hepsulfam
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- CAS号:
- 96892-57-8
- 英文名:
- hepsulfam
- 英文别名:
- hepsulfam;NSC-329680;NCI 329680;ZINC01574758;7-sulfamoyloxyheptyl sulfamate;Sulfamic acid, S,S'-1,7-heptanediyl ester;Bissulfamideoic acid 1,7-heptanediyl ester;Bis(amidosulfuric acid)1,7-heptanediyl ester
- 中文名:
- hepsulfam
- 中文别名:
- 化合物 T15472
- CBNumber:
- CB41378537
- 分子式:
- C7H18N2O6S2
- 分子量:
- 290.36
- MOL File:
- 96892-57-8.mol
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hepsulfam化学性质
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熔点:
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94-95 °C
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沸点:
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478.2±55.0 °C(Predicted)
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密度:
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1.407±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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酸度系数(pKa):
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9.10±0.70(Predicted)
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hepsulfam性质、用途与生产工艺
Hepsulfam (NCI 329680; ZINC01574758) 是抗癌试剂,具有优异的抗白血病活性,在不同肿瘤中的中位 IC50 值为0.91 μg/mL。
IC50: 0.91 μg/mL (Tumors)
At a concentration of 1.0 μg/mL, hepsulfam is active in eight of 37 tumors (22%) in the clonogenic assay. Hepsulfam demonstrates a clear
in vitro
toxicity to human bone marrow cells (CFU-GM) from healthy donors. Evaluation of equitoxic concentrations
in vitro
reveals a higher activity of hepsulfam, especially in non-small cell lung cancer. Hepsulfam is more toxic to L1210 leukemia cells than is busulfan, its structural homologue . Consistent with the difference in toxicity, hepsulfam induces DNA interstrand cross-links in L1210 mouse leukemia cells, whereas busulfan does not. Hepsulfam is more cytotoxic to two human leukemia cell lines (111-60 and K562) and to two human colon carcinoma cell lines (BE and HT-29) than is busulfan. As in 11210 cells, hepsulfam induces a higher level of DNA interstrand cross-links than busulfan. Hepsulfam is also more cytotoxic to the human leukemia cell lines when the concentrations are reduced 10-fold and the duration of drug exposure is increased to 12 h.
Hepsulfam demonstrates superior
in vivo
activity in a large cell lung cancer xenograft and a gastric carcinoma model. The preclinical activity of hepsulfam suggests a possible role of this compound in the treatment of solid human malignancies. However, the increased bone marrow toxicity of hepsulfam as compared with busulfan might be critical for further clinical application.
hepsulfam
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更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/01/25 | HY-U00095 | hepsulfam Hepsulfam | 96892-57-8 | 1mg | 720元 |
2024/01/25 | HY-U00095 | hepsulfam Hepsulfam | 96892-57-8 | 5mg | 1440元 |
96892-57-8, hepsulfam 相关搜索:
- C7H18N2O6S2
- 化合物 T15472
- 96892-57-8
- 7-sulfamoyloxyheptyl sulfamate
- NCI 329680
- ZINC01574758
- Sulfamic acid, S,S'-1,7-heptanediyl ester
- NSC-329680
- Bissulfamideoic acid 1,7-heptanediyl ester
- Bis(amidosulfuric acid)1,7-heptanediyl ester
- hepsulfam