VEGFR2
12 nM (IC 50 )
PDGFR
2 nM (IC 50 )
mTOR
10 nM (IC 50 )
DNK-PK
60 nM (IC 50 )
Src
14 nM (IC 50 )
Oral administration of PP121 remarkably inhibits Eca-109 xenograft growth. Mice body weights are not significantly affected by PP121 or the vehicle treatment. PP121 oral administration dramatically inhibits activations of Akt-mTOR and NFkB in xenograft tumors. p-Akt Ser 473 and p-IKKa/b are both inhibited by PP121 administration.