Pep2m, myristoylated
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- CAS号:
- 1423381-07-0
- 英文名:
- Pep2m, myristoylated
- 英文别名:
- Pep2m, myristoylated
- 中文名:
- Pep2m, myristoylated
- 中文别名:
- MYRQ-11;MYR-LYS-ARG-MET-LYS-VAL-ALA-LYS-ASN-ALA-GLN-OH
- CBNumber:
- CB42518729
- 分子式:
- C63H118N18O14S
- 分子量:
- 1383.81
- MOL File:
- 1423381-07-0.mol
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Pep2m, myristoylated化学性质
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密度:
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1.32±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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酸度系数(pKa):
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3.25±0.10(Predicted)
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水溶解性:
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Soluble to 1 mg/ml in sterile water
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Pep2m, myristoylated性质、用途与生产工艺
Pep2m, myristoylated (Myr-Pep2m) 是一种细胞通透性肽。Pep2m, myristoylated (Myr-Pep2m) 能破坏蛋白激酶 ζ (PKMζ) 下游靶点 NSF/GluR2 相互作用。PKMζ 具有自主活性的 PKC 同工酶。
Pep2m, myristoylated (10 μM) blocks PKMζ-mediated AMPA receptor (AMPAR) potentiation.
Pep2m, myristoylated does not block the increase of PKMζ in the hippocampal slices during long-term potentiation (LTP) maintenance, indicating that blocking NSF/GluR2 interactions do not prevent the induction of PKMζ synthesis.
Pep2m, myristoylated blocks NSF/GluR2-mediated AMPAR trafficking, and reverses persistent potentiation at both the strongly stimulates synapses and the weakly stimulats synapses that underwent synaptic tagging and capture.
Pep2m, myristoylated (10 µg) results in an increase in paw withdrawal thresholds (PWTs) on nociceptive responses in the formalin test.
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Animal Model:
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Female and male Long-Evans hooded rats (8 weeks)
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Dosage:
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10 µg (in 20 µL)
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Administration:
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Intrathecal injection
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Result:
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Resulted in an increase in PWTs, in both male and female rats at various time points tested.
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Pep2m, myristoylated
上下游产品信息
上游原料
下游产品
Pep2m, myristoylated
生产厂家
1423381-07-0, Pep2m, myristoylated 相关搜索:
- 目录多肽
- C63H118N18O14S
- MYRQ-11
- MYR-LYS-ARG-MET-LYS-VAL-ALA-LYS-ASN-ALA-GLN-OH
- 1423381-07-0
- Pep2m, myristoylated