安三烯菌素B
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- CAS号:
- 82189-04-6
- 英文名:
- mycotrienin II
- 英文别名:
- mycotrienin II;T 23II, Mycotrienin II, T 23II;20,23-Didehydro-20,23-dideoxo-20,23-dihydroxyansatrienol A 11-[(R)-2-(cyclohexylcarbonylamino)propanoate];D-Alanine, N-(cyclohexylcarbonyl)-, (5R,6E,8E,10E,13S,14R,15R,16Z)-15,22,24-trihydroxy-5-methoxy-14,16-dimethyl-3-oxo-2-azabicyclo[18.3.1]tetracosa-1(24),6,8,10,16,20,22-heptaen-13-yl ester
- 中文名:
- 安三烯菌素B
- 中文别名:
- 安莎三烯 B;安三烯菌素B
- CBNumber:
- CB41375521
- 分子式:
- C36H50N2O8
- 分子量:
- 638.79
- MOL File:
- 82189-04-6.mol
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安三烯菌素B化学性质
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储存条件:
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-20°C
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溶解度:
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Soluble in DMSO, DMF, Ethanol or Methanol
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形态:
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solid
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颜色:
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Pale-yellow
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稳定性:
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Stable for 1 year from date of purchase as supplied. Solutions in DMSO, DMF, ethanol, or methanol may be stored at -20°C for up to 3 months.
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安三烯菌素B性质、用途与生产工艺
Ansatrienin B (Mycotrienin II) 是从链霉菌中分离得到的一种抗生素 (antibiotic)。Ansatrienin B 对真菌和酵母有活性,但对细菌无活性。Ansatrienin B 具有抗肿瘤活性,可作为 ADC 毒素分子。
Ansatrienin B exhibits antimicrobial activities of
Penicillium chrysogenuin
1AM 7106,
Mucor pusillus
IAM 6122,
Rhizopus delemar
IAM 6015,
Saccharornyces cerevisiae
IFO 0304,
Candida utilus
IFO 0396 and
Candida krusei
IFO 0590 with MIC values of 12.5 μg/ml, 12.5 μg/ml, 12.5 μg/ml, 8.0 μg/ml, 4.0 μg/ml, 4.0 μg/ml, and 4.0 μg/ml, respectively.
Ansatrienin B inhibits the release of
45
calcium into the culture medium by fetal rat long bones with an apparent halfmaximal inhibition (IC
50
) value of 21 nM.Ansatrienin B inhibits the translationof the protein synthesis stage by specific inhibition of L-leucine incorporation (IC
50
=58 nM) in A549 cells). At the same time, it also inhibits TNF-α-induced expression of ICAM-1 with an IC
50
of 300 nM.
Ansatrienin B (intraperitoneal injection; once daily; 6 days) is against P-388 -injected mouse tumor growth. The LD
50
value in mice of MTN-II is 80 mg/kg in CDF1 male mice.
安三烯菌素B
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上游原料
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82189-04-6, 安三烯菌素B 相关搜索:
- 微生物代谢物
- 安莎三烯 B
- 安三烯菌素B
- 82189-04-6
- D-Alanine, N-(cyclohexylcarbonyl)-, (5R,6E,8E,10E,13S,14R,15R,16Z)-15,22,24-trihydroxy-5-methoxy-14,16-dimethyl-3-oxo-2-azabicyclo[18.3.1]tetracosa-1(24),6,8,10,16,20,22-heptaen-13-yl ester
- T 23II, Mycotrienin II, T 23II
- 20,23-Didehydro-20,23-dideoxo-20,23-dihydroxyansatrienol A 11-[(R)-2-(cyclohexylcarbonylamino)propanoate]
- mycotrienin II