化合物 T16947
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- CAS号:
- 251356-45-3
- 英文名:
- SU 16f
- 英文别名:
- SU 16f;PDGFR Tyrosine Kinase Inhibitor VII - CAS 251356-45-3 - Calbiochem;(Z)-3-(2,4-Dimethyl-5-((2-oxo-6-phenylindolin-3-ylidene)methyl)-1H-pyrrol-3-yl)propanoic acid;5-[1,2-Dihydro-2-oxo-6-phenyl-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-propanoicacid;1H-Pyrrole-3-propanoic acid, 5-[(1,2-dihydro-2-oxo-6-phenyl-3H-indol-3-ylidene)methyl]-2,4-dimethyl-
- 中文名:
- 化合物 T16947
- 中文别名:
- 化合物SU16F;化合物 T16947;SU 16F,PDGFRΒ抑制剂
- CBNumber:
- CB42501833
- 分子式:
- C24H22N2O3
- 分子量:
- 386.44
- MOL File:
- 251356-45-3.mol
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化合物 T16947化学性质
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沸点:
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661.7±55.0 °C(Predicted)
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密度:
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1.292±0.06 g/cm3(Predicted)
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储存条件:
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Store at RT
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溶解度:
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Soluble to 100 mM in DMSO
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形态:
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Dark orange solid
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酸度系数(pKa):
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4?+-.0.10(Predicted)
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化合物 T16947性质、用途与生产工艺
SU16f 是有效的，选择性 PDGFRβ 抑制剂，对 PDGFRβ，PDGFR1，PDGFR2 的 IC50 分别为 10 nM，140 nM，2.29 μM。SU16f 抑制 PDGFRβ 受体从而可以阻断胃癌来源的间充质干细胞 (GC-MSC) 条件培养基在胃癌细胞增殖和迁移中的促进作用。
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PDGFRβ
10 nM (IC
50
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PDGFR2
140 nM (IC
50
)
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PDGFR1
2.29 μM (IC
50
)
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SU16f (20 μM; for 8 hours) pretreatment inhibits the promoting role of GC-MSC-CM in SGC-7901 cell proliferation.
SU16f (20 μM; for 8 hours) significantly abolishes PDGFRβ activation in SGC-7901 by GC-MSC-CM. SU16f pretreatment results in the upregulation of E-cadherin and downregulation of N-cadherin, Vimentin, and α-SMA. SU16f pretreatment leads to downregulation of p-AKT, Bcl-xl, and Bcl-2 levels and upregulation of Bax expression in SGC-7901 cells by GC-MSC-CM .
Cell Proliferation Assay
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Cell Line:
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SGC-7901 cells in GC-MSC/SGC-7901 co-culture system
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Concentration:
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20 μM
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Incubation Time:
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8 hours
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Result:
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Inhibited the promoting role of GC-MSC-CM in SGC-7901 cell proliferation.
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Western Blot Analysis
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Cell Line:
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SGC-7901 cells
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Concentration:
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20 μM
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Incubation Time:
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8 hours
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Result:
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Significantly abolished PDGFRβ activation in SGC-7901 by GC-MSC-CM, and resulted in the upregulation of E-cadherin and downregulation of N-cadherin, Vimentin, and α-SMA.
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化合物 T16947
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/04/30 | HY-108628 | 化合物 T16947
SU16f | 251356-45-3 | 1 mg | 480元 |
| 2024/04/30 | HY-108628 | 化合物 T16947
SU16f | 251356-45-3 | 5mg | 980元 |
251356-45-3, 化合物 T16947 相关搜索:
- Angiogenesis and Metastasis
- 酶
- SU 16F,PDGFRΒ抑制剂
- 化合物SU16F
- 化合物 T16947
- 251356-45-3
- 1H-Pyrrole-3-propanoic acid, 5-[(1,2-dihydro-2-oxo-6-phenyl-3H-indol-3-ylidene)methyl]-2,4-dimethyl-
- PDGFR Tyrosine Kinase Inhibitor VII - CAS 251356-45-3 - Calbiochem
- SU 16f
- (Z)-3-(2,4-Dimethyl-5-((2-oxo-6-phenylindolin-3-ylidene)methyl)-1H-pyrrol-3-yl)propanoic acid
- 5-[1,2-Dihydro-2-oxo-6-phenyl-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-propanoicacid