盐酸法倔唑
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- CAS号:
- 102676-31-3
- 英文名:
- FADROZOLE HYDROCHLORIDE
- 英文别名:
- CS-356;D02451;Fadrazole;CGS-16949A;Fadrozole HCl;FADROZOLE HYDROCHLORIDE;Fadrozole HCl (CGS-16949A);Fadrozole hydrochloride (usan);FADROZOLE (HYDROCHLORIDE);CGS 16949A;4-(5,6,7,8-TETRAHYDROIMIDAZO[1,5-A]PYRIDIN-5-YL)BENZONITRILE(WXC09920)
- 中文名:
- 盐酸法倔唑
- 中文别名:
- 盐酸法卓唑;法倔唑盐酸盐;4-(5,6,7,8-四氢咪唑并[1,5-A]吡啶-5-基)苯腈盐酸盐
- CBNumber:
- CB41504066
- 分子式:
- C14H13N3.ClH
- 分子量:
- 259.739
- MOL File:
- 102676-31-3.mol
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盐酸法倔唑化学性质
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熔点:
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231-233℃
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储存条件:
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room temp
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溶解度:
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DMSO: >20mg/mL
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形态:
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powder
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颜色:
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Pale Beige to Pale Yellow
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稳定性:
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Hygroscopic
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盐酸法倔唑性质、用途与生产工艺
Fadrozole hydrochloride (CGS 16949A) 是一种有效，选择性和非甾体类的 aromatase 抑制剂，其 IC50 值为 6.4 nM。
Fadrozole hydrochloride is a potent, selective and nonsteroidal inhibitor of aromatase with an IC
50
of 6.4 nM. In hamster ovarian slices, Fadrozole hydrochloride inhibits the production of estrogen with an IC
50
of 0.03 μM. The production of progesterone is inhibited with an IC
50
of 120 μM. Synthesis of other cytochrome P-450 dependent steroids can be suppressed to various degrees with higher doses of Fadrozole hydrochloride.
Fadrozole hydrochloride is able to inhibit the aromatase-mediated uterine hypertrophy in immature female rats with an ED
50
of 0.03 mg/kg when given orally. In the same model, aminoglutethimide elicits the same effect with an ED
50
of 30 mg/kg when given orally. Fadrozole hydrochloride prevents the development of both benign and malignant spontaneus mammary neoplasns in female Sprague-Dawley rats. It also slows the spontaneous development of ptuitary pars distalis adenomas in female rats, and reduces the incidence of spontaneous hepatocellular tumours in male and female rats. Administration of Fadrozole hydrochloride in male and female mice accompanies with a 70% reduction in parasite burden. This protective effect is associated in male mice with a recovery of the specific cellular immune response. Interleukin-6 (IL-6) serum levels, and its production by splenocytes, is augmented by 80%, together with a 10-fold increase in its expression in testes of infected male mice. Fadrozole hydrochloride treatment returns these levels to baseline values.
盐酸法倔唑
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-14247 | 盐酸法倔唑
Fadrozole hydrochloride | 102676-31-3 | 5mg | 660元 |
| 2024/01/25 | HY-14247 | 盐酸法倔唑
Fadrozole hydrochloride | 102676-31-3 | 10mM * 1mLin DMSO | 726元 |
102676-31-3, 盐酸法倔唑 相关搜索:
- 高端化学
- 化学连接
- C14H13N3ClH
- 盐酸法卓唑
- 4-(5,6,7,8-四氢咪唑并[1,5-A]吡啶-5-基)苯腈盐酸盐
- 法倔唑盐酸盐
- 102676-31-3
- P-450,(Rac)-FAD286,Aromatase,spontaneous tumour,Fadrozole hydrochloride,Fadrozole,Inhibitor,Estrogen,progesterone,inhibit
- Fadrozole HCl (CGS-16949A)
- Benzonitrile, 4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)-, hydrochloride (1:1)
- FADROZOLE (HYDROCHLORIDE);CGS 16949A
- CS-356
- +-5-(p-cyanophenyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridine hydrochloride
- Fadrozole HCl
- 4-(5,6,7,8-TETRAHYDROIMIDAZO[1,5-A]PYRIDIN-5-YL)BENZONITRILE(WXC09920)
- 4-(5,6,7,8-Tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile hydrochloride
- Fadrozole hydrochloride (usan)
- D02451
- Fadrazole
- CGS-16949A
- FADROZOLE HYDROCHLORIDE