网站主页 >> CAS数据库列表 >> (2S)-2-[[5-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(phosphonooxymethyl)oxolan-2-yl]imidazole-4-carbonyl]amino]butanedioic acid
(2S)-2-[[5-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(phosphonooxymethyl)oxolan-2-yl]imidazole-4-carbonyl]amino]butanedioic acid
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- CAS号:
- 3031-95-6
- 英文名:
- (2S)-2-[[5-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(phosphonooxymethyl)oxolan-2-yl]imidazole-4-carbonyl]amino]butanedioic acid
- 英文别名:
- SAICAR;Succino-AICAR;5-Aminoimidazole-4-N-succinocarboxamide ribonucleotide;5'-Phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole;N-Succinyl-5-aMinoiMidazole-4-carboxaMide Ribose 5'-Phosphate;N-[[5-Amino-1-(5-O-phosphono-β-D-ribofuranosyl)-1H-imidazol-4-yl]carbonyl]-L-aspartic acid;N-[[5-Amino-1-(5-O-phosphono-b-D-ribofuranosyl)-1H-imidazoL-4-yl]carbonyl]-L-aspartic acid;L-Aspartic acid, N-[[5-amino-1-(5-O-phosphono-β-D-ribofuranosyl)-1H-imidazol-4-yl]carbonyl]-;2-[[1-(5-O-Phosphono-β-D-ribofuranosyl)-5-amino-1H-imidazol]-4-ylcarbonylamino]succinic acid;(2S)-2-[[5-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(phosphonooxymethyl)oxolan-2-yl]imidazole-4-carbonyl]amino]butanedioic acid
- 中文名:
- (2S)-2-[[5-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(phosphonooxymethyl)oxolan-2-yl]imidazole-4-carbonyl]amino]butanedioic acid
- 中文别名:
- 化合物 T16837;N-琥珀酰-5-氨基咪唑-4-甲酰胺核糖5'-磷酸
- CBNumber:
- CB41236244
- 分子式:
- C13H19N4O12P
- 分子量:
- 454.28
- MOL File:
- 3031-95-6.mol
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(2S)-2-[[5-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(phosphonooxymethyl)oxolan-2-yl]imidazole-4-carbonyl]amino]butanedioic acid化学性质
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熔点:
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>189°C (dec.)
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密度:
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2.18±0.1 g/cm3(Predicted)
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储存条件:
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Hygroscopic, -20°C Freezer, Under inert atmosphere
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溶解度:
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Methanol (Slightly), Water (Slightly)
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形态:
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Solid
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酸度系数(pKa):
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1.86±0.10(Predicted)
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颜色:
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White to Off-White
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稳定性:
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Hygroscopic
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(2S)-2-[[5-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(phosphonooxymethyl)oxolan-2-yl]imidazole-4-carbonyl]amino]butanedioic acid性质、用途与生产工艺
N-琥珀酰基-5-氨基咪唑-4-羧酰胺5'-磷酸核糖是嘌呤代谢产物。 由于腺苷是神经元功能的有效抑制剂,可抑制几种兴奋递质的释放并引发神经元的直接过级化,因此腺苷琥珀酸裂合酶(ASase)缺乏症患者出现的症状可能反映了琥珀酰嘌呤对神经传递的干扰。
SAICAR 是嘌呤核苷酸从头合成的中间体,以同工酶选择性性方式激活 PKM2,EC50 为 0.3 mM。SAICAR 刺激 PKM2 并促进癌细胞在葡萄糖限制条件下的存活。
Human Endogenous Metabolite
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SAICAR accumulation induces nuclear localization of PKM2. PKM2-SAICAR phosphorylates and activates Erk1/2, which in turn sensitizes PKM2 for SAICAR binding through phosphorylation. Additionally, PKM2-SAICAR was necessary to induce sustained Erk1/2 activation and mitogen-induced cell proliferation. SAICAR-PKM2 interaction is necessary and sufficient to induce H3 T11 and Erk1/2 phosphorylation.
Upon glucose starvation, cellular SAICAR concentration increases in an oscillatory manner and stimulates PKM2 activity in cancer cells. The SAICAR-PKM2 interaction also promotes cancer cell survival in glucose-limited conditions. In glucose-limited conditions, cells with higher SAICAR concentrations (
adsl-kd
cells or cells overexpressing PAICS) survive better while
paics-kd
cells died earlier than control-kd cells. SAICAR promotes cancer cell survival in glucose-limited conditions.
(2S)-2-[[5-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(phosphonooxymethyl)oxolan-2-yl]imidazole-4-carbonyl]amino]butanedioic acid
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/01/25 | HY-126585 | (2S)-2-[[5-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(phosphonooxymethyl)oxolan-2-yl]imidazole-4-carbonyl]amino]butanedioic acid SAICAR | 3031-95-6 | 500μg | 2000元 |
2024/01/25 | HY-126585 | (2S)-2-[[5-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(phosphonooxymethyl)oxolan-2-yl]imidazole-4-carbonyl]amino]butanedioic acid SAICAR | 3031-95-6 | 1mg | 3400元 |
(2S)-2-[[5-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(phosphonooxymethyl)oxolan-2-yl]imidazole-4-carbonyl]amino]butanedioic acid
生产厂家
3031-95-6, (2S)-2-[[5-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(phosphonooxymethyl)oxolan-2-yl]imidazole-4-carbonyl]amino]butanedioic acid 相关搜索:
- C13H19N4O12P
- N-琥珀酰-5-氨基咪唑-4-甲酰胺核糖5'-磷酸
- 化合物 T16837
- 3031-95-6
- N-[[5-Amino-1-(5-O-phosphono-b-D-ribofuranosyl)-1H-imidazoL-4-yl]carbonyl]-L-aspartic acid
- L-Aspartic acid, N-[[5-amino-1-(5-O-phosphono-β-D-ribofuranosyl)-1H-imidazol-4-yl]carbonyl]-
- SAICAR
- N-Succinyl-5-aMinoiMidazole-4-carboxaMide Ribose 5'-Phosphate
- 5'-Phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole
- 5-Aminoimidazole-4-N-succinocarboxamide ribonucleotide
- 2-[[1-(5-O-Phosphono-β-D-ribofuranosyl)-5-amino-1H-imidazol]-4-ylcarbonylamino]succinic acid
- Succino-AICAR
- N-[[5-Amino-1-(5-O-phosphono-β-D-ribofuranosyl)-1H-imidazol-4-yl]carbonyl]-L-aspartic acid
- (2S)-2-[[5-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(phosphonooxymethyl)oxolan-2-yl]imidazole-4-carbonyl]amino]butanedioic acid