-嘧啶基)-1-(1H-1,2,4-三唑-1-基)-2-丁醇
- 伏立康唑杂质08
- 伏立康唑氮氧化物
- 伏立康唑N-氧化物
- 618109-05-0
- VORICOZOLE N-OXIDE
- Voriconazole N-Oxide HCl
- Voriconazole oxide 13C2D3
- Voriconazole N oxideQ: What is
Voriconazole N oxide Q: What is the CAS Number of
Voriconazole N oxide Q: What is the storage condition of
Voriconazole N oxide Q: What are the applications of
Voriconazole N oxide
- 4-[(2S,3R)-3-(2,4-Difluorophenyl)-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)butan-2-yl]-5-fluoropyrimidin-1-ium-1-olate
- Voriconazole N-oxide formate salt
- 4-Pyrimidineethanol, α-(2,4-difluorophenyl)-5-fluoro-β-methyl-α-(1H-1,2,4-triazol-1-ylmethyl)-, 1-oxide, (αR,βS)-
- (2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoro-1-oxidopyrimidin-1-ium-4-yl)-1-(1,2,4-triazol-1-yl)butan-2-ol
- Voriconazole oxynitride
- 4-((2S,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)butan-2-yl)-5-fluoropyrimidine 1-oxide
- (aR,bS)-a-(2,4-Difluorophenyl)-5-fluoro-b-methyl-a-(1H-1,2,4-triazol-1-ylmethyl)-1-oxide-4-pyrimidineethanol
- UK 121265
- (aR,S)-a-(2,4-Difluorophenyl)-5-fluoro--methyl-a-(1H-1,2,4-triazol-1-ylmethyl)-1-oxide-4-pyrimidineethanol
- Voriconazole N-Oxide
- UK 12126
- (αR,βS)-α-(2,4-Difluorophenyl)-5-fluoro-β-Methyl-α-(1H-1,2,4-triazol-1-ylMethyl)-1-oxide-4-pyriMidineethanol