KP136
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- CAS号:
- 76239-32-2
- 英文名:
- KP 136
- 英文别名:
- KP 136;AL-136;KP-136,KP136;8-(Hexyloxy)-3-(1H-tetrazol-5-yl)coumarin;8-(Hexyloxy)-3-(1H-tetrazol-5-yl)-2H-1-benzopyran-2-one;2H-1-Benzopyran-2-one, 8-(hexyloxy)-3-(2H-tetrazol-5-yl)-
- 中文名:
- KP136
- 中文别名:
- 化合物 T15666
- CBNumber:
- CB41332245
- 分子式:
- C16H18N4O3
- 分子量:
- 314.343
- MOL File:
- 76239-32-2.mol
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KP136化学性质
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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KP136性质、用途与生产工艺
KP136 (AL136) 是一种有效的，具有口服活性的抗过敏剂。抑制组胺释放和细胞脱粒，IC50 分别为 76.1 μg/mL 和 63 μg/mL。
KP136 (0.01 μg/mL) inhibits this histamine release and degranulation in a dose-dependent manner, confirming that it is an inhibitor of mast cell activation. The IC
50
is 76.1 μg/mL for histamine release and 63 ug/mL for degranulation.
C4C at 0.2 mg/kg produces an equipotent effect to 1 mg/kg KP136 (KP-136) or 5 mg/kg DSCG. However, C4C is less effective by the oral route because it only produces a maximum inhibition of about 35% even at the high dose of 100 mg/kg, whereas KP136 shows an overt inhibitory effect of about 66% at the oral dose of 2 mg/kg. On the other hand, KP136 (1 mg/kg, i.v.) also remarkably inhibits 5-h homologous PCA, having an activity similar to that of C4C.
KP136
上下游产品信息
上游原料
下游产品
76239-32-2, KP136 相关搜索:
- 化合物 T15666
- 76239-32-2
- KP-136,KP136
- 2H-1-Benzopyran-2-one, 8-(hexyloxy)-3-(2H-tetrazol-5-yl)-
- 8-(Hexyloxy)-3-(1H-tetrazol-5-yl)coumarin
- 8-(Hexyloxy)-3-(1H-tetrazol-5-yl)-2H-1-benzopyran-2-one
- KP 136
- AL-136