多佐胺
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- CAS号:
- 120279-96-1
- 英文名:
- Dorzolamide
- 英文别名:
- C06969;DORZOLAMIDE;4S,6S-Dorzolamide;Dorzolamide-d5 Maleate;Dorzolamide >=98% (HPLC);Dorzalamide hydrochloride;DORZOLAMIDE(SUBJECTTOPATENTFREE);Dorzolamide Impurity A Hydrochloride;(4S,6S)-4-(ethylamino)-5,6-dihydro-6-methyl-7,;7-dioxide-4H-Thieno[2,3-b]thiopyran-2-sulfonamide/ Dorzolamide
- 中文名:
- 多佐胺
- 中文别名:
- 蒲勒酮;多佐胺;杜塞酰胺;多佐胺杂质;多佐胺盐酸盐;多佐胺-2-6;多佐胺/杜塞酰胺;多佐胺-D5马来酸盐;(4S,6S)-4-(乙氨基)-5,6-二氢-6-甲基-4H-噻吩并[2,3-B]噻喃-2-磺酰胺7,7-二氧化物;(2R,4R)-2-乙基氨基-4-甲基-5,5-二氧代-5,7-二硫杂双环[4.3.0]壬-8,10-二烯-8-磺酰胺
- CBNumber:
- CB4174657
- 分子式:
- C10H16N2O4S3
- 分子量:
- 324.44
- MOL File:
- 120279-96-1.mol
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多佐胺化学性质
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沸点:
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575.8±60.0 °C(Predicted)
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密度:
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1.53±0.1 g/cm3(Predicted)
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储存条件:
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room temp
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溶解度:
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DMSO: soluble5mg/mL (clear solution, warmed)
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酸度系数(pKa):
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pKa 6.35 (Uncertain);8.50 (Uncertain)
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形态:
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powder
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颜色:
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white to beige
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旋光性 (optical activity):
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[α]/D -25 to -35°, c = 1 in methanol
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CAS 数据库:
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120279-96-1(CAS DataBase Reference)
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多佐胺性质、用途与生产工艺
Dorzolamide (L671152) 是有效的碳酸酐酶 carbonic anhydrase II 的抑制剂,其对红细胞 CA-II 和 CA-I 的 IC50 值分别为 0.18 nM 和 600 nM。
Component A, caused by an inward flux of CO2 and its subsequent hydration by CA-II, is blocked by Dorzolamide in a dose-dependent manner with an 50% inhibitory concentration IC
50
of 2.4 μM (95% confidence interval: 0.5-10.85 μM).
Dorzolamide (3, 10, or 30 mg/kg/day, ip) synergized mitomycin C exhibits anti-tumor activity in EAC solid tumor models. Dorzolamide produces a dose-dependent decrease in the calculated ratio (relative value of 57.3±1, 25.5±1.8, and 24.3± 0.7 %, respectively).
Animal Model:
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Female Swiss albino mice (EAC solid tumor).
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Dosage:
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3, 10, or 30 mg/kg/day (synergized mitomycin C).
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Administration:
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IP, daily for 3 weeks.
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Result:
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Upregulated TXNIP and p53 while downregulated bcl-2.
Effective in retarding the growth of EAC in mice.
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多佐胺
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120279-96-1, 多佐胺 相关搜索:
- C10H16N2O4S3
- 12079-96-1
- (4S,6S)-4-(乙氨基)-5,6-二氢-6-甲基-4H-噻吩并[2,3-B]噻喃-2-磺酰胺7,7-二氧化物
- 多佐胺-D5马来酸盐
- 蒲勒酮
- 多佐胺盐酸盐
- 多佐胺
- 杜塞酰胺
- 多佐胺-2-6
- (2R,4R)-2-乙基氨基-4-甲基-5,5-二氧代-5,7-二硫杂双环[4.3.0]壬-8,10-二烯-8-磺酰胺
- 多佐胺/杜塞酰胺
- 多佐胺杂质
- 120279-96-1
- Dorzolamide Impurity A Hydrochloride
- DorzolamideQ: What is
Dorzolamide Q: What is the CAS Number of
Dorzolamide Q: What is the storage condition of
Dorzolamide Q: What are the applications of
Dorzolamide
- Dorzolamide-d5 Maleate
- Dorzolamide >=98% (HPLC)
- (4S,6S)-4-(ethylamino)-6-methyl-7,7-dioxo-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide
- (2S,4S)-4-(ethylaMino)-2-Methyl-1,1-dioxo-2H,3H,4H-1$l^{6},7-thieno[2,3-b][1$l^{6}]thiopyran-6-sulfonaMide
- C06969
- (2r,4r)-2-ethylamino-4-methyl-5,5-dioxo-5,7-dithiabicyclo[4.3.0]nona-8,10-diene-8-sulfonamide
- 7-dioxide-4H-Thieno[2,3-b]thiopyran-2-sulfonamide/ Dorzolamide
- Dorzalamide hydrochloride
- (4S,6S)-4-(ethylamino)-5,6-dihydro-6-methyl-7,
- (4S,6S)-4H-Thieno[2,3-b]thiopyran-2-sulfonamide, 4-(ethylamino)-5,6-dihydro-6-methyl-, 7,7-dioxide
- 4S,6S-Dorzolamide
- 4H-Thieno[2,3-b]thiopyran-2-sulfonamide, 4-(ethylamino)-5,6-dihydro-6-methyl-, 7,7-dioxide, (4S-trans)-
- 4H-Thieno[2,3-b]thiopyran-2-sulfonamide, 4-(ethylamino)-5,6-dihydro-6-methyl-, 7,7-dioxide, (4S,6S)-
- DORZOLAMIDE(SUBJECTTOPATENTFREE)
- DORZOLAMIDE