108852-42-2
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- CAS号:
- 108852-42-2
- 英文名:
- diperdipine
- 英文别名:
- YS-201;diperdipine;YS201,YS 201;3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-ethyl 5-[2-(1-piperidinyl)ethyl] ester
- 中文名:
- 108852-42-2
- 中文别名:
- 化合物 T17277
- CBNumber:
- CB41354270
- 分子式:
- C24H31N3O6
- 分子量:
- 457.52
- MOL File:
- 108852-42-2.mol
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108852-42-2化学性质
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沸点:
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593.9±50.0 °C(Predicted)
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密度:
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1?+-.0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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酸度系数(pKa):
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8.29±0.10(Predicted)
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108852-42-2性质、用途与生产工艺
YS-201是二氢吡啶类钙通道 (calcium channel) 拮抗剂,有潜力用于心绞痛和高血压的研究。
YS-201 (Diperdipine) markedly reduces systemic vascular resistance and improves stroke index and left ventricular ejection fraction. Mean pulmonary artery and wedge pressures are slightly increased as a possible consequence of enhanced venous return, whereas right atrial and left ventricular end-diastolic pressures are not significantly changed. Nevertheless, an increase in preload is clearly indicated by an augmented left ventricular end-diastolic volume index after administration of diperdipine. After intravenous and oral doses, absolute bioavailability is calculated to be 18.7%. Biliaryexcretion accounts for about 0.1% of the total clearance of diperdipine and does not contribute to the overall elimination of the drug. After intraportal administration, the bioavailable fraction of diperdipine is increasing up to 44.3% suggesting a prehepatic site of loss of the drug. The single application of diperdipine to mice and rats by gavage causes intolerance reactions starting at the lowest tested dose level of 200 mg/kg b.w. p.o. (mice) and at 250 mg/kg b.w. p.o. (rats). In the rat, toxic effects occur from 15 mg diperdipine/kg b.w./day p.o. onwards.
108852-42-2
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下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/04/30 | HY-U00137 | 108852-42-2 YS-201 | 108852-42-2 | 1mg | 2000元 |
2024/04/30 | HY-U00137 | 108852-42-2 YS-201 | 108852-42-2 | 5mg | 4000元 |
108852-42-2, 108852-42-2 相关搜索:
- 化合物 T17277
- 108852-42-2
- YS201,YS 201
- 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-ethyl 5-[2-(1-piperidinyl)ethyl] ester
- YS-201
- diperdipine