7-羟基-4-胆甾烯-3-酮
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- CAS号:
- 3862-25-7
- 英文名:
- (7R,8S,9S,10R,13R,14S,17R)-7-hydroxy-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
- 英文别名:
- 7α-hydroxy-4-Cholesten-3-one;7alpha-hydroxycholest-4-en-3-one;7HCO;alpha-HC;7α-hydroxycholestenone;Δ4-7α-hydrocholesterol;7α-hydroxy cholestenone;4-CHOLESTEN-7α-OL-3-ONE;7a-Hydroxy-cholestene-3-one;7-Hydroxy-4-cholesten-3-one
- 中文名:
- 7-羟基-4-胆甾烯-3-酮
- 中文别名:
- 7Α-羟基胆甾烯酮;化合物 T10196;7-羟基-4-胆甾烯-3-酮;7Α-羟基-4-胆甾烯-3-酮;7A-羟基-4-胆甾烯-3-酮;7Α-羟基-4-胆固醇-3-酮;7-羟基-4-胆甾烯-3-酮 标准品;7Α-羟基- 4 -胆固醇-3 -酮
- CBNumber:
- CB41235636
- 分子式:
- C27H44O2
- 分子量:
- 400.64
- MOL File:
- 3862-25-7.mol
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7-羟基-4-胆甾烯-3-酮化学性质
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熔点:
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182-184°C
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沸点:
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516.7±29.0 °C(Predicted)
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密度:
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1.03±0.1 g/cm3(Predicted)
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储存条件:
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-20°C Freezer
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溶解度:
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Chloroform (Slightly), Methanol (Slightly)
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形态:
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Solid
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酸度系数(pKa):
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14.49±0.70(Predicted)
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颜色:
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White to Off-White
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7-羟基-4-胆甾烯-3-酮性质、用途与生产工艺
7α-Hydroxy-4-cholesten-3-one 是一种由胆固醇合成胆汁酸的中间体。7α-Hydroxy-4-cholesten-3-one 是一种孕烷 X 受体 (PXR) 激动剂。7α-Hydroxy-4-cholesten-3-one 是胆汁酸流失，肠易激综合征和其他与胆汁酸生物合成缺陷有关的疾病的生物标志物。7α-Hydroxy-cholest-4-en-3-one 也是一种 CYP8B1 的生理底物。
Endogenous Metabolite
Pregnane X receptor (PXR)
7α-Hydroxy-4-cholesten-3-one is found relatively upstream in the biosynthetic pathway to bile acids (e.g. chenodeoxycholic acid). The first step is the incorporation of the 7α-hydroxy group onto cholesterol by cytochrome P450 7A1, and the second step is the oxidation and isomerization of the 3-hydroxy group and the Δ5,6-double bond by 3β-hydroxy steroid dehydrogenase to yield 7α-Hydroxy-4-cholesten-3-one. The deletion of the gene that expresses P450 27A1, which is found downstream in the bile acid pathway, results in the accumulation of the precursor, 7α-Hydroxy-4-cholesten-3-one.
7α-Hydroxy-4-cholesten-3-one strongly relates to the hepatic enzymatic activity of CYP7A1 at steady-state conditions as well as during the rapid diurnal changes that occur in the rat. That serum 7α-Hydroxy-4-cholesten-3-one has a pronounced diurnal rhythm.
7-羟基-4-胆甾烯-3-酮
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/01/25 | HY-113259 | 7-羟基-4-胆甾烯-3-酮
7α-Hydroxy-4-cholesten-3-one | 3862-25-7 | 1mg | 3500元 |
3862-25-7, 7-羟基-4-胆甾烯-3-酮 相关搜索:
- Steroids
- Pharmaceuticals
- Metabolites & Impurities
- Intermediates & Fine Chemicals
- Various Metabolites and Impurities
- 抑制剂
- 脂类
- 7Α-羟基-4-胆甾烯-3-酮
- 7Α-羟基胆甾烯酮
- 7A-羟基-4-胆甾烯-3-酮
- 化合物 T10196
- 7Α-羟基-4-胆固醇-3-酮
- 7-羟基-4-胆甾烯-3-酮 标准品
- 7Α-羟基- 4 -胆固醇-3 -酮
- 7-羟基-4-胆甾烯-3-酮
- 3862-25-7
- 4-CHOLESTEN-7α-OL-3-ONE
- 7α Hydroxy 4 cholesten 3 one,7αHydroxy4cholesten3one
- 2H7]-7-α-Hydroxy-4-cholesten-3-one
- 7α-hydroxy cholestenone
- 7α-hydroxy-4-Cholesten-3-one
- 7alpha-hydroxycholest-4-en-3-one
- Cholest-4-en-3-one, 7-hydroxy-, (7α)-
- Δ4-7α-hydrocholesterol
- 7-Hydroxy-4-cholesten-3-one
- alpha-HC
- 7α-hydroxycholestenone
- 7Α-HYDROXY-4-CHOLESTEN-3-ONE;7Α-HYDROXYCHOLESTENONE;7HCO;ALPHA-HC;Α-HC
- 7HCO
- (7R,8S,9S,10R,13R,14S,17R)-7-hydroxy-10,13-diMethyl-17-((R)-6-Methylheptan-2-yl)-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3(2H)-one
- (7R,8S,9S,10R,13R,14S,17R)-7-hydroxy-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
- 7a-Hydroxycholest-4-en-3-one
- 7a-Hydroxy-4-cholesten-3-one
- (7a)-7-Hydroxycholest-4-en-3-one
- 7 alpha-hydroxy-4-cholesten-3-one
- 7a-Hydroxy-cholestene-3-one