STEM-CELL FACTOR/C-KIT 抑制剂
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- CAS号:
- 945526-43-2
- 英文名:
- [4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide, Benzenesulfonamide, 4-(1,1-dimethylethyl)-N-[4-(1H-imidazol-1-yl)phenyl]-
- 英文别名:
- ISCK03;ISCK 03; ISCK-03;C-KIT INHIBITOR II;Stem-Cell Factor/c-Kit Inhibitor;SteM-Cell Factor/c-Kit Inhibitor, ISCK03;T-Butylphenyl Imidazolylphenyl Sulfonamide;[4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide;4-tert-butyl-N-(4-imidazol-1-ylphenyl)benzenesulfonamide;inhibit,SCFR,c-Kit,ISCK-03,CD117,Inhibitor,ISCK03,ISCK 03;N-(4-(1H-Imidazol-1-yl)phenyl)-4-(tert-butyl)benzenesulfonamide
- 中文名:
- STEM-CELL FACTOR/C-KIT 抑制剂
- 中文别名:
- 化合物ISCK03;ISCK03,SCF / C-KIT抑制剂;STEM-CELL FACTOR/C-KIT 抑制剂 ;4-(1,1-二甲基乙基)-N-(4-(1H-咪唑-1-基)苯基)苯磺酰胺
- CBNumber:
- CB42098935
- 分子式:
- C19H21N3O2S
- 分子量:
- 355.45
- MOL File:
- 945526-43-2.mol
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STEM-CELL FACTOR/C-KIT 抑制剂 化学性质
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储存条件:
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Sealed in dry,2-8°C
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溶解度:
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Soluble in ethanol or DMSO
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形态:
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solid
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颜色:
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yellow
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敏感性:
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Light Sensitive
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InChIKey:
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XQABBHBFHWHMKF-UHFFFAOYSA-N
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STEM-CELL FACTOR/C-KIT 抑制剂 性质、用途与生产工艺
ISCK03 (N-(4-imidazol-1-yl phenyl)sulfonamide)是stem-cell factor (SCF)/c-kit信号通路的细胞渗透性抑制剂。ISCK03抑制SCF介导的c-c-kit磷酸化和下游ERK磷酸化。
| Target | Value |
SCF
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c-Kit
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Pretreatment of 501mel cells with ISCK03 inhibits SCF-induced c-kit phosphorylation dose dependently. ISCK03 also inhibits p44/42 ERK mitogen-activated protein kinase (MAPK) phosphorylation, which is known to be involved in SCF/c-kit downstream signaling. However ISCK03 does not inhibit hepatocyte growth factor (HGF)-induced phosphorylation of p44/42 ERK proteins. ISCK03, a tyrosine kinase inhibitor specific to KIT, prevents survival of CCDC26-KD cells under low-serum conditions. All treated cells exhibits sensitivity to ISCK03 in a dose-dependent manner. After ISCK03 treatment, the survival of KD cells is suppressed to the same level as that of non-KD cells. Conversely, ISCK03 treatment has limited effects on the growth of control K562 and KD clone 3–4 cells under high-serum concentration conditions.
Oral administration of ISCK03 induces the dose-dependent depigmentation of newly regrown hair, and this is reversed with cessation of ISCK03 treatment. The topical application of ISCK03 promotes the depigmentation of UV-induced hyperpigmented spots. Fontana-Masson staining analysis shows epidermal melanin is diminished in spots treated with ISCK03.
STEM-CELL FACTOR/C-KIT 抑制剂
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-101443 | STEM-CELL FACTOR/C-KIT 抑制剂
ISCK03 | 945526-43-2 | 5mg | 600元 |
| 2024/04/30 | HY-101443 | STEM-CELL FACTOR/C-KIT 抑制剂
ISCK03 | 945526-43-2 | 10mM * 1mLin DMSO | 660元 |
STEM-CELL FACTOR/C-KIT 抑制剂
生产厂家
945526-43-2, STEM-CELL FACTOR/C-KIT 抑制剂 相关搜索:
- API
- 药靶配体
- ISCK03,SCF / C-KIT抑制剂
- 4-(1,1-二甲基乙基)-N-(4-(1H-咪唑-1-基)苯基)苯磺酰胺
- 化合物ISCK03
- STEM-CELL FACTOR/C-KIT 抑制剂
- 945526-43-2
- N-(4-(1H-Imidazol-1-yl)phenyl)-4-(tert-butyl)benzenesulfonamide
- T-Butylphenyl Imidazolylphenyl Sulfonamide
- inhibit,SCFR,c-Kit,ISCK-03,CD117,Inhibitor,ISCK03,ISCK 03
- Stem-Cell Factor/c-Kit Inhibitor
- C-KIT INHIBITOR II
- Stem-Cell Factor/c-Kit Inhibitor, ISCK03 - CAS 945526-43-2 - Calbiochem
- 4-tert-butyl-N-(4-imidazol-1-ylphenyl)benzenesulfonamide
- ISCK 03; ISCK-03
- Benzenesulfonamide,4-(1,1-dimethylethyl)-N-[4-(1H-imidazol-1-yl)phenyl]
- [4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide
- SteM-Cell Factor/c-Kit Inhibitor, ISCK03
- ISCK03
- [4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide, Benzenesulfonamide, 4-(1,1-dimethylethyl)-N-[4-(1H-imidazol-1-yl)phenyl]-